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    Loxl2 lysyl oxidase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 94352, updated on 12-May-2024

    Summary

    Official Symbol
    Loxl2provided by MGI
    Official Full Name
    lysyl oxidase-like 2provided by MGI
    Primary source
    MGI:MGI:2137913
    See related
    Ensembl:ENSMUSG00000034205 AllianceGenome:MGI:2137913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110004B06Rik; 4930526G11Rik; 9430067E15Rik
    Summary
    Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Involved in negative regulation of stem cell population maintenance; positive regulation of chondrocyte differentiation; and response to hypoxia. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human LOXL2 (lysyl oxidase like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 41.7), ovary adult (RPKM 38.9) and 21 other tissues See more
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    Genomic context

    See Loxl2 in Genome Data Viewer
    Location:
    14 D2; 14 36.06 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69846085..69933283)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69608692..69695834)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41194 Neighboring gene predicted gene 27174 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69942500-69942801 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69943894-69944195 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69955006-69955307 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 4B Neighboring gene predicted gene, 53865 Neighboring gene predicted gene 27177 Neighboring gene STARR-positive B cell enhancer mm9_chr14:69994605-69994905 Neighboring gene STARR-positive B cell enhancer mm9_chr14:70029225-70029526 Neighboring gene microRNA 6950 Neighboring gene STARR-positive B cell enhancer ABC_E4117 Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene charged multivesicular body protein 7 Neighboring gene heat shock protein 1 (chaperonin) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102220

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables copper ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine 6-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-lysine 6-oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heterochromatin organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of stem cell population maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-lysine oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lysyl oxidase homolog 2
    Names
    lysyl oxidase-like protein 2
    NP_201582.2
    XP_006519807.1
    XP_006519810.1
    XP_036014834.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033325.2NP_201582.2  lysyl oxidase homolog 2 precursor

      See identical proteins and their annotated locations for NP_201582.2

      Status: VALIDATED

      Source sequence(s)
      AA437829, AC160639, AK045019, AK159386
      Consensus CDS
      CCDS27241.1
      UniProtKB/Swiss-Prot
      P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39
      Related
      ENSMUSP00000097987.3, ENSMUST00000100420.4
      Conserved Domains (2) summary
      smart00202
      Location:61162
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:550750
      Lysyl_oxidase; Lysyl oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      69846085..69933283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519744.4XP_006519807.1  lysyl oxidase homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_006519807.1

      Conserved Domains (2) summary
      smart00202
      Location:61162
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:557757
      Lysyl_oxidase; Lysyl oxidase
    2. XM_036158941.1XP_036014834.1  lysyl oxidase homolog 2 isoform X2

      Conserved Domains (2) summary
      smart00202
      Location:61162
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:557756
      Lysyl_oxidase; Lysyl oxidase
    3. XM_006519747.3XP_006519810.1  lysyl oxidase homolog 2 isoform X3

      See identical proteins and their annotated locations for XP_006519810.1

      UniProtKB/Swiss-Prot
      P58022, Q8BRE6, Q8BS86, Q8C4K0, Q9JJ39
      Related
      ENSMUSP00000022660.7, ENSMUST00000022660.14
      Conserved Domains (2) summary
      smart00202
      Location:61162
      SR; Scavenger receptor Cys-rich
      pfam01186
      Location:550750
      Lysyl_oxidase; Lysyl oxidase