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    Ppcdc phosphopantothenoylcysteine decarboxylase [ Mus musculus (house mouse) ]

    Gene ID: 66812, updated on 12-May-2024

    Summary

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    Official Symbol
    Ppcdcprovided by MGI
    Official Full Name
    phosphopantothenoylcysteine decarboxylaseprovided by MGI
    Primary source
    MGI:MGI:1914062
    See related
    Ensembl:ENSMUSG00000063849 AllianceGenome:MGI:1914062
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810057I13Rik; 8430432M10Rik
    Summary
    Predicted to enable FMN binding activity; identical protein binding activity; and phosphopantothenoylcysteine decarboxylase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be part of phosphopantothenoylcysteine decarboxylase complex. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human PPCDC (phosphopantothenoylcysteine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 6.4), bladder adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppcdc in Genome Data Viewer
    Location:
    9 B; 9 31.04 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57292378..57347440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57385095..57440157, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39343 Neighboring gene STARR-seq mESC enhancer starr_24228 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24229 Neighboring gene RIKEN cDNA 4930430J02 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57269067-57269268 Neighboring gene STARR-seq mESC enhancer starr_24230 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57287043-57287152 Neighboring gene STARR-positive B cell enhancer ABC_E10550 Neighboring gene secretory carrier membrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_24235 Neighboring gene STARR-seq mESC enhancer starr_24236 Neighboring gene DNA segment, Chr 9, Wayne State University 149

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Pathogenic variants of the coenzyme A biosynthesis-associated enzyme phosphopantothenoylcysteine decarboxylase cause autosomal-recessive dilated cardiomyopathy. Bravo-Alonso I, et al. J Inherit Metab Dis, 2023 Mar. PMID 36564894
    2. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Strauss E, et al. Biochemistry, 2004 Dec 14. PMID 15581364
    3. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102190

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantothenoylcysteine decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantothenoylcysteine decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphopantothenoylcysteine decarboxylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphopantothenoylcysteine decarboxylase
    Names
    PPC-DC
    coaC
    NP_001344841.1
    NP_001344842.1
    NP_001344843.1
    NP_001344844.1
    NP_001344845.1
    NP_001344847.1
    NP_789801.1
    XP_006511423.1
    XP_006511424.1
    XP_006511426.1
    XP_006511430.1
    XP_011241092.1
    XP_011241093.1
    XP_011241094.1
    XP_011241095.1
    XP_030100362.1
    XP_030100363.1
    XP_030100364.1
    XP_030100365.1
    XP_036011077.1
    XP_036011078.1
    XP_036011079.1
    XP_036011080.1
    XP_036011081.1
    XP_036011082.1
    XP_036011083.1
    XP_036011084.1
    XP_036011085.1
    XP_036011086.1
    XP_036011087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357912.1 → NP_001344841.1  phosphopantothenoylcysteine decarboxylase isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
      Source sequence(s)
      AC125321
      Consensus CDS
      CCDS23221.1
      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    2. NM_001357913.1 → NP_001344842.1  phosphopantothenoylcysteine decarboxylase isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC125321
      Consensus CDS
      CCDS23221.1
      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    3. NM_001357914.1 → NP_001344843.1  phosphopantothenoylcysteine decarboxylase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC125321, AK038628
      Consensus CDS
      CCDS90580.1
      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Related
      ENSMUSP00000150210.2, ENSMUST00000214144.2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    4. NM_001357915.1 → NP_001344844.1  phosphopantothenoylcysteine decarboxylase isoform c

      Status: VALIDATED

      Source sequence(s)
      AC125321, CK388377
      Conserved Domains (1) summary
      cl19190
      Location:46 → 120
      Flavoprotein

    5. NM_001357916.1 → NP_001344845.1  phosphopantothenoylcysteine decarboxylase isoform d

      Status: VALIDATED

      Source sequence(s)
      AC125321, AK007887
      Consensus CDS
      CCDS90578.1
      UniProtKB/TrEMBL
      A0A1L1SRA4, A0A1L1SUH2
      Related
      ENSMUSP00000150738.2, ENSMUST00000214624.2
      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    6. NM_001357918.1 → NP_001344847.1  phosphopantothenoylcysteine decarboxylase isoform e

      Status: VALIDATED

      Source sequence(s)
      AC125321
      Consensus CDS
      CCDS90579.1
      UniProtKB/TrEMBL
      A0A1L1SQD8, A0A1L1SRA4
      Related
      ENSMUSP00000149007.2, ENSMUST00000214339.2
      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    7. NM_176831.5 → NP_789801.1  phosphopantothenoylcysteine decarboxylase isoform a

      See identical proteins and their annotated locations for NP_789801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
      Source sequence(s)
      AC125321, BC089351
      Consensus CDS
      CCDS23221.1
      UniProtKB/Swiss-Prot
      Q8BZB2
      Related
      ENSMUSP00000082856.5, ENSMUST00000085709.6
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    RNA

    1. NR_152144.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125321

    2. NR_152145.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125321
      Related
      ENSMUST00000216365.2

    3. NR_152146.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC125321, BU694424

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57292378..57347440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155193.1 → XP_036011086.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    2. XM_036155191.1 → XP_036011084.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    3. XM_036155192.1 → XP_036011085.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    4. XM_030244503.2 → XP_030100363.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    5. XM_011242792.2 → XP_011241094.1  phosphopantothenoylcysteine decarboxylase isoform X2

      See identical proteins and their annotated locations for XP_011241094.1

      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Related
      ENSMUSP00000150007.2, ENSMUST00000215961.2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    6. XM_011242790.2 → XP_011241092.1  phosphopantothenoylcysteine decarboxylase isoform X2

      See identical proteins and their annotated locations for XP_011241092.1

      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    7. XM_011242791.2 → XP_011241093.1  phosphopantothenoylcysteine decarboxylase isoform X2

      See identical proteins and their annotated locations for XP_011241093.1

      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    8. XM_036155189.1 → XP_036011082.1  phosphopantothenoylcysteine decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    9. XM_036155190.1 → XP_036011083.1  phosphopantothenoylcysteine decarboxylase isoform X2

      UniProtKB/TrEMBL
      A0A1L1SSQ9, A0A1L1ST77
      Conserved Domains (1) summary
      cl19190
      Location:8 → 120
      Flavoprotein

    10. XM_036155194.1 → XP_036011087.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    11. XM_030244504.2 → XP_030100364.1  phosphopantothenoylcysteine decarboxylase isoform X5

      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    12. XM_006511363.5 → XP_006511426.1  phosphopantothenoylcysteine decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006511426.1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    13. XM_036155184.1 → XP_036011077.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    14. XM_036155185.1 → XP_036011078.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    15. XM_036155186.1 → XP_036011079.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    16. XM_006511360.5 → XP_006511423.1  phosphopantothenoylcysteine decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006511423.1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    17. XM_036155188.1 → XP_036011081.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    18. XM_036155187.1 → XP_036011080.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    19. XM_006511367.5 → XP_006511430.1  phosphopantothenoylcysteine decarboxylase isoform X4

      Conserved Domains (1) summary
      cl19190
      Location:2 → 118
      Flavoprotein

    20. XM_006511361.5 → XP_006511424.1  phosphopantothenoylcysteine decarboxylase isoform X1

      See identical proteins and their annotated locations for XP_006511424.1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    21. XM_030244502.2 → XP_030100362.1  phosphopantothenoylcysteine decarboxylase isoform X1

      UniProtKB/Swiss-Prot
      Q8BZB2
      Conserved Domains (1) summary
      cl19190
      Location:8 → 195
      Flavoprotein

    22. XM_011242793.2 → XP_011241095.1  phosphopantothenoylcysteine decarboxylase isoform X3

      See identical proteins and their annotated locations for XP_011241095.1

      Conserved Domains (1) summary
      cl19190
      Location:46 → 120
      Flavoprotein

    23. XM_030244505.1 → XP_030100365.1  phosphopantothenoylcysteine decarboxylase isoform X6

      UniProtKB/TrEMBL
      A0A1L1SRA4
      Conserved Domains (1) summary
      cl19190
      Location:19 → 42
      Flavoprotein

    RNA

    1. XR_004935519.1 RNA Sequence

    2. XR_003947973.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZB2.1 GenPept UniProtKB/Swiss-Prot:Q8BZB2

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