Rbsn rabenosyn, RAB effector [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbsnprovided by MGI
Official Full Name: rabenosyn, RAB effectorprovided by MGI
Primary source: MGI:MGI:1925537
See related: Ensembl:ENSMUSG00000014550 AllianceGenome:MGI:1925537
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zfyve20; 5330426D11Rik
Summary: Enables small GTPase binding activity. Predicted to be involved in Golgi to lysosome transport; early endosome to Golgi transport; and regulation of Golgi organization. Predicted to act upstream of or within protein transport. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in central nervous system; genitourinary system; and retina outer nuclear layer. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 6.2), cerebellum adult (RPKM 6.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 41.03 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (92163693..92191874, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (92186712..92214894, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rabenosyn-5

Names: FYVE finger-containing Rab5 effector protein rabenosyn-5; RAB effector RBSN; zinc finger FYVE domain-containing protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030081.3 → NP_084357.2 rabenosyn-5

See identical proteins and their annotated locations for NP_084357.2

Status: VALIDATED

Source sequence(s)

BC049106, BY149674

Consensus CDS

CCDS20374.1

UniProtKB/Swiss-Prot

Q80Y56, Q8K0L6, Q9CTW0

Related

ENSMUSP00000014694.9, ENSMUST00000014694.11

Conserved Domains (3) summary

cd15716
Location:150 → 261

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:460 → 498

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:548 → 726

NPF; Rabosyn-5 repeating NPF sequence-motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

92163693..92191874 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506769.5 → XP_006506832.1 rabenosyn-5 isoform X2

Conserved Domains (3) summary

cd15716
Location:62 → 173

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:372 → 408

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:460 → 638

NPF; Rabosyn-5 repeating NPF sequence-motif
XM_036152400.1 → XP_036008293.1 rabenosyn-5 isoform X1

Conserved Domains (3) summary

cd15716
Location:120 → 231

FYVE_RBNS5; FYVE domain found in FYVE finger-containing Rab5 effector protein rabenosyn-5 (Rbsn-5) and similar proteins

pfam11464
Location:430 → 468

Rbsn; Rabenosyn Rab binding domain

pfam16601
Location:518 → 696

NPF; Rabosyn-5 repeating NPF sequence-motif