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    Dpy19l1 dpy-19 like C-mannosyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 244745, updated on 4-May-2024

    Summary

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    Official Symbol
    Dpy19l1provided by MGI
    Official Full Name
    dpy-19 like C-mannosyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1915685
    See related
    Ensembl:ENSMUSG00000043067 AllianceGenome:MGI:1915685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030402K12; 1100001I19Rik
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be involved in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear inner membrane. Is expressed in brain; lung; metanephros; and sensory organ. Orthologous to human DPY19L1 (dpy-19 like C-mannosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 16.6), cortex adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dpy19l1 in Genome Data Viewer
    Location:
    9 A4; 9 10.15 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (24323074..24414436, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (24411778..24503140, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23579 Neighboring gene neuropeptide S receptor 1 Neighboring gene STARR-seq mESC enhancer starr_23580 Neighboring gene STARR-seq mESC enhancer starr_23583 Neighboring gene predicted gene 10701 Neighboring gene predicted gene, 22380 Neighboring gene predicted gene, 57533 Neighboring gene STARR-seq mESC enhancer starr_23585 Neighboring gene dpy-19 like 2 Neighboring gene STARR-seq mESC enhancer starr_23586 Neighboring gene cysteine-rich perinuclear theca 4 Neighboring gene STARR-seq mESC enhancer starr_23587 Neighboring gene STARR-seq mESC enhancer starr_23588 Neighboring gene T-box 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth. Watanabe K, et al. PLoS One, 2016. PMID 27959946, Free PMC Article
    2. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Shcherbakova A, et al. Proc Natl Acad Sci U S A, 2017 Mar 7. PMID 28202721, Free PMC Article
    3. Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex. Watanabe K, et al. Development, 2011 Nov. PMID 22028030, Free PMC Article
    4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions.
      Title: Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3.
    2. Dpy19L1 is localized to the ER membrane and regulates neurite extension during development.
      Title: Endoplasmic Reticulum-Localized Transmembrane Protein Dpy19L1 Is Required for Neurite Outgrowth.
    3. Dpy19l1 is required for the proper radial migration of glutamatergic neurons, an evolutionarily conserved role for the Dpy19 family in neuronal migration.
      Title: Dpy19l1, a multi-transmembrane protein, regulates the radial migration of glutamatergic neurons in the developing cerebral cortex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein C-mannosyl-transferase DPY19L1
    Names
    dpy-19-like 1
    dpy-19-like protein 1
    probable C-mannosyltransferase DPY19L1
    protein dpy-19 homolog 1
    NP_001346877.1
    NP_766508.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359948.1 → NP_001346877.1  protein C-mannosyl-transferase DPY19L1

      Status: VALIDATED

      Source sequence(s)
      AC102554, BU757480, CT010514
      Consensus CDS
      CCDS22931.2
      UniProtKB/Swiss-Prot
      A6X919, Q3UP31, Q8CD79
      Related
      ENSMUSP00000119986.2, ENSMUST00000142064.8
      Conserved Domains (2) summary
      pfam10034
      Location:105 → 742
      Dpy19; Q-cell neuroblast polarisation
      cl28033
      Location:11 → 91
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    2. NM_172920.4 → NP_766508.3  protein C-mannosyl-transferase DPY19L1

      See identical proteins and their annotated locations for NP_766508.3

      Status: VALIDATED

      Source sequence(s)
      AK143845, BU757480, CD352443, CT010514
      Consensus CDS
      CCDS22931.2
      UniProtKB/Swiss-Prot
      A6X919, Q3UP31, Q8CD79
      Related
      ENSMUSP00000129575.2, ENSMUST00000170356.2
      Conserved Domains (2) summary
      pfam10034
      Location:105 → 742
      Dpy19; Q-cell neuroblast polarisation
      cl28033
      Location:11 → 91
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      24323074..24414436 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6X919.1 GenPept UniProtKB/Swiss-Prot:A6X919

    Gene LinkOut

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