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    DMTF1 cyclin D binding myb like transcription factor 1 [ Homo sapiens (human) ]

    Gene ID: 9988, updated on 2-May-2024

    Summary

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    Official Symbol
    DMTF1provided by HGNC
    Official Full Name
    cyclin D binding myb like transcription factor 1provided by HGNC
    Primary source
    HGNC:HGNC:14603
    See related
    Ensembl:ENSG00000135164 MIM:608491; AllianceGenome:HGNC:14603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DMP1; DMTF; MRUL; hDMP1
    Summary
    This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
    Expression
    Ubiquitous expression in testis (RPKM 18.8), lymph node (RPKM 11.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DMTF1 in Genome Data Viewer
    Location:
    7q21.12
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (87152453..87196325)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (88402370..88446262)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (86781769..86825641)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578298-86578835 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86578836-86579372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26225 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18340 Neighboring gene MPRA-validated peak6623 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:86687932-86688432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18342 Neighboring gene MPRA-validated peak6624 silencer Neighboring gene uncharacterized LOC124901689 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:86758408-86759168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26226 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86780839-86781402 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:86781403-86781964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18343 Neighboring gene DMTF1 antisense RNA 1 Neighboring gene uncharacterized LOC105375384 Neighboring gene NANOG hESC enhancer GRCh37_chr7:86830979-86831516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18345 Neighboring gene transmembrane protein 243 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:86959096-86960295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18346 Neighboring gene TP53 target 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α. Li J, et al. Int J Oncol, 2021 Jan. PMID 33367929, Free PMC Article
    2. Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression. Niklaus NJ, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30100063
    3. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. Tian N, et al. Int J Mol Sci, 2017 Mar 2. PMID 28257090, Free PMC Article
    4. Role of DMP1 and its future in lung cancer diagnostics. Sugiyama T, et al. Expert Rev Mol Diagn, 2008 Jul. PMID 18598225, Free PMC Article
    5. Emerging roles of DMP1 in lung cancer. Inoue K, et al. Cancer Res, 2008 Jun 15. PMID 18559489, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanisms regulating DMTF1beta/gamma expression and their functional interplay with DMTF1alpha.
      Title: Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α.
    2. Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
      Title: Survival of Lung Cancer Patients Dependent on the LOH Status for DMP1, ARF, and p53.
    3. the results of the study demonstrated that miR6753p directly regulated the expression of DMTF1, which contributed to the further regulation of Colorectal cancer cell proliferation.
      Title: miR‑675 promotes colorectal cancer cell growth dependent on tumor suppressor DMTF1.
    4. DMTF1 is hemizygously deleted in 35-42% of human cancers and is associated with longer survival. [review]
      Title: c-MYB and DMTF1 in Cancer.
    5. Cisplatin sensitivity in breast cancer cells is associated with a DMTF1beta splice variant expression.
      Title: Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression.
    6. Study demonstrated that an alternative cyclin D-binding myb-like transcription factor 1 (DMTF1) pre-mRNA splicing isoform, DMTF1 beta, is increasingly expressed in breast cancer and promotes mammary tumorigenesis in a transgenic mouse model. [review].
      Title: From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform.
    7. Low DMTF1 expression is associated with in bladder cancer.
      Title: MicroRNA-155 promotes bladder cancer growth by repressing the tumor suppressor DMTF1.
    8. findings imply that DMP1alpha- and beta-ratios are tightly regulated in hematopoietic cells and DMP1beta antagonizes DMP1alpha transcriptional regulation of ARF resulting in the alteration of cellular control with a gain in proliferation
      Title: Human DMTF1β antagonizes DMTF1α regulation of the p14(ARF) tumor suppressor and promotes cellular proliferation.
    9. This study reveals a pivotal role of combined Dmp1 loss and cyclin D1 overexpression in breast cancer.
      Title: Cooperation between Dmp1 loss and cyclin D1 overexpression in breast cancer.
    10. LOH for hDMP1 was associated with luminal A category and longer relapse-free survival
      Title: Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25188, FLJ41265, FLJ76054

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-D-binding Myb-like transcription factor 1
    Names
    cyclin D-binding Myb-like protein
    cyclin-D-interacting Myb-like protein 1
    hDMTF1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029536.1 RefSeqGene

      Range
      5093..48965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142326.2 → NP_001135798.1  cyclin-D-binding Myb-like transcription factor 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks a 5' coding exon, compared to variant 1. These differences cause translation initiation at a downstream AUG and an isoform (b) with a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AC005076, AF052102, AK296211, BC070064
      Consensus CDS
      CCDS47633.1
      UniProtKB/TrEMBL
      E7EPA0
      Related
      ENSP00000412532.2, ENST00000432937.6
      Conserved Domains (4) summary
      smart00717
      Location:186 → 242
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:250 → 300
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:186 → 241
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:140 → 196
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. NM_001142327.2 → NP_001135799.1  cyclin-D-binding Myb-like transcription factor 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AF084530, BC007418
      Consensus CDS
      CCDS5601.1
      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Related
      ENSP00000332171.7, ENST00000331242.12
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    3. NM_021145.4 → NP_066968.3  cyclin-D-binding Myb-like transcription factor 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a, also known as DMP1alpha). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AC005076, BC007447, BC070064, DB061156
      Consensus CDS
      CCDS5601.1
      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Related
      ENSP00000378193.5, ENST00000394703.9
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    RNA

    1. NR_024549.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF202145, BC007418
      Related
      ENST00000447863.5

    2. NR_024550.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate internal exons and uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as in variant 1, would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF202144, BC007418
      Related
      ENST00000579677.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      87152453..87196325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421106.1 → XP_047277062.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    2. XM_047421102.1 → XP_047277058.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    3. XM_047421123.1 → XP_047277079.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    4. XM_047421100.1 → XP_047277056.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    5. XM_024447017.2 → XP_024302785.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    6. XM_047421107.1 → XP_047277063.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    7. XM_047421111.1 → XP_047277067.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    8. XM_047421103.1 → XP_047277059.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    9. XM_024447018.2 → XP_024302786.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    10. XM_047421116.1 → XP_047277072.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    11. XM_024447022.2 → XP_024302790.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    12. XM_047421131.1 → XP_047277087.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    13. XM_024447016.2 → XP_024302784.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    14. XM_047421126.1 → XP_047277082.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    15. XM_047421119.1 → XP_047277075.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    16. XM_047421133.1 → XP_047277089.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    17. XM_011516737.1 → XP_011515039.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    18. XM_017012868.1 → XP_016868357.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      COG5147
      Location:105 → 438
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain

    19. XM_047421118.1 → XP_047277074.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    20. XM_047421134.1 → XP_047277090.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    21. XM_024447020.2 → XP_024302788.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    22. XM_047421128.1 → XP_047277084.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    23. XM_047421117.1 → XP_047277073.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    24. XM_047421122.1 → XP_047277078.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    25. XM_011516739.4 → XP_011515041.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (4) summary
      smart00717
      Location:233 → 289
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:297 → 347
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:233 → 288
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:187 → 243
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    26. XM_017012870.3 → XP_016868359.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

      UniProtKB/TrEMBL
      E7EPA0

    27. XM_047421108.1 → XP_047277064.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    28. XM_047421101.1 → XP_047277057.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    29. XM_047421104.1 → XP_047277060.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    30. XM_047421125.1 → XP_047277081.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    31. XM_024447019.2 → XP_024302787.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    32. XM_047421120.1 → XP_047277076.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    33. XM_047421112.1 → XP_047277068.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    34. XM_047421105.1 → XP_047277061.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    35. XM_047421127.1 → XP_047277083.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    36. XM_024447021.2 → XP_024302789.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222
      UniProtKB/TrEMBL
      E7EPA0
      Conserved Domains (3) summary
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      cl28544
      Location:89 → 438
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

    37. XM_047421130.1 → XP_047277086.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    38. XM_047421121.1 → XP_047277077.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    39. XM_047421099.1 → XP_047277055.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    40. XM_047421109.1 → XP_047277065.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    41. XM_047421110.1 → XP_047277066.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    42. XM_047421113.1 → XP_047277069.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    43. XM_047421124.1 → XP_047277080.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    44. XM_047421129.1 → XP_047277085.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    45. XM_047421114.1 → XP_047277070.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    46. XM_047421115.1 → XP_047277071.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    47. XM_047421132.1 → XP_047277088.1  cyclin-D-binding Myb-like transcription factor 1 isoform X4

    48. XM_047421135.1 → XP_047277091.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      88402370..88446262
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359466.1 → XP_054215441.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    2. XM_054359456.1 → XP_054215431.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    3. XM_054359467.1 → XP_054215442.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    4. XM_054359469.1 → XP_054215444.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    5. XM_054359461.1 → XP_054215436.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    6. XM_054359479.1 → XP_054215454.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    7. XM_054359465.1 → XP_054215440.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    8. XM_054359494.1 → XP_054215469.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    9. XM_054359459.1 → XP_054215434.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    10. XM_054359489.1 → XP_054215464.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    11. XM_054359482.1 → XP_054215457.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    12. XM_054359498.1 → XP_054215473.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    13. XM_054359454.1 → XP_054215429.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    14. XM_054359490.1 → XP_054215465.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    15. XM_054359481.1 → XP_054215456.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    16. XM_054359500.1 → XP_054215475.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    17. XM_054359460.1 → XP_054215435.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    18. XM_054359492.1 → XP_054215467.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    19. XM_054359480.1 → XP_054215455.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    20. XM_054359485.1 → XP_054215460.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    21. XM_054359475.1 → XP_054215450.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    22. XM_054359497.1 → XP_054215472.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    23. XM_054359455.1 → XP_054215430.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    24. XM_054359464.1 → XP_054215439.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    25. XM_054359486.1 → XP_054215461.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    26. XM_054359458.1 → XP_054215433.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    27. XM_054359462.1 → XP_054215437.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    28. XM_054359470.1 → XP_054215445.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    29. XM_054359471.1 → XP_054215446.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    30. XM_054359472.1 → XP_054215447.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    31. XM_054359495.1 → XP_054215470.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    32. XM_054359473.1 → XP_054215448.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    33. XM_054359474.1 → XP_054215449.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    34. XM_054359493.1 → XP_054215468.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    35. XM_054359484.1 → XP_054215459.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    36. XM_054359457.1 → XP_054215432.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    37. XM_054359463.1 → XP_054215438.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    38. XM_054359488.1 → XP_054215463.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    39. XM_054359468.1 → XP_054215443.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      B2RBE1, B4DJS5, Q05C48, Q59G79, Q6IS13, Q969T2, Q9H2Z2, Q9H2Z3, Q9Y222

    40. XM_054359483.1 → XP_054215458.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    41. XM_054359477.1 → XP_054215452.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    42. XM_054359478.1 → XP_054215453.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    43. XM_054359487.1 → XP_054215462.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    44. XM_054359476.1 → XP_054215451.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    45. XM_054359491.1 → XP_054215466.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

    46. XM_054359499.1 → XP_054215474.1  cyclin-D-binding Myb-like transcription factor 1 isoform X5

    47. XM_054359502.1 → XP_054215477.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

    48. XM_054359496.1 → XP_054215471.1  cyclin-D-binding Myb-like transcription factor 1 isoform X4

    49. XM_054359501.1 → XP_054215476.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y222.1 GenPept UniProtKB/Swiss-Prot:Q9Y222

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