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    Rpusd4 RNA pseudouridylate synthase domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 71989, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rpusd4provided by MGI
    Official Full Name
    RNA pseudouridylate synthase domain containing 4provided by MGI
    Primary source
    MGI:MGI:1919239
    See related
    Ensembl:ENSMUSG00000032044 AllianceGenome:MGI:1919239
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410001E19Rik
    Summary
    Predicted to enable mitochondrial ribosomal large subunit rRNA binding activity; pseudouridine synthase activity; and tRNA binding activity. Predicted to be involved in enzyme-directed rRNA pseudouridine synthesis; mitochondrial tRNA pseudouridine synthesis; and positive regulation of mitochondrial translation. Predicted to act upstream of or within tRNA processing. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human RPUSD4 (RNA pseudouridine synthase D4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 8.8), limb E14.5 (RPKM 7.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpusd4 in Genome Data Viewer
    Location:
    9 A4; 9 20.15 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35179177..35187253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35267881..35275957)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene STARR-positive B cell enhancer ABC_E10539 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene predicted gene, 33838

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
    2. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitochondrial ribosomal large subunit rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pseudouridylate synthase RPUSD4, mitochondrial
    Names
    RNA pseudouridylate synthase domain-containing protein 4
    mitochondrial RNA pseudouridine synthase Rpusd4
    NP_082316.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028040.2 → NP_082316.1  pseudouridylate synthase RPUSD4, mitochondrial

      See identical proteins and their annotated locations for NP_082316.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061256
      Consensus CDS
      CCDS22962.1
      UniProtKB/Swiss-Prot
      Q9CWX4
      Related
      ENSMUSP00000034543.5, ENSMUST00000034543.5
      Conserved Domains (2) summary
      TIGR00005
      Location:46 → 347
      rluA_subfam; pseudouridine synthase, RluA family
      cd02869
      Location:106 → 329
      PseudoU_synth_RluCD_like; Pseudouridine synthase, RsuA/RluD family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35179177..35187253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CWX4.1 GenPept UniProtKB/Swiss-Prot:Q9CWX4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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