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    Apoo apolipoprotein O [ Mus musculus (house mouse) ]

    Gene ID: 68316, updated on 7-May-2024

    Summary

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    Official Symbol
    Apooprovided by MGI
    Official Full Name
    apolipoprotein Oprovided by MGI
    Primary source
    MGI:MGI:1915566
    See related
    Ensembl:ENSMUSG00000079508 AllianceGenome:MGI:1915566
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Micos26; 0610008C08Rik; 1110019O03Rik
    Summary
    Predicted to be involved in cristae formation. Located in mitochondrion. Is expressed in adrenal gland; liver left lobe; and liver right lobe. Orthologous to human APOO (apolipoprotein O). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 13.3), kidney adult (RPKM 6.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Apoo in Genome Data Viewer
    Location:
    X C3; X 41.56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93410615..93460699)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94367010..94417093)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 5 pseudogene Neighboring gene family with sequence similarity 90, member A1B Neighboring gene STARR-positive B cell enhancer ABC_E11051 Neighboring gene M phase phosphoprotein 6 pseudogene Neighboring gene predicted gene 14827 Neighboring gene thrombospondin, type I, domain containing 7B pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function. Tian F, et al. Biochem Biophys Res Commun, 2017 Sep 9. PMID 28647361
    2. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Nijstad N, et al. Biochim Biophys Acta, 2011 Apr. PMID 21296681
    3. Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes. Guo X, et al. Metabolism, 2023 Jul. PMID 37088120
    4. ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart. Lamant M, et al. J Biol Chem, 2006 Nov 24. PMID 16956892
    5. MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. Mostofa MG, et al. J Biol Chem, 2022 Jun. PMID 35460694, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
      Title: Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
    2. Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARalpha-mediated functional interplay between mitochondria and peroxisomes.
      Title: Loss of APOO (MIC26) aggravates obesity-related whitening of brown adipose tissue via PPARα-mediated functional interplay between mitochondria and peroxisomes.
    3. MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
      Title: MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease.
    4. The liver function indices (serum ALT and AST) were clearly elevated, and the ultrastructure of cellular mitochondria was distinctly altered in the liver after apoO overexpression. Further, mitochondrial membrane potential decreased with hApoO treatment in L02 cells.
      Title: Apolipoprotein O expression in mouse liver enhances hepatic lipid accumulation by impairing mitochondrial function.
    5. APOO represents a link between impaired mitochondrial function and cardiomyopathy onset, and targeting APOO-dependent metabolic remodeling has potential as a strategy to adjust heart metabolism and protect the myocardium from impaired contractility.
      Title: Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.
    6. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
      Title: Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice.
    7. apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein
      Title: ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130105, MGC130106

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit Mic26
    Names
    MICOS complex subunit Mic23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199337.1 → NP_001186266.1  MICOS complex subunit Mic26 isoform 2

      See identical proteins and their annotated locations for NP_001186266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' end which utilizes an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer when it is compared to isoform 1.
      Source sequence(s)
      AK002320, DV662362
      Consensus CDS
      CCDS57769.1
      UniProtKB/Swiss-Prot
      Q9DCZ4
      Related
      ENSMUSP00000109530.3, ENSMUST00000113897.9
      Conserved Domains (1) summary
      pfam09769
      Location:55 → 191
      ApoO; Apolipoprotein O

    2. NM_001199338.1 → NP_001186267.1  MICOS complex subunit Mic26 isoform 3

      See identical proteins and their annotated locations for NP_001186267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK002320, AK003831, DV662362
      Consensus CDS
      CCDS57770.1
      UniProtKB/TrEMBL
      Q3KNM9
      Related
      ENSMUSP00000109529.2, ENSMUST00000113896.8
      Conserved Domains (1) summary
      pfam09769
      Location:7 → 143
      ApoO; Apolipoprotein O

    3. NM_001199339.1 → NP_001186268.1  MICOS complex subunit Mic26 isoform 3

      See identical proteins and their annotated locations for NP_001186268.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a different segment for its 5' end which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus when it is compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AK002320, BC016557
      Consensus CDS
      CCDS57770.1
      UniProtKB/TrEMBL
      Q3KNM9
      Related
      ENSMUSP00000109528.2, ENSMUST00000113895.2
      Conserved Domains (1) summary
      pfam09769
      Location:7 → 143
      ApoO; Apolipoprotein O

    4. NM_026673.4 → NP_080949.2  MICOS complex subunit Mic26 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080949.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring transcript. Variant 1 encodes isoform 1.
      Source sequence(s)
      BU534555, CB595096, DV662362, EL957008
      Consensus CDS
      CCDS53136.1
      UniProtKB/Swiss-Prot
      B1ASQ2, B1ASQ3, Q9D186, Q9DCZ4
      UniProtKB/TrEMBL
      Q3KNM9
      Related
      ENSMUSP00000109531.2, ENSMUST00000113898.8
      Conserved Domains (1) summary
      pfam09769
      Location:41 → 177
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93410615..93460699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247666.3 → XP_011245968.1  MICOS complex subunit Mic26 isoform X1

      Conserved Domains (1) summary
      pfam09769
      Location:54 → 177
      ApoO; Apolipoprotein O

    2. XM_011247668.4 → XP_011245970.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245970.1

      Conserved Domains (1) summary
      pfam09769
      Location:20 → 143
      ApoO; Apolipoprotein O

    3. XM_011247667.4 → XP_011245969.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245969.1

      Conserved Domains (1) summary
      pfam09769
      Location:20 → 143
      ApoO; Apolipoprotein O

    4. XM_011247669.3 → XP_011245971.1  MICOS complex subunit Mic26 isoform X2

      See identical proteins and their annotated locations for XP_011245971.1

      Conserved Domains (1) summary
      pfam09769
      Location:20 → 143
      ApoO; Apolipoprotein O
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCZ4.2 GenPept UniProtKB/Swiss-Prot:Q9DCZ4

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