SGTA small glutamine rich tetratricopeptide repeat co-chaperone alpha [Homo sapiens (human)] - Gene

Summary

Official Symbol: SGTAprovided by HGNC
Official Full Name: small glutamine rich tetratricopeptide repeat co-chaperone alphaprovided by HGNC
Primary source: HGNC:HGNC:10819
See related: Ensembl:ENSG00000104969 MIM:603419; AllianceGenome:HGNC:10819
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGT; Vpu; SGT1; hSGT; alphaSGT
Summary: This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 22.5), brain (RPKM 21.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (2754715..2783273, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (2730001..2758560, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (2754713..2783271, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

USP5 enhances SGTA mediated protein quality control.
Title: USP5 enhances SGTA mediated protein quality control.
SGTA associates with intracellular aggregates in neurodegenerative diseases.
Title: SGTA associates with intracellular aggregates in neurodegenerative diseases.
SGTA associates with nascent membrane protein precursors.
Title: SGTA associates with nascent membrane protein precursors.
The SGTA is a co-chaperone that, in collaboration with the complex of BAG6, facilitates the biogenesis and quality control of hydrophobic proteins, protecting them from the aqueous cytosolic environment.
Title: The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease.
the results provide novel insights into the structural complexity of SGTA and provide a new basis for mechanistic studies of substrate binding and release at the C-terminal region.
Title: Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control.
evidence that the interaction can mediate the association of Rpn13 and SGTA in a cellular context.
Title: SGTA interacts with the proteasomal ubiquitin receptor Rpn13 via a carboxylate clamp mechanism.
Coimmunoprecipitation studies indicated that non-glycosylated tetherin is stabilized through the formation of a ternary SGTA/Vpu/tetherin complex. Although the results do not provide support for a physiological function of SGTA in HIV-1 replication, they demonstrate that SGTA overexpression regulates tetherin expression and stability, thus providing insights into the function of SGTA in endoplasmic reticulum translocation
Title: The Vpu-interacting Protein SGTA Regulates Expression of a Non-glycosylated Tetherin Species.
study demonstrates a critical role of Hsc70 in SV40 endoplasmic reticulum-to-cytosol penetration and reveal how SGTA controls Hsc70 to impact this process
Title: SGTA-Dependent Regulation of Hsc70 Promotes Cytosol Entry of Simian Virus 40 from the Endoplasmic Reticulum.
the binding of SGTA to Rpn13 enables specific polypeptides to escape proteasomal degradation and/or selectively modulates substrate degradation.
Title: Binding of SGTA to Rpn13 selectively modulates protein quality control.
data suggest that SGTA regulates the cellular fate of a range of hydrophobic polypeptides should they become exposed to the cytosol.
Title: SGTA regulates the cytosolic quality control of hydrophobic substrates.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 release from cells is inhibited by the overexpression of SGTA	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	The enhancement of HIV-1 particle release and Capsid export resulting from the interaction of HIV-1 Vpu with HIV-1 Gag also involves the interaction of both Vpu and Gag with Vpu-binding protein (Ubp; Vpu interactive protein; VIP; SGT; NP_003012)	PubMed
Vpu	vpu	HIV-1 Vpu interacts with SGTA	PubMed
	vpu	Residues 84-210 in SGT and residues 31-35 in HIV-1 Vpu are required for the binding of Vpu to SGT	PubMed
	vpu	Small glutamine-rich tetratricopeptide repeat containing protein, also known as Vpu-binding protein (Ubp) or Vpu interactive protein (VIP), interacts with both HIV-1 Vpu and Gag to play a role in Vpu-mediated enhancement of HIV-1 virion release from cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A007K05 (e-PCR)
- UniSTS:56839

D19S1028 (e-PCR)
- UniSTS:55064

RH11023 (e-PCR)
- UniSTS:33629

RH77778 (e-PCR)
- UniSTS:61673

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables BAT3 complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in tail-anchored membrane protein insertion into ER membrane	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small glutamine-rich tetratricopeptide repeat-containing protein alpha

Names: UBP; alpha-SGT; protein containing three tetratricopeptide repeats; small glutamine rich tetratricopeptide repeat containing alpha; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; viral protein U-binding protein; vpu-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003021.4 → NP_003012.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha

See identical proteins and their annotated locations for NP_003012.1

Status: REVIEWED

Source sequence(s)

AL050156

Consensus CDS

CCDS12094.1

UniProtKB/Swiss-Prot

D6W610, O43765, Q6FIA9, Q9BTZ9

UniProtKB/TrEMBL

A0A7I2V5Z3

Related

ENSP00000221566.1, ENST00000221566.7

Conserved Domains (3) summary

PLN03088
Location:105 → 211

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:91 → 119

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerization domain of SGTA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

2754715..2783273 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011528178.4 → XP_011526480.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

See identical proteins and their annotated locations for XP_011526480.1

UniProtKB/Swiss-Prot

D6W610, O43765, Q6FIA9, Q9BTZ9

UniProtKB/TrEMBL

A0A7I2V5Z3

Related

ENSP00000504495.1, ENST00000676943.1

Conserved Domains (3) summary

PLN03088
Location:105 → 211

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:91 → 119

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerization domain of SGTA

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

2730001..2758560 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321766.1 → XP_054177741.1 small glutamine-rich tetratricopeptide repeat-containing protein alpha isoform X1

UniProtKB/Swiss-Prot

D6W610, O43765, Q6FIA9, Q9BTZ9