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    FBXL18 F-box and leucine rich repeat protein 18 [ Homo sapiens (human) ]

    Gene ID: 80028, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FBXL18provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 18provided by HGNC
    Primary source
    HGNC:HGNC:21874
    See related
    Ensembl:ENSG00000155034 MIM:609084; AllianceGenome:HGNC:21874
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbl18
    Summary
    The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
    Expression
    Ubiquitous expression in brain (RPKM 2.3), fat (RPKM 1.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (5454425..5513809, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (5571979..5631328, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (5494056..5553440, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 29 member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5350589-5351090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5351091-5351590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362189-5362722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5362723-5363256 Neighboring gene trinucleotide repeat containing 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5387551-5388392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5390077-5390917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5395754-5396256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5421456-5422020 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5422021-5422584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5441055-5441556 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5443987-5444488 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447331-5447920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5447921-5448510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5458249-5458998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5467243-5467992 Neighboring gene long intergenic non-protein coding RNA 2983 Neighboring gene long intergenic non-protein coding RNA 3073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5485342-5486174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5491262-5491967 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5495336-5495836 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5526631-5527352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:5528075-5528796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5549867-5550805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:5552897-5553483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5553484-5554070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5554071-5554656 Neighboring gene microRNA 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25585 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25586 Neighboring gene uncharacterized LOC221946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567118-5567988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5567989-5568858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:5568859-5569728 Neighboring gene actin beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt. Zhang J, et al. FEBS Lett, 2017 Jan. PMID 27926990
    2. Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity. Ding X, et al. Neurobiol Dis, 2017 Feb. PMID 27890708, Free PMC Article
    3. F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Liu Y, et al. Cell Death Dis, 2015 Feb 5. PMID 25654763, Free PMC Article
    4. SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Liu J, et al. Oncotarget, 2014 Feb 28. PMID 24657926, Free PMC Article
    5. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. Brandler WM, et al. PLoS Genet, 2013. PMID 24068947, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study showed that LRRK2 phosphorylation is required for LRRK2 to bind to Fbxl18, and that this interaction is important for regulating the amount of LRRK2 via ubiquitination of LRRK2 by the SCFFbxl18 ubiquitin ligase and subsequent proteasomal degradation of LRRK2. We also show that LRRK2 can induce caspase 8 mediated cell death and that the degradation of LRRK2 mediated by Fbxl18 can prevent LRRK2-mediated toxicity.
      Title: Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.
    2. FBXL18 plays an oncogenic role through promoting lysine 63-linked ubiquitination of Akt in glioma.
      Title: The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt.
    3. Fbxl18 regulates apoptosis by mediating ubiquitin-dependent proteasomal degradation of the pro-apoptotic protein Fbxl7 that may impact cellular processes involved in cell cycle progression.
      Title: F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10776, FLJ11467, FLJ26934, FLJ38075, FLJ41541

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321213.2 → NP_001308142.1  F-box/LRR-repeat protein 18 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
      Conserved Domains (3) summary
      sd00034
      Location:345 → 384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:33 → 75
      F-box-like; F-box-like
      pfam13900
      Location:763 → 779
      GVQW; Putative domain of unknown function

    2. NM_001363441.2 → NP_001350370.1  F-box/LRR-repeat protein 18 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      Related
      ENSP00000415064.1, ENST00000415009.5
      Conserved Domains (2) summary
      sd00034
      Location:345 → 384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:33 → 68
      F-box-like; F-box-like

    3. NM_001363442.2 → NP_001350371.1  F-box/LRR-repeat protein 18 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3
      Conserved Domains (2) summary
      sd00034
      Location:345 → 384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:33 → 68
      F-box-like; F-box-like

    4. NM_001367780.1 → NP_001354709.1  F-box/LRR-repeat protein 18 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform 5.
      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3

    5. NM_001367781.1 → NP_001354710.1  F-box/LRR-repeat protein 18 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform 5.
      Source sequence(s)
      AC006483, AC092171
      UniProtKB/TrEMBL
      A0A994ENR3

    6. NM_024963.6 → NP_079239.3  F-box/LRR-repeat protein 18 isoform 2

      See identical proteins and their annotated locations for NP_079239.3

      Status: REVIEWED

      Source sequence(s)
      AA878073, AC006483, AC092171, AK294949, BC013435, DC307306
      Consensus CDS
      CCDS43546.1
      UniProtKB/Swiss-Prot
      A0A024R857, B3KTC9, B4DH63, H0Y6I6, Q96ME1, Q9BR90, Q9BTC7, Q9HAK7
      Related
      ENSP00000371805.3, ENST00000382368.8
      Conserved Domains (2) summary
      sd00034
      Location:345 → 384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:33 → 75
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      5454425..5513809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      5571979..5631328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96ME1.3 GenPept UniProtKB/Swiss-Prot:Q96ME1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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