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    CMTM5 CKLF like MARVEL transmembrane domain containing 5 [ Homo sapiens (human) ]

    Gene ID: 116173, updated on 2-May-2024

    Summary

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    Official Symbol
    CMTM5provided by HGNC
    Official Full Name
    CKLF like MARVEL transmembrane domain containing 5provided by HGNC
    Primary source
    HGNC:HGNC:19176
    See related
    Ensembl:ENSG00000166091 MIM:607888; AllianceGenome:HGNC:19176
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKLFSF5
    Summary
    This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in brain (RPKM 15.6), bone marrow (RPKM 1.3) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q11.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23376771..23379772)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17577688..17580788)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23846255..23848981)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832478-23832978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832979-23833479 Neighboring gene embryonal Fyn-associated substrate Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8171 Neighboring gene interleukin 25 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23854904-23856103 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858153-23858756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23858757-23859360 Neighboring gene myosin heavy chain 6 Neighboring gene microRNA 208a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871133-23871675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23871676-23872217 Neighboring gene VISTA enhancer hs2155 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:23884455-23885654 Neighboring gene myosin heavy chain 7 Neighboring gene myosin heavy chain associated RNA transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway. Li L, et al. Mol Med Rep, 2022 Jan. PMID 34791506, Free PMC Article
    2. [Association between CMTM5 gene and coronary artery disease and the relative mechanism]. Liu TF, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2020 Dec 18. PMID 33331317, Free PMC Article
    3. [Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug-eluting stent implantation and the effects and mechanisms of CMTM5 on human vascular endothelial cells]. Liu TF, et al. Beijing Da Xue Xue Bao Yi Xue Ban, 2020 Oct 18. PMID 33047719, Free PMC Article
    4. [Pathophysiologic mechanism of CMTM5 low expression in multiple myeloma progression]. Ma Y, et al. Zhonghua Xue Ye Xue Za Zhi, 2019 Jan 14. PMID 30704230, Free PMC Article
    5. Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function. Zhang JW, et al. Gene, 2017 Aug 15. PMID 28457985

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway.
      Title: CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway.
    2. CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
      Title: CMTM5/7 are biomarkers and prognostic factors in human breast carcinoma.
    3. [Association between CMTM5 gene and coronary artery disease and the relative mechanism].
      Title: [Association between CMTM5 gene and coronary artery disease and the relative mechanism].
    4. [Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug-eluting stent implantation and the effects and mechanisms of CMTM5 on human vascular endothelial cells].
      Title: [Association of CMTM5 gene expression with the risk of in-stent restenosis in patients with coronary artery disease after drug-eluting stent implantation and the effects and mechanisms of CMTM5 on human vascular endothelial cells].
    5. CMTM5 was down-regulated in the hepatocellular carcinoma tissues.Up-regulation of miR-10b-3p promoted the progression of the hepatocellular carcinoma cells via targeting CMTM5.
      Title: Up-regulation of miR-10b-3p promotes the progression of hepatocellular carcinoma cells via targeting CMTM5.
    6. Re-expression of CMTM5 inhibits the proliferative activity of U266
      Title: [Pathophysiologic mechanism of CMTM5 low expression in multiple myeloma progression].
    7. Overexpression of CMTM5 attenuated vascular endothelial cells migration and proliferation.
      Title: Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function.
    8. results indicate that CMTM5 is down-regulated in prostate cancer and exhibit tumor suppressor activities in androgen-independent prostate cancer cells
      Title: CMTM5 is reduced in prostate cancer and inhibits cancer cell growth in vitro and in vivo.
    9. In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis.
      Title: CMTM5 exhibits tumor suppressor activity through promoter methylation in oral squamous cell carcinoma.
    10. The reduced expression of CMTM5 correlates significantly with poorly differentiated ovarian cancer and high preoperative CA125 level.
      Title: Reduced CMTM5 expression correlates with carcinogenesis in human epithelial ovarian cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ37521

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 5
    Names
    chemokine-like factor super family 5
    chemokine-like factor superfamily member 5

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037288.2 → NP_001032365.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform c

      See identical proteins and their annotated locations for NP_001032365.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a.
      Source sequence(s)
      AF479262, AY820135, BC013109
      Consensus CDS
      CCDS32050.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000372259.2, ENST00000382809.2
      Conserved Domains (1) summary
      cl04571
      Location:29 → 105
      MARVEL; Membrane-associating domain

    2. NM_001288744.2 → NP_001275673.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform d

      See identical proteins and their annotated locations for NP_001275673.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
      Source sequence(s)
      AF527949
      Consensus CDS
      CCDS73618.1
      UniProtKB/TrEMBL
      C9JAI6
      Related
      ENSP00000380404.3, ENST00000397227.7

    3. NM_001288745.2 → NP_001275674.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform e

      See identical proteins and their annotated locations for NP_001275674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
      Source sequence(s)
      AF527948
      Consensus CDS
      CCDS73619.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000344160.4, ENST00000342473.8

    4. NM_001288746.2 → NP_001275675.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform f

      See identical proteins and their annotated locations for NP_001275675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (f) is longer, compared to isoform a.
      Source sequence(s)
      AF527413
      Consensus CDS
      CCDS73617.1
      UniProtKB/Swiss-Prot
      E9PH91, Q5PY48, Q96DZ9
      Related
      ENSP00000344819.4, ENST00000339180.9
      Conserved Domains (1) summary
      pfam01284
      Location:29 → 152
      MARVEL; Membrane-associating domain

    5. NM_138460.3 → NP_612469.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform a

      See identical proteins and their annotated locations for NP_612469.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AL049829
      Consensus CDS
      CCDS9598.1
      UniProtKB/Swiss-Prot
      Q96DZ9
      Related
      ENSP00000352270.3, ENST00000359320.7
      Conserved Domains (1) summary
      pfam01284
      Location:29 → 139
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23376771..23379772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430907.1 → XP_047286863.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    2. XM_047430906.1 → XP_047286862.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

      Related
      ENSP00000497215.1, ENST00000649278.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17577688..17580788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375326.1 → XP_054231301.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    2. XM_054375327.1 → XP_054231302.1  CKLF-like MARVEL transmembrane domain-containing protein 5 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181618.1: Suppressed sequence

      Description
      NM_181618.1: This RefSeq was permanently suppressed because it represents a likely non-sense mediated decay (NMD) candidate, there is insufficient support for the transcript and the protein is not supported by current protein hom
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DZ9.2 GenPept UniProtKB/Swiss-Prot:Q96DZ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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