ARHGAP32 Rho GTPase activating protein 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ARHGAP32provided by HGNC
Official Full Name: Rho GTPase activating protein 32provided by HGNC
Primary source: HGNC:HGNC:17399
See related: Ensembl:ENSG00000134909 MIM:608541; AllianceGenome:HGNC:17399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
Summary: RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q24.3

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (128965060..129279632, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (128999975..129315124, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (128834955..129149413, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
Title: Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
Title: Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain
Title: p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation.
the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.
Title: The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.
The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
Title: The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits.
Title: PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.
miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity.
Title: An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling.
Title: PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.
Title: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
is phosphorylated by Fyn in oligodendrocytes
Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2896 (e-PCR)
- UniSTS:152066

RH103006 (e-PCR)
- UniSTS:97340

G27495 (e-PCR)
- UniSTS:6734

D11S2097 (e-PCR)
- UniSTS:84840

STS-M79191 (e-PCR)
- UniSTS:78959

SHGC-82118 (e-PCR)
- UniSTS:103040

D11S3120 (e-PCR)
- UniSTS:152213

D11S4354 (e-PCR)
- UniSTS:52132

WI-11842 (e-PCR)
- UniSTS:32192

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	TAS Traceable Author Statement more info
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in fibrillar center	IBA Inferred from Biological aspect of Ancestor more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: rho GTPase-activating protein 32

Names: GAB-associated CDC42; GAB-associated Cdc42/Rac GTPase-activating protein; GTPase regulator interacting with TrkA; GTPase-activating protein for Cdc42 and Rac1; RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling; brain-specific Rho GTP-ase-activating protein; brain-specific Rho GTPase-activating protein; rac GTPase activating protein; rho-type GTPase-activating protein 32; rho/Cdc42/Rac GTPase-activating protein RICS; rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142685.2 → NP_001136157.1 rho GTPase-activating protein 32 isoform 1

See identical proteins and their annotated locations for NP_001136157.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform (1). This isoform is also known as PX-RICS.

Source sequence(s)

AP000747, AP000751, AP002886

Consensus CDS

CCDS44769.1

UniProtKB/Swiss-Prot

A7KAX9, I7H0B0, O94820, Q86YL6, Q8IUG4, Q9BWG3

UniProtKB/TrEMBL

A0A2X0SFD0

Related

ENSP00000310561.8, ENST00000310343.13

Conserved Domains (3) summary

cd07298
Location:127 → 241

PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS

cd11835
Location:263 → 316

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:368 → 562

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
NM_001378024.1 → NP_001364953.1 rho GTPase-activating protein 32 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AP000747, AP000751, AP002886

Consensus CDS

CCDS91623.1

UniProtKB/TrEMBL

A0A2X0SFD0, A0A804HK06

Related

ENSP00000507720.1, ENST00000682385.1

Conserved Domains (3) summary

cd07298
Location:141 → 255

PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS

cd11835
Location:277 → 330

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:382 → 576

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
NM_001378025.1 → NP_001364954.1 rho GTPase-activating protein 32 isoform 4

Status: VALIDATED

Source sequence(s)

AP000747, AP000751, AP002886

UniProtKB/TrEMBL

A0A2X0SFD0

Conserved Domains (3) summary

cd07298
Location:87 → 201

PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS

cd11835
Location:223 → 276

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:328 → 522

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
NM_014715.4 → NP_055530.2 rho GTPase-activating protein 32 isoform 2

See identical proteins and their annotated locations for NP_055530.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.

Source sequence(s)

AB079856, AP000751, BQ319051, EF127492

Consensus CDS

CCDS31718.1

UniProtKB/TrEMBL

A0A2X0SFD0

Related

ENSP00000376425.3, ENST00000392657.7

Conserved Domains (1) summary

cd04384
Location:19 → 213

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

128965060..129279632 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047427929.1 → XP_047283885.1 rho GTPase-activating protein 32 isoform X4
XM_047427927.1 → XP_047283883.1 rho GTPase-activating protein 32 isoform X2
XM_047427926.1 → XP_047283882.1 rho GTPase-activating protein 32 isoform X2
XM_047427930.1 → XP_047283886.1 rho GTPase-activating protein 32 isoform X4
XM_017018595.3 → XP_016874084.1 rho GTPase-activating protein 32 isoform X2

UniProtKB/TrEMBL

A0A2X0SFD0

Conserved Domains (3) summary

cd07298
Location:101 → 215

PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS

cd11835
Location:237 → 290

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:342 → 536

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
XM_011543072.3 → XP_011541374.1 rho GTPase-activating protein 32 isoform X2

See identical proteins and their annotated locations for XP_011541374.1

UniProtKB/TrEMBL

A0A2X0SFD0

Conserved Domains (3) summary

cd07298
Location:101 → 215

PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS

cd11835
Location:237 → 290

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:342 → 536

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
XM_047427928.1 → XP_047283884.1 rho GTPase-activating protein 32 isoform X3
XM_011543073.3 → XP_011541375.2 rho GTPase-activating protein 32 isoform X1

UniProtKB/TrEMBL

A0A2X0SFD0
XM_017018596.2 → XP_016874085.1 rho GTPase-activating protein 32 isoform X7

UniProtKB/TrEMBL

A0A2X0SFD0
XM_011543075.3 → XP_011541377.1 rho GTPase-activating protein 32 isoform X5

UniProtKB/TrEMBL

A0A2X0SFD0

Conserved Domains (1) summary

cd04384
Location:43 → 237

RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
XM_017018597.3 → XP_016874086.1 rho GTPase-activating protein 32 isoform X6