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    Ifit1bl1 interferon induced protein with tetratricpeptide repeats 1B like 1 [ Mus musculus (house mouse) ]

    Gene ID: 667373, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ifit1bl1provided by MGI
    Official Full Name
    interferon induced protein with tetratricpeptide repeats 1B like 1provided by MGI
    Primary source
    MGI:MGI:3650685
    See related
    Ensembl:ENSMUSG00000079339 AllianceGenome:MGI:3650685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ifit1c; Gm14446
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in defense response to virus. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to several human genes including IFIT1B (interferon induced protein with tetratricopeptide repeats 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 11.1), colon adult (RPKM 4.8) and 4 other tissues See more
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    Genomic context

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    See Ifit1bl1 in Genome Data Viewer
    Location:
    19 C1; 19 29.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34570288..34640382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34592888..34662981, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4275 Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3B Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45998 Neighboring gene interferon-induced protein with tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E9997 Neighboring gene STARR-seq mESC enhancer starr_46000 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene predicted gene, 18425

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c. Mears HV, et al. J Biol Chem, 2020 Dec 18. PMID 33454014, Free PMC Article
    2. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
    3. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
    4. Postnatal gene expression in the normal mouse cornea by SAGE. Norman B, et al. Invest Ophthalmol Vis Sci, 2004 Feb. PMID 14744882
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
      Title: Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon induced protein with tetratricpeptide repeats 1B like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101605.1 → NP_001095075.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' end exon compared to transcript variant 1, and encodes an isoform (2), which is the same length but differs by a single aa compared to isoform 1.
      Source sequence(s)
      AA175618, AC016791, BQ553020, BX515248, BY154335, DV551663
      Consensus CDS
      CCDS50422.1
      UniProtKB/TrEMBL
      E9PXF7
      Related
      ENSMUSP00000132781.2, ENSMUST00000168254.3
      Conserved Domains (5) summary
      sd00006
      Location:249 → 277
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:323 → 368
      TPR_11; TPR repeat
      pfam13424
      Location:62 → 132
      TPR_12; Tetratricopeptide repeat
      pfam13432
      Location:153 → 215
      TPR_16; Tetratricopeptide repeat
      cl21625
      Location:330 → 434
      Capsule_synth; Capsule polysaccharide biosynthesis protein

    2. NM_001110517.1 → NP_001103987.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform 1

      See identical proteins and their annotated locations for NP_001103987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AA175618, AA290456, AC016791, BB575849, BQ553020, BX515248, BY094379, DV551663
      Consensus CDS
      CCDS50421.1
      UniProtKB/TrEMBL
      D3Z6F0
      Related
      ENSMUSP00000108086.2, ENSMUST00000112467.2
      Conserved Domains (2) summary
      TIGR02917
      Location:63 → 468
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:249 → 277
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34570288..34640382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527265.5 → XP_006527328.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform X2

      Conserved Domains (2) summary
      TIGR02917
      Location:23 → 428
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:209 → 237
      TPR; TPR repeat [structural motif]

    2. XM_030251031.2 → XP_030106891.1  interferon induced protein with tetratricpeptide repeats 1B like 1 isoform X1

      UniProtKB/TrEMBL
      D3Z6F0
      Conserved Domains (2) summary
      TIGR02917
      Location:63 → 468
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:249 → 277
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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