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    RPA4 replication protein A4 [ Homo sapiens (human) ]

    Gene ID: 29935, updated on 23-Mar-2024

    Summary

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    Official Symbol
    RPA4provided by HGNC
    Official Full Name
    replication protein A4provided by HGNC
    Primary source
    HGNC:HGNC:30305
    See related
    Ensembl:ENSG00000204086 MIM:300767; AllianceGenome:HGNC:30305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSU24186
    Summary
    This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]
    Orthologs
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    Genomic context

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    See RPA4 in Genome Data Viewer
    Location:
    Xq21.33
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (96883908..96885467)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (95323189..95324748)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (96138907..96140466)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985714 Neighboring gene uncharacterized LOC105373296 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:95939629-95940344 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:95940345-95941058 Neighboring gene SKP2 pseudogene 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:95985965-95986513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29796 Neighboring gene diaphanous related formin 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:96070182-96070682 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:96070683-96071183 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29798 Neighboring gene NADH:ubiquinone oxidoreductase subunit B5 pseudogene 2 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:96282448-96283050 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:96374110-96375309 Neighboring gene uncharacterized LOC124905287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression. Haring SJ, et al. Nucleic Acids Res, 2010 Jan. PMID 19942684, Free PMC Article
    2. An alternative form of replication protein a prevents viral replication in vitro. Mason AC, et al. J Biol Chem, 2009 Feb 20. PMID 19116208, Free PMC Article
    3. Functions of alternative replication protein A in initiation and elongation. Mason AC, et al. Biochemistry, 2010 Jul 20. PMID 20545304, Free PMC Article
    4. Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. Zhao J, et al. Nucleic Acids Res, 2009 Jul. PMID 19468048, Free PMC Article
    5. An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair. Li L, et al. Mol Cell Biol, 1995 Oct. PMID 7565690, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings provide the first direct evidence for the function of alternative form of RPA in human DNA metabolism and support a model for aRPA functioning in chromosome maintenance functions in nonproliferating cells.
      Title: An alternative form of replication protein a expressed in normal human tissues supports DNA repair.
    2. Results suggest that RPA4 cannot support cell proliferation but can support processes that maintain the genomic integrity of the cell.
      Title: A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression.
    3. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic susceptibility to distinct bladder cancer subphenotypes.
    5. Hyperphosphorylated replication protein A is preferentially localized to double-stranded break repair and the DNA damage checkpoint complexes in response to DNA damage.
      Title: Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    reverse transcriptase gag-pol Replication protein A and HIV-1 nucleocapsid protein interfere with the strand displacement DNA synthesis of HIV-1 reverse transcriptase by binding to the displaced strand and keeping it away from the newly synthesized strand PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: DIAPH2

    Homology

    Clone Names

    • MGC120333, MGC120334

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in nuclear DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication factor A complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A 30 kDa subunit
    Names
    RF-A protein 4
    RP-A p30
    replication factor A protein 4
    replication protein A complex 34 kd subunit homolog Rpa4
    replication protein A4, 30kDa
    replication protein A4, 34kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013259.2 RefSeqGene

      Range
      4896..6455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_013347.4 → NP_037479.1  replication protein A 30 kDa subunit

      See identical proteins and their annotated locations for NP_037479.1

      Status: REVIEWED

      Source sequence(s)
      BC069791, U24186, Z86061
      Consensus CDS
      CCDS35345.1
      UniProtKB/Swiss-Prot
      Q13156, Q3SY03
      Related
      ENSP00000362131.3, ENST00000373040.4
      Conserved Domains (2) summary
      cd04478
      Location:73 → 166
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      cl27871
      Location:32 → 259
      RPA_C; Replication protein A C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      96883908..96885467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      95323189..95324748
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13156.2 GenPept UniProtKB/Swiss-Prot:Q13156

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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