Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gabra3provided by MGI
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha 3provided by MGI
Primary source: MGI:MGI:95615
See related: Ensembl:ENSMUSG00000031343 AllianceGenome:MGI:95615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gabra-3
Summary: Enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within ion transport. Located in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 17.8), cortex adult (RPKM 14.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.24 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (71476282..71700525, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (72432676..72656919, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alpha3 subunit expression in late adulthood (18months old) is accompanied by an increase in the expression of inflammatory markers within the mouse colon. Knockout mouse studies show that the GABAAR alpha3 subunit plays a role in mediating the colonic inflammation associated with the process of ageing.
Title: Developmental and age-dependent plasticity of GABA(A) receptors in the mouse colon: Implications in colonic motility and inflammation.
Absence of the Gabra3 receptor subunit slows recovery from ethanol-induced incoordination.
Title: Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.
alpha3 subunit containing GABA(A) receptors as key mediators of the reward-related effects of benzodiazepines
Title: Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward.
Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice
Title: Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice.
Resutls show that the variation in editing gave receptors like HTR2C and GABA(A) (gamma-aminobutyric acid type A) a different set of protein isoforms during development from those in the adult animal.
Title: Large-scale mRNA sequencing determines global regulation of RNA editing during brain development.
Deletion of the GABAAR alpha3 subunit reduces evoked thalamic oscillatory activity.
Title: A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures.
The phenotypes following global deletion of the GABAA receptor alpha3 subunit provided relevant insights into the potential behavioural relevance of this specific receptor subtypes in the modulation of both affective and cognitive functions.
Title: Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors.
lack of alpha3-GABA(A) receptors is extensively compensated for to preserve the integrity of thalamo-cortical function in physiological and pathophysiological situations
Title: Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice.
The alpha3 subunit mRNAs first appeared in the differentiating zone at embryonic day 13 (E13). And localized in the developing Purkinje cells and cerebellar nucleus neurons, and disappeared from Purkinje cells by the end of first postnatal week.
Title: Transient expression of GABAA receptor alpha2 and alpha3 subunits in differentiating cerebellar neurons.
editing of the Gabra-3 mRNA is important for normal brain development.The extent of editing is low at birth but increases with age, reaching close to 100% in the adult brain.
Title: Editing modifies the GABA(A) receptor subunit alpha3.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

DXMit210 (e-PCR), detects polymorphism
- UniSTS:132099

Gabra3 (e-PCR), detects polymorphism
- UniSTS:525649

px-59b3 (e-PCR)
- UniSTS:258428

Gabra3 (e-PCR), detects polymorphism
- UniSTS:496043

px-40d5 (e-PCR)
- UniSTS:257746

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
part_of transmembrane transporter complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit alpha-3

Names: GABA(A) receptor subunit alpha-3; gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357814.1 → NP_001344743.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL731695, BX119994

Consensus CDS

CCDS30187.1

UniProtKB/Swiss-Prot

P26049

UniProtKB/TrEMBL

Q8CAB3

Related

ENSMUSP00000110201.3, ENSMUST00000114554.3

Conserved Domains (2) summary

TIGR00860
Location:69 → 478

LIC; Cation transporter family protein

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
NM_001357815.1 → NP_001344744.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL731695, BX119994

UniProtKB/TrEMBL

Q8CAB3

Conserved Domains (1) summary

cl27321
Location:83 → 492

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
NM_001357816.1 → NP_001344745.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 3

Status: VALIDATED

Source sequence(s)

AL731695, BX119994

UniProtKB/TrEMBL

B1AVY2

Conserved Domains (1) summary

cl27321
Location:100 → 509

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
NM_001358103.1 → NP_001345032.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL731695, BX119994

Consensus CDS

CCDS30187.1

UniProtKB/Swiss-Prot

P26049

UniProtKB/TrEMBL

Q8CAB3

Conserved Domains (2) summary

TIGR00860
Location:69 → 478

LIC; Cation transporter family protein

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
NM_008067.4 → NP_032093.3 gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

See identical proteins and their annotated locations for NP_032093.3

Status: VALIDATED

Source sequence(s)

AK039144, AK134760, AL731695, BX119994, CD354278

Consensus CDS

CCDS30187.1

UniProtKB/Swiss-Prot

P26049

UniProtKB/TrEMBL

Q8CAB3

Related

ENSMUSP00000062638.7, ENSMUST00000055966.13

Conserved Domains (2) summary

TIGR00860
Location:69 → 478

LIC; Cation transporter family protein

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

71476282..71700525 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161818.1 → XP_036017711.1 gamma-aminobutyric acid receptor subunit alpha-3 isoform X1

UniProtKB/Swiss-Prot

P26049

UniProtKB/TrEMBL

Q8CAB3

Conserved Domains (2) summary

TIGR00860
Location:69 → 478

LIC; Cation transporter family protein

cd19036
Location:75 → 274

LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)