Gphb5 glycoprotein hormone beta 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gphb5provided by MGI
Official Full Name: glycoprotein hormone beta 5provided by MGI
Primary source: MGI:MGI:2156540
See related: Ensembl:ENSMUSG00000048982 AllianceGenome:MGI:2156540
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: OGH; Zlut1
Summary: Predicted to enable protein heterodimerization activity and thyrotropin-releasing hormone receptor binding activity. Acts upstream of or within regulation of thyroid hormone mediated signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Orthologous to human GPHB5 (glycoprotein hormone subunit beta 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 32.71 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (75458494..75463555, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (75411720..75416781, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

expressed in newborn skulls and long bones but declined rapidly thereafter
Title: Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.
lacking GPB5 during acute illness does not affect the LPS-induced decrease of serum thyroid hormones
Title: Thyrostimulin deficiency does not alter peripheral responses to acute inflammation-induced nonthyroidal illness.
Results demonstrate in vivo regulation of central GPB5 transcription during acute illness.
Title: Acute inflammation increases pituitary and hypothalamic glycoprotein hormone subunit B5 mRNA expression in association with decreased thyrotrophin receptor mRNA expression in mice.
when GPB5-TG mice are challenged with a high-fat diet, they gain significantly less weight and body fat than their WT littermates
Title: Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables thyrotropin-releasing hormone receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of thyroid hormone mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of thyroid hormone mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycoprotein hormone beta-5

Names: glycoprotein hormone beta subunit; thyrostimulin subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175644.3 → NP_783575.2 glycoprotein hormone beta-5 precursor

See identical proteins and their annotated locations for NP_783575.2

Status: VALIDATED

Source sequence(s)

AC124414

Consensus CDS

CCDS25982.1

UniProtKB/Swiss-Prot

Q812B2, Q8BJV2

UniProtKB/TrEMBL

B2RTN6, Q2NL39

Related

ENSMUSP00000061488.3, ENSMUST00000051079.4

Conserved Domains (1) summary

cd00069
Location:36 → 129

GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

75458494..75463555 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315024.1 → XP_017170513.1 glycoprotein hormone beta-5 isoform X1

UniProtKB/Swiss-Prot

Q812B2, Q8BJV2

UniProtKB/TrEMBL

B2RTN6, Q2NL39

Conserved Domains (1) summary

cd00069
Location:36 → 129

GHB_like; Glycoprotein hormone beta chain homologues