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    METTL16 methyltransferase 16, RNA N6-adenosine [ Homo sapiens (human) ]

    Gene ID: 79066, updated on 23-May-2024

    Summary

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    Official Symbol
    METTL16provided by HGNC
    Official Full Name
    methyltransferase 16, RNA N6-adenosineprovided by HGNC
    Primary source
    HGNC:HGNC:28484
    See related
    Ensembl:ENSG00000127804 AllianceGenome:HGNC:28484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    METT10D
    Summary
    Enables RNA binding activity and RNA methyltransferase activity. Involved in RNA modification and regulation of mRNA metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 7.5), thyroid (RPKM 6.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See METTL16 in Genome Data Viewer
    Location:
    17p13.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (2415715..2511888, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (2304395..2400696, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (2319343..2415182, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2289277-2290101 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2291629-2292130 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296137-2296704 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2296705-2297271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2301897-2302468 Neighboring gene hESC enhancers GRCh37_chr17:2302469-2303038 and GRCh37_chr17:2303039-2303609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11493 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2305321-2305891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2305892-2306461 Neighboring gene MAX network transcriptional repressor Neighboring gene uncharacterized LOC284009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337127-2337806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2337807-2338485 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2338486-2339164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2339165-2339843 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:2383040-2383219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:2398718-2399218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2403917-2404418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2404419-2404918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2409238-2410149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:2410150-2411060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11496 Neighboring gene MPRA-validated peak2683 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:2453840-2454586 Neighboring gene RNA, 7SL, cytoplasmic 33, pseudogene Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. METTL16 promotes glycolytic metabolism reprogramming and colorectal cancer progression. Wei W, et al. J Exp Clin Cancer Res, 2023 Jun 20. PMID 37340443, Free PMC Article
    2. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Han L, et al. Cell Stem Cell, 2023 Jan 5. PMID 36608679, Free PMC Article
    3. Elucidating the Kinetic Mechanism of Human METTL16. Breger K, et al. Biochemistry, 2023 Jan 17. PMID 36584291, Free PMC Article
    4. Clinical Significance of Methyltransferase-like 16 Expression in Epithelial Ovarian Cancer. Li C, et al. J Coll Physicians Surg Pak, 2022 Dec. PMID 36474378
    5. METTL16 epigenetically enhances GPX4 expression via m6A modification to promote breast cancer progression by inhibiting ferroptosis. Ye F, et al. Biochem Biophys Res Commun, 2023 Jan 1. PMID 36434904

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.
      Title: METTL16-mediated N6-methyladenosine modification of Soga1 enables proper chromosome segregation and chromosomal stability in colorectal cancer.
    2. METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m[6] A-dependent manner.
      Title: METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m(6) A-dependent manner.
    3. METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
      Title: METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway.
    4. Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).
      Title: Targeting key RNA methylation enzymes to improve the outcome of colorectal cancer chemotherapy (Review).
    5. METTL16 inhibits papillary thyroid cancer tumorigenicity through m[6]A/YTHDC2/SCD1-regulated lipid metabolism.
      Title: METTL16 inhibits papillary thyroid cancer tumorigenicity through m(6)A/YTHDC2/SCD1-regulated lipid metabolism.
    6. METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
      Title: METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
    7. METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/beta-Catenin Axis.
      Title: METTL16 Inhibits the Malignant Progression of Epithelial Ovarian Cancer through the lncRNA MALAT1/β-Catenin Axis.
    8. The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
      Title: The RNA methyltransferase METTL16 enhances cholangiocarcinoma growth through PRDM15-mediated FGFR4 expression.
    9. Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
      Title: Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of MAT2A by METTL16.
    10. METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
      Title: METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3329

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 23S rRNA (adenine(1618)-N(6))-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA stem-loop binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U6 snRNA (adenine-(43)-N(6))-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U6 snRNA 3'-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA m(6)A methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of S-adenosylmethionine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA (adenine-N6)-methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA N6-adenosine-methyltransferase METTL16
    Names
    N6-adenosine-methyltransferase METTL16
    N6-methyladenosine methyltransferase
    U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
    U6 snRNA methyltransferase
    methyltransferase 10 domain containing
    methyltransferase 10 domain-containing protein
    methyltransferase 16, N6-methyladenosine
    methyltransferase like 16
    methyltransferase-like protein 16
    putative methyltransferase METT10D
    NP_076991.3
    XP_024306696.1
    XP_047292653.1
    XP_047292654.1
    XP_054173101.1
    XP_054173102.1
    XP_054173103.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024086.4 → NP_076991.3  RNA N6-adenosine-methyltransferase METTL16

      See identical proteins and their annotated locations for NP_076991.3

      Status: VALIDATED

      Source sequence(s)
      AC006435, BC050603, DB227557
      Consensus CDS
      CCDS42232.1
      UniProtKB/Swiss-Prot
      D3DTI8, Q86TE5, Q86W50, Q96T16, Q9BVG7
      Related
      ENSP00000263092.5, ENST00000263092.11
      Conserved Domains (1) summary
      pfam05971
      Location:40 → 291
      Methyltransf_10; Protein of unknown function (DUF890)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      2415715..2511888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436697.1 → XP_047292653.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

      Related
      ENST00000571669.6

    2. XM_047436698.1 → XP_047292654.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7

    3. XM_024450928.2 → XP_024306696.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7
      Conserved Domains (2) summary
      pfam02063
      Location:189 → 284
      MARCKS; MARCKS family
      cl17173
      Location:1 → 73
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_007065448.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      2304395..2400696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317126.1 → XP_054173101.1  RNA N6-adenosine-methyltransferase METTL16 isoform X1

    2. XM_054317127.1 → XP_054173102.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7

    3. XM_054317128.1 → XP_054173103.1  RNA N6-adenosine-methyltransferase METTL16 isoform X2

      UniProtKB/TrEMBL
      B7Z3X7

    RNA

    1. XR_008484933.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86W50.2 GenPept UniProtKB/Swiss-Prot:Q86W50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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