Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4a14provided by MGI
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 14provided by MGI
Primary source: MGI:MGI:1096550
See related: Ensembl:ENSMUSG00000028715 AllianceGenome:MGI:1096550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable 16-hydroxypalmitate dehydrogenase activity; arachidonic acid binding activity; and monooxygenase activity. Predicted to be involved in fatty acid metabolic process; icosanoid biosynthetic process; and kidney development. Predicted to be located in apical plasma membrane; cytoplasm; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 119.3), liver E18 (RPKM 97.4) and 1 other tissue See more
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Genomic context

Location:: 4 D1; 4 53.04 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115343397..115353355, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115486200..115496158, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.
Title: H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.
CYP4A14 may represent a useful target for the treatment of AngII-associated renal damage.
Title: Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice.
this study provides a link between CYP4A14 and NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, HFD- and MCD-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced NASH.
Title: Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis.
Hypertension in Cyp4a14(-/-) male mice was accompanied by decreased renal perfusion and reduced glomerular filtration rates
Title: The Blood Pressure-Lowering Effect of 20-HETE Blockade in Cyp4a14(-/-) Mice Is Associated with Natriuresis.
These results implicate Cyp4a10 and Cyp4a14 in the regulation of the host inflammatory response to enteropathogenic bacterial infection but not to acute aseptic inflammation.
Title: Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.
DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
Title: Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
Deletion of the Cyp4a gene conferred a prohypertensive status via increased 20-HETE synthesis and eNOS uncoupling leading to increased oxidative stress, enhanced vasoconstriction but diminished vasodilation as well as a defect in renal excretory capacity.
Title: Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.
Hypertension in the Cyp4a14 knockout mice appears to be driven by excessive fluid reabsorption in the proximal tubule, which is secondary to overexpression of NHE3.
Title: Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice.
Drug metabolizing enzyme induction of Cyp4a14 is reported in experimental fatty liver.
Title: Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis.
Perfluorocarboxylic acids induce Cyp2b10/Cyp4a14 in mouse liver through activation of PPAR-alpha and CAR transcription factors.
Title: Perfluorocarboxylic acids induce cytochrome P450 enzymes in mouse liver through activation of PPAR-alpha and CAR transcription factors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

AI314743 (e-PCR)
- UniSTS:179049

Cyp4a14 (e-PCR), detects polymorphism
- UniSTS:463007

Cyp4a14 (e-PCR), detects polymorphism
- UniSTS:546726

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 16-hydroxypalmitate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid binding	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonic acid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4A14

Names: CYPIVA14; cytochrome P450, 4a14; cytochrome P450-LA-omega 3; lauric acid hydroxylase; lauric acid omega-hydroxylase 3; long-chain fatty acid omega-monooxygenase

NP_031848.1

EC 1.14.14.80

XP_006502787.2

EC 1.14.14.80

XP_017175435.1

EC 1.14.14.80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007822.2 → NP_031848.1 cytochrome P450 4A14

See identical proteins and their annotated locations for NP_031848.1

Status: VALIDATED

Source sequence(s)

AK165452, BC089609, BF322553

Consensus CDS

CCDS18491.1

UniProtKB/Swiss-Prot

A2A975, O35728, Q3UER2, Q5EBH0

Related

ENSMUSP00000030487.3, ENSMUST00000030487.3

Conserved Domains (1) summary

pfam00067
Location:52 → 501

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

115343397..115353355 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502724.3 → XP_006502787.2 cytochrome P450 4A14 isoform X2

Conserved Domains (1) summary

pfam00067
Location:52 → 421

p450; Cytochrome P450
XM_017319946.2 → XP_017175435.1 cytochrome P450 4A14 isoform X1

Conserved Domains (1) summary

pfam00067
Location:52 → 452

p450; Cytochrome P450