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    Pcdhb5 protocadherin beta 5 [ Mus musculus (house mouse) ]

    Gene ID: 93876, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcdhb5provided by MGI
    Official Full Name
    protocadherin beta 5provided by MGI
    Primary source
    MGI:MGI:2136739
    See related
    Ensembl:ENSMUSG00000063687 AllianceGenome:MGI:2136739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PcdhbE; Pcdhb4A
    Summary
    Predicted to be involved in cell adhesion. Predicted to be integral component of plasma membrane. Is expressed in central nervous system and retina. Orthologous to human PCDHB4 (protocadherin beta 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Pcdhb5 in Genome Data Viewer
    Location:
    18 B3; 18 19.47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (37453434..37456966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (37320381..37323913)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene protocadherin alpha 4B Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene RAD18 homolog pseudogene Neighboring gene protocadherin beta 4 Neighboring gene protocadherin beta 6 Neighboring gene protocadherin beta 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct and Cooperative Functions for the Protocadherin-α, -β and -γ Clusters in Neuronal Survival and Axon Targeting. Hasegawa S, et al. Front Mol Neurosci, 2016. PMID 28066179, Free PMC Article
    2. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Junghans D, et al. Eur J Neurosci, 2008 Feb. PMID 18279309
    3. The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. Vanhalst K, et al. FEBS Lett, 2001 Apr 20. PMID 11322959
    4. Epigenetic functions of smchd1 repress gene clusters on the inactive X chromosome and on autosomes. Gendrel AV, et al. Mol Cell Biol, 2013 Aug. PMID 23754746, Free PMC Article
    5. CTCF Governs the Identity and Migration of MGE-Derived Cortical Interneurons. Elbert A, et al. J Neurosci, 2019 Jan 2. PMID 30377227, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protocadherin beta 5
    Names
    Protocadherin-betaE
    cell-cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053130.3 → NP_444360.1  protocadherin beta 5 precursor

      See identical proteins and their annotated locations for NP_444360.1

      Status: VALIDATED

      Source sequence(s)
      AK028661, AK049825
      Consensus CDS
      CCDS29173.1
      UniProtKB/TrEMBL
      Q8CEA8, Q91XZ5
      Related
      ENSMUSP00000077389.3, ENSMUST00000078271.4
      Conserved Domains (3) summary
      cd11304
      Location:245 → 342
      Cadherin_repeat; Cadherin tandem repeat domain
      pfam08266
      Location:29 → 111
      Cadherin_2; Cadherin-like
      pfam16492
      Location:687 → 769
      Cadherin_C_2; Cadherin cytoplasmic C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      37453434..37456966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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