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    Trim12a tripartite motif-containing 12A [ Mus musculus (house mouse) ]

    Gene ID: 76681, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Trim12aprovided by MGI
    Official Full Name
    tripartite motif-containing 12Aprovided by MGI
    Primary source
    MGI:MGI:1923931
    See related
    Ensembl:ENSMUSG00000066258 AllianceGenome:MGI:1923931
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trim12; 2310043C01Rik
    Summary
    Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in cytoplasm. Is expressed in bladder and testis. Orthologous to human TRIM5 (tripartite motif containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.6), thymus adult (RPKM 3.8) and 27 other tissues See more
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    Genomic context

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    Location:
    7 E3; 7 55.69 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (103949100..103964765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (104299893..104315558, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24846 Neighboring gene tripartite motif-containing 5 Neighboring gene predicted gene, 57517 Neighboring gene STARR-positive B cell enhancer ABC_E875 Neighboring gene STARR-positive B cell enhancer ABC_E2839 Neighboring gene STARR-positive B cell enhancer ABC_E6579 Neighboring gene STARR-positive B cell enhancer ABC_E2840 Neighboring gene STARR-positive B cell enhancer ABC_E876 Neighboring gene predicted gene 15133 Neighboring gene predicted gene, 17788 Neighboring gene tripartite motif-containing 34B Neighboring gene tripartite motif-containing 12C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Copy number variation influences gene expression and metabolic traits in mice. Orozco LD, et al. Hum Mol Genet, 2009 Nov 1. PMID 19648292, Free PMC Article
    2. Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk. Blackburn AC, et al. Am J Pathol, 2007 Jun. PMID 17525270, Free PMC Article
    3. An expanded clade of rodent Trim5 genes. Tareen SU, et al. Virology, 2009 Mar 15. PMID 19147168, Free PMC Article
    4. Postnatal gene expression in the normal mouse cornea by SAGE. Norman B, et al. Invest Ophthalmol Vis Sci, 2004 Feb. PMID 14744882
    5. Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. Boon AC, et al. J Virol, 2009 Oct. PMID 19706712, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with omegasome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 12A
    Names
    tripartite motif protein 12
    tripartite motif-containing 12
    tripartite motif-containing protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368753.1 → NP_001355682.1  tripartite motif-containing protein 12A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC142110
      UniProtKB/TrEMBL
      Q504P5
      Conserved Domains (3) summary
      pfam08317
      Location:132 → 209
      Spc7; Spc7 kinetochore protein
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001368754.1 → NP_001355683.1  tripartite motif-containing protein 12A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC142110
      Consensus CDS
      CCDS90296.1
      UniProtKB/Swiss-Prot
      Q99PQ1, Q9D704
      Related
      ENSMUSP00000065008.7, ENSMUST00000070943.7
      Conserved Domains (4) summary
      smart00336
      Location:96 → 132
      BBOX; B-Box-type zinc finger
      COG5432
      Location:6 → 112
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      pfam07888
      Location:128 → 251
      CALCOCO1; Calcium binding and coiled-coil domain (CALCOCO1) like
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_023835.2 → NP_076324.2  tripartite motif-containing protein 12A isoform 2

      See identical proteins and their annotated locations for NP_076324.2

      Status: VALIDATED

      Source sequence(s)
      AC142110, AK009769, DV553257
      Consensus CDS
      CCDS40067.1
      UniProtKB/TrEMBL
      A0A0R4J1B5
      Related
      ENSMUSP00000102452.3, ENSMUST00000106839.9
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      103949100..103964765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312375.3 → XP_017167864.1  tripartite motif-containing protein 12A isoform X2

      UniProtKB/TrEMBL
      D3YVI1
      Related
      ENSMUSP00000102450.2, ENSMUST00000106837.8
      Conserved Domains (3) summary
      cd00162
      Location:15 → 58
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_030243083.2 → XP_030098943.1  tripartite motif-containing protein 12A isoform X3

      UniProtKB/TrEMBL
      Q504P5
      Conserved Domains (3) summary
      pfam08317
      Location:132 → 209
      Spc7; Spc7 kinetochore protein
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_030243081.2 → XP_030098941.1  tripartite motif-containing protein 12A isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1B5
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_017312372.3 → XP_017167861.1  tripartite motif-containing protein 12A isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1B5
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    5. XM_030243080.2 → XP_030098940.1  tripartite motif-containing protein 12A isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1B5
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_017312373.3 → XP_017167862.1  tripartite motif-containing protein 12A isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1B5
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    7. XM_030243082.2 → XP_030098942.1  tripartite motif-containing protein 12A isoform X1

      UniProtKB/TrEMBL
      A0A0R4J1B5
      Conserved Domains (3) summary
      COG4372
      Location:119 → 297
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      cd19761
      Location:96 → 133
      Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
      cl17238
      Location:12 → 60
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99PQ1.1 GenPept UniProtKB/Swiss-Prot:Q99PQ1

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