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    Fam219b family with sequence similarity 219, member B [ Mus musculus (house mouse) ]

    Gene ID: 78323, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Fam219bprovided by MGI
    Official Full Name
    family with sequence similarity 219, member Bprovided by MGI
    Primary source
    MGI:MGI:1925573
    See related
    Ensembl:ENSMUSG00000032305 AllianceGenome:MGI:1925573
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310046O06Rik
    Summary
    Orthologous to human FAM219B (family with sequence similarity 219 member B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.8), adrenal adult (RPKM 4.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 B; 9 31.05 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57443648..57450471)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57536685..57543188)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24239 Neighboring gene ribonuclease P/MRP 25 subunit Neighboring gene STARR-positive B cell enhancer ABC_E11408 Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene mannose phosphate isomerase Neighboring gene STARR-positive B cell enhancer ABC_E3834 Neighboring gene STARR-positive B cell enhancer ABC_E3835 Neighboring gene secretory carrier membrane protein 2 Neighboring gene unc-51-like kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM219B
    Names
    uncharacterized protein C15orf17 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166364.1 → NP_001159836.1  protein FAM219B isoform 1

      See identical proteins and their annotated locations for NP_001159836.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK028365, AV370547, BC112403
      Consensus CDS
      CCDS52807.1
      UniProtKB/Swiss-Prot
      Q14DQ1, Q8BSZ6
      Related
      ENSMUSP00000109838.3, ENSMUST00000114200.10
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 197
      FAM219A; Protein family FAM219A

    2. NM_175273.4 → NP_780482.1  protein FAM219B isoform 2

      See identical proteins and their annotated locations for NP_780482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a frame-shifting exon in the 3' coding region, compared to variant 1. This difference results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK028365, AV370547, BC112403
      Consensus CDS
      CCDS52808.1
      UniProtKB/Swiss-Prot
      Q14DQ1
      Related
      ENSMUSP00000091353.5, ENSMUST00000093833.6
      Conserved Domains (1) summary
      pfam15260
      Location:72 → 128
      FAM219A; Protein family FAM219A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57443648..57450471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511558.5 → XP_006511621.3  protein FAM219B isoform X1

      Conserved Domains (1) summary
      pfam15260
      Location:120 → 224
      FAM219A; Protein family FAM219A

    2. XM_006511559.5 → XP_006511622.3  protein FAM219B isoform X2

      Conserved Domains (1) summary
      pfam15260
      Location:120 → 175
      FAM219A; Protein family FAM219A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14DQ1.1 GenPept UniProtKB/Swiss-Prot:Q14DQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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