OR51E2 olfactory receptor family 51 subfamily E member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: OR51E2provided by HGNC
Official Full Name: olfactory receptor family 51 subfamily E member 2provided by HGNC
Primary source: HGNC:HGNC:15195
See related: Ensembl:ENSG00000167332 MIM:611268; AllianceGenome:HGNC:15195
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PSGR; HPRAJ; OR52A2; OR51E3P
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 29.8) and placenta (RPKM 2.3) See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (4680171..4697853, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (4745678..4763359, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (4701401..4719083, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis of odorant recognition by a human odorant receptor.
Title: Structural basis of odorant recognition by a human odorant receptor.
Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line.
Title: Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line.
Coexpression of peripheral olfactory receptors with SARSCoV2 infection mediators: Potential implications beyond loss of smell as a COVID19 symptom.
Title: Co‑expression of peripheral olfactory receptors with SARS‑CoV‑2 infection mediators: Potential implications beyond loss of smell as a COVID‑19 symptom.
Exosome carrying PSGR promotes stemness and epithelial-mesenchymal transition of low aggressive prostate cancer cells.
Title: Exosome carrying PSGR promotes stemness and epithelial-mesenchymal transition of low aggressive prostate cancer cells.
Olfactory receptor OR51E2, also known as a Prostate Specific G-Protein Receptor, is highly expressed in prostate cancer. We identified 24 agonists and 1 antagonist for this receptor. We detected that agonist 19-hydroxyandrostenedione, a product of the aromatase reaction, is endogenously produced upon receptor activation and contributes to neuroendocrine transdifferentiation of prostate cancer LNCaP cells.
Title: A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor.
Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells. In a heterologous expression system, OR51E2 trafficked readily to the cell surface and showed ligand selectivity and sensitivity to the short chain fatty acids (SCFAs) acetate and propionate.
Title: Defining an olfactory receptor function in airway smooth muscle cells.
OR51E2 is involved in the regulation of cell proliferation and migration in human primary melanoma and melanoma metastasis
Title: Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis.
Two genes, OR51E2 and SIM2, and two miRNAs, miR-200c and miR-200b, showed significant association with prostate cancer.
Title: Circulating mRNAs and miRNAs as candidate markers for the diagnosis and prognosis of prostate cancer.
Plasma membrane preparations showed that OR51E2 protein is present at the melanocyte cell surface.
Title: Functional Characterization of the Odorant Receptor 51E2 in Human Melanocytes.
PSGR overexpression synergizes with loss of PTEN to accelerate prostate cancer development, and present a novel bigenic mouse model that mimics the human condition
Title: Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156606P1 (e-PCR)
- UniSTS:271408

G60018 (e-PCR)
- UniSTS:137284

RH48171 (e-PCR)
- UniSTS:83352

D11S2420 (e-PCR)
- UniSTS:46753

SHGC-155536 (e-PCR)
- UniSTS:182465

SHGC-155730 (e-PCR)
- UniSTS:182467

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear steroid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables olfactory receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to fatty acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of chemical stimulus involved in sensory perception of smell	IEA Inferred from Electronic Annotation more info
involved_in melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of renin secretion into blood stream	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid hormone mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: olfactory receptor 51E2

Names: olfactory receptor OR11-16; olfactory receptor, family 51, subfamily E, member 3 pseudogene; olfactory receptor, family 52, subfamily A, member 2; prostate-specific G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030774.4 → NP_110401.1 olfactory receptor 51E2

See identical proteins and their annotated locations for NP_110401.1

Status: VALIDATED

Source sequence(s)

AC090719, AK314051

Consensus CDS

CCDS7751.1

UniProtKB/Swiss-Prot

B2RA63, Q6IF94, Q9H255

UniProtKB/TrEMBL

A0A126GVK0

Related

ENSP00000380153.3, ENST00000396950.4

Conserved Domains (1) summary

cd15222
Location:24 → 298

7tmA_OR51-like; olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors