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    Il1rl2 interleukin 1 receptor-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 107527, updated on 12-May-2024

    Summary

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    Official Symbol
    Il1rl2provided by MGI
    Official Full Name
    interleukin 1 receptor-like 2provided by MGI
    Primary source
    MGI:MGI:1913107
    See related
    Ensembl:ENSMUSG00000070942 AllianceGenome:MGI:1913107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-1Rrp2
    Summary
    Predicted to enable cytokine receptor activity. Acts upstream of or within positive regulation of T cell differentiation; positive regulation of interleukin-6 production; and regulation of inflammatory response. Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human IL1RL2 (interleukin 1 receptor like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in mammary gland adult (RPKM 3.8), subcutaneous fat pad adult (RPKM 2.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Il1rl2 in Genome Data Viewer
    Location:
    1 B; 1 18.96 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40363697..40406722)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40324589..40367555)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35741 Neighboring gene interleukin 1 receptor, type I Neighboring gene STARR-positive B cell enhancer ABC_E5749 Neighboring gene STARR-seq mESC enhancer starr_00738 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis. Goldstein JD, et al. Life Sci Alliance, 2020 Jun. PMID 32345660, Free PMC Article
    2. Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines. Nishikawa H, et al. Kidney Int, 2018 Mar. PMID 29241623
    3. Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts. Schmitt V, et al. Eur J Immunol, 2017 Dec. PMID 28857172
    4. IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia. Aoyagi T, et al. Mucosal Immunol, 2017 Jul. PMID 27966554, Free PMC Article
    5. Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage. Medina-Contreras O, et al. J Immunol, 2016 Jan 1. PMID 26590314, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
      Title: Interleukin-38 promotes skin tumorigenesis in an IL-1Rrp2-dependent manner.
    2. IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
      Title: IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis.
    3. IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
      Title: IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria.
    4. IL-36R likely contributes to acute kidney injury pathogenesis through NF-kB activity and IL-6 and TNF-a upregulation.
      Title: Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines.
    5. these findings reveal a fundamental contribution for the IL-36/IL-36R axis in regulating the Treg-Th9 cell balance with broad implications for Th cell-mediated disorders, such as inflammatory bowel diseases and particularly ulcerative colitis
      Title: IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
    6. IL-36R-deficient mice were protected from influenza virus-induced lung injury and mortality
      Title: IL-36 receptor deletion attenuates lung injury and decreases mortality in murine influenza pneumonia.
    7. Data show that Interleukin-36 receptor (IL-36R)-deficient fibroblast-like synoviocytes (FLS) had a limited capacity to support plasma cells (PC) survival compared to wild-type FLS.
      Title: Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1, type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-like 2
    Names
    IL-36 receptor
    IL1R-rp2
    interleukin-1 receptor related protein 2
    NP_001343407.1
    NP_573456.1
    XP_006495672.1
    XP_006495673.1
    XP_036021840.1
    XP_036021873.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356478.1 → NP_001343407.1  interleukin-1 receptor-like 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC167168
      Consensus CDS
      CCDS14910.1
      UniProtKB/Swiss-Prot
      Q9ERS7
      UniProtKB/TrEMBL
      Q149G7
      Related
      ENSMUSP00000142248.2, ENSMUST00000194296.6
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 115
      Ig; Immunoglobulin domain

    2. NM_133193.4 → NP_573456.1  interleukin-1 receptor-like 2 precursor

      See identical proteins and their annotated locations for NP_573456.1

      Status: VALIDATED

      Source sequence(s)
      AC167168
      Consensus CDS
      CCDS14910.1
      UniProtKB/Swiss-Prot
      Q9ERS7
      UniProtKB/TrEMBL
      Q149G7
      Related
      ENSMUSP00000092630.4, ENSMUST00000095020.9
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 115
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40363697..40406722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165947.1 → XP_036021840.1  interleukin-1 receptor-like 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9ERS7
      UniProtKB/TrEMBL
      Q149G7
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 115
      Ig; Immunoglobulin domain

    2. XM_006495609.4 → XP_006495672.1  interleukin-1 receptor-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006495672.1

      UniProtKB/Swiss-Prot
      Q9ERS7
      UniProtKB/TrEMBL
      Q149G7
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 115
      Ig; Immunoglobulin domain

    3. XM_006495610.5 → XP_006495673.1  interleukin-1 receptor-like 2 isoform X1

      See identical proteins and their annotated locations for XP_006495673.1

      UniProtKB/Swiss-Prot
      Q9ERS7
      UniProtKB/TrEMBL
      Q149G7
      Conserved Domains (3) summary
      pfam01582
      Location:389 → 539
      TIR; TIR domain
      cd00096
      Location:31 → 35
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:25 → 115
      Ig; Immunoglobulin domain

    4. XM_036165980.1 → XP_036021873.1  interleukin-1 receptor-like 2 isoform X2

      Conserved Domains (3) summary
      pfam01582
      Location:361 → 511
      TIR; TIR domain
      cd00096
      Location:3 → 7
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:1 → 87
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERS7.1 GenPept UniProtKB/Swiss-Prot:Q9ERS7

    Gene LinkOut

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