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    Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 66435, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Uggt2provided by MGI
    Official Full Name
    UDP-glucose glycoprotein glucosyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1913685
    See related
    Ensembl:ENSMUSG00000042104 AllianceGenome:MGI:1913685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ugcgl2; 1810064L21Rik; 3110001A05Rik; 3110027P15Rik; A230065J02Rik
    Summary
    Predicted to enable UDP-glucose:glycoprotein glucosyltransferase activity and unfolded protein binding activity. Predicted to be involved in ER-associated misfolded protein catabolic process and protein N-linked glycosylation via asparagine. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum. Orthologous to human UGGT2 (UDP-glucose glycoprotein glucosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 4.9), CNS E14 (RPKM 4.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E4; 14 62.61 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119219177..119337208, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118982006..119099796, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4125 Neighboring gene DAZ interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119381910-119382076 Neighboring gene STARR-positive B cell enhancer mm9_chr14:119406665-119406966 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene predicted gene, 16835 Neighboring gene STARR-seq mESC enhancer starr_37667 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene STARR-seq mESC enhancer starr_37668 Neighboring gene STARR-seq mESC enhancer starr_37669 Neighboring gene STARR-seq mESC enhancer starr_37670 Neighboring gene STARR-seq mESC enhancer starr_37671 Neighboring gene tera pseudogene Neighboring gene CD24a antigen pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress. Hung HH, et al. Proc Natl Acad Sci U S A, 2022 Dec 20. PMID 36508673, Free PMC Article
    2. Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT). Prados MB, et al. Biochim Biophys Acta, 2013 Dec. PMID 24140206
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.
      Title: Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress.
    2. the expression of two UGGT isoforms, UGGT1 and UGGT2 was demonstrated and both isoforms are active mouse hybridoma cells.
      Title: Progesterone regulates the expression and activity of two mouse isoforms of the glycoprotein folding sensor UDP-Glc: glycoprotein glucosyltransferase (UGGT).
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose:glycoprotein glucosyltransferase 2
    Names
    UDP-glucose ceramide glucosyltransferase-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081252.2 → NP_001074721.2  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_001074721.2

      Status: VALIDATED

      Source sequence(s)
      AC154760
      Consensus CDS
      CCDS37013.2
      UniProtKB/TrEMBL
      E9Q4X2
      Related
      ENSMUSP00000121249.2, ENSMUST00000156203.8
      Conserved Domains (2) summary
      cd06432
      Location:1219 → 1466
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:24 → 1181
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      119219177..119337208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519376.3 → XP_006519439.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

      Conserved Domains (6) summary
      pfam06427
      Location:1083 → 1189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
      pfam18400
      Location:36 → 217
      Thioredoxin_12; Thioredoxin-like domain
      pfam18401
      Location:287 → 394
      Thioredoxin_13; Thioredoxin-like domain
      pfam18402
      Location:428 → 676
      Thioredoxin_14; Thioredoxin-like domain
      pfam18403
      Location:700 → 922
      Thioredoxin_15; Thioredoxin-like domain
      pfam18404
      Location:1219 → 1417
      Glyco_transf_24; Glucosyltransferase 24

    2. XM_006519380.5 → XP_006519443.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

      See identical proteins and their annotated locations for XP_006519443.1

      Conserved Domains (6) summary
      pfam06427
      Location:1083 → 1189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
      pfam18400
      Location:36 → 217
      Thioredoxin_12; Thioredoxin-like domain
      pfam18401
      Location:287 → 394
      Thioredoxin_13; Thioredoxin-like domain
      pfam18402
      Location:428 → 676
      Thioredoxin_14; Thioredoxin-like domain
      pfam18403
      Location:700 → 922
      Thioredoxin_15; Thioredoxin-like domain
      pfam18404
      Location:1219 → 1235
      Glyco_transf_24; Glucosyltransferase 24

    RNA

    1. XR_004938436.1 RNA Sequence

    2. XR_003950882.1 RNA Sequence

    3. XR_003950881.1 RNA Sequence

    4. XR_001781137.2 RNA Sequence

    5. XR_004938425.1 RNA Sequence

    6. XR_004938427.1 RNA Sequence

    7. XR_004938428.1 RNA Sequence

    8. XR_003950883.1 RNA Sequence

    9. XR_004938431.1 RNA Sequence

    10. XR_003950885.1 RNA Sequence

    11. XR_004938430.1 RNA Sequence

    12. XR_004938433.1 RNA Sequence

    13. XR_004938434.1 RNA Sequence

    14. XR_004938435.1 RNA Sequence

    15. XR_003950884.1 RNA Sequence

    16. XR_003950888.1 RNA Sequence

    17. XR_003950889.1 RNA Sequence

    18. XR_004938429.1 RNA Sequence

    19. XR_003950887.1 RNA Sequence

    20. XR_004938438.1 RNA Sequence

    21. XR_004938439.1 RNA Sequence

    22. XR_003950891.2 RNA Sequence

    23. XR_003950890.1 RNA Sequence

    24. XR_003950892.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025561.1: Suppressed sequence

      Description
      NM_025561.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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