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    Klhdc8b kelch domain containing 8B [ Mus musculus (house mouse) ]

    Gene ID: 78267, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhdc8bprovided by MGI
    Official Full Name
    kelch domain containing 8Bprovided by MGI
    Primary source
    MGI:MGI:1925517
    See related
    Ensembl:ENSMUSG00000032609 AllianceGenome:MGI:1925517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4931406O17Rik
    Summary
    Predicted to be involved in mitotic cytokinetic process; mitotic nuclear division; and nuclear chromosome segregation. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including cellularization cleavage furrow; intercellular bridge; and midbody. Is expressed in heart. Human ortholog(s) of this gene implicated in Hodgkin's lymphoma. Orthologous to human KLHDC8B (kelch domain containing 8B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 16.4), ovary adult (RPKM 13.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhdc8b in Genome Data Viewer
    Location:
    9 F2; 9 59.37 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108324834..108338780, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108447635..108461581, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interactor of HORMAD1 1 Neighboring gene predicted gene, 25456 Neighboring gene cDNA sequence BC048562 Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206 Neighboring gene laminin, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Efficient capture of cardiogenesis-associated genes expressed in ES cells. Terami H, et al. Biochem Biophys Res Commun, 2007 Mar 30. PMID 17286962
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellularization cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellularization cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intercellular bridge IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 8B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359428.1 → NP_001346357.1  kelch domain-containing protein 8B

      Status: VALIDATED

      Source sequence(s)
      AC161260
      Consensus CDS
      CCDS23526.1
      UniProtKB/Swiss-Prot
      Q9D2D9
      Related
      ENSMUSP00000035232.8, ENSMUST00000035232.13
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    2. NM_030075.2 → NP_084351.1  kelch domain-containing protein 8B

      See identical proteins and their annotated locations for NP_084351.1

      Status: VALIDATED

      Source sequence(s)
      AK019849, CA750541
      Consensus CDS
      CCDS23526.1
      UniProtKB/Swiss-Prot
      Q9D2D9
      Related
      ENSMUSP00000142325.2, ENSMUST00000193286.6
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108324834..108338780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244718.2 → XP_030100578.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    2. XM_030244724.2 → XP_030100584.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    3. XM_030244721.2 → XP_030100581.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    4. XM_030244716.2 → XP_030100576.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Related
      ENSMUSP00000141453.2, ENSMUST00000193895.6
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    5. XM_036155408.1 → XP_036011301.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    6. XM_030244719.2 → XP_030100579.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    7. XM_030244723.2 → XP_030100583.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    8. XM_030244717.2 → XP_030100577.1  kelch domain-containing protein 8B isoform X1

      UniProtKB/Swiss-Prot
      Q9D2D9
      Conserved Domains (2) summary
      PHA03098
      Location:7 → 210
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:69 → 113
      Kelch; KELCH repeat [structural motif]

    9. XM_030244725.1 → XP_030100585.1  kelch domain-containing protein 8B isoform X2

      Conserved Domains (2) summary
      PHA03098
      Location:2 → 209
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:39 → 81
      Kelch; KELCH repeat [structural motif]

    10. XM_006511858.3 → XP_006511921.1  kelch domain-containing protein 8B isoform X2

      See identical proteins and their annotated locations for XP_006511921.1

      Conserved Domains (2) summary
      PHA03098
      Location:2 → 209
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:39 → 81
      Kelch; KELCH repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2D9.1 GenPept UniProtKB/Swiss-Prot:Q9D2D9

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