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    Neurl1b neuralized E3 ubiquitin protein ligase 1B [ Mus musculus (house mouse) ]

    Gene ID: 240055, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Neurl1bprovided by MGI
    Official Full Name
    neuralized E3 ubiquitin protein ligase 1Bprovided by MGI
    Primary source
    MGI:MGI:3643092
    See related
    Ensembl:ENSMUSG00000034413 AllianceGenome:MGI:3643092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG240055; C230078M08Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in ubiquitin-dependent endocytosis. Located in early endosome. Is expressed in several structures, including alimentary system; brain; ganglia; spinal cord; and urinary system. Orthologous to human NEURL1B (neuralized E3 ubiquitin protein ligase 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 22.7), adrenal adult (RPKM 21.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Neurl1b in Genome Data Viewer
    Location:
    17 A3.3; 17 13.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26633833..26665295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26414859..26446321)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hemoglobin alpha, pseudogene 4 Neighboring gene predicted gene, 50015 Neighboring gene STARR-seq mESC enhancer starr_42122 Neighboring gene predicted gene, 34455 Neighboring gene STARR-seq mESC enhancer starr_42124 Neighboring gene STARR-seq mESC enhancer starr_42125 Neighboring gene STARR-seq mESC enhancer starr_42126 Neighboring gene STARR-positive B cell enhancer ABC_E5582 Neighboring gene dual specificity phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. Rullinkov G, et al. Biochem Biophys Res Commun, 2009 Nov 20. PMID 19723503
    2. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. Song R, et al. J Biol Chem, 2006 Nov 24. PMID 17003037
    3. An obligatory role of mind bomb-1 in notch signaling of mammalian development. Koo BK, et al. PLoS One, 2007 Nov 28. PMID 18043734, Free PMC Article
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183766, MGC183777

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEURL1B
    Names
    RING-type E3 ubiquitin transferase NEURL1B
    neuralized homolog 1b
    neuralized-like protein 1B
    NP_001075125.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081656.3 → NP_001075125.1  E3 ubiquitin-protein ligase NEURL1B

      See identical proteins and their annotated locations for NP_001075125.1

      Status: VALIDATED

      Source sequence(s)
      AC157598
      Consensus CDS
      CCDS37513.1
      UniProtKB/Swiss-Prot
      C9DQJ8, Q0MW30
      Related
      ENSMUSP00000051481.7, ENSMUST00000053020.8
      Conserved Domains (4) summary
      smart00588
      Location:40 → 159
      NEUZ; domain in neuralized proteins
      pfam07177
      Location:41 → 106
      Neuralized; Neuralized
      pfam13920
      Location:490 → 540
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl02614
      Location:40 → 189
      SPRY; SPRY domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26633833..26665295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0MW30.1 GenPept UniProtKB/Swiss-Prot:Q0MW30

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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