Metap1 methionyl aminopeptidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Metap1provided by MGI
Official Full Name: methionyl aminopeptidase 1provided by MGI
Primary source: MGI:MGI:1922874
See related: Ensembl:ENSMUSG00000005813 AllianceGenome:MGI:1922874
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0094; 1700029C17Rik
Summary: Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 27.6), CNS E11.5 (RPKM 21.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G3; 3 64.27 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (138164721..138195143, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138458960..138489382, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.
Title: Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW047992 (e-PCR)
- UniSTS:164227

NoName (e-PCR)
- UniSTS:493292

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables initiator methionyl aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methionine aminopeptidase 1

Names: MAP 1; Putative methionine aminopeptidase 1 (MetAP 1) (Peptidase M 1); metAP 1; peptidase M 1

NP_780433.1

EC 3.4.11.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175224.4 → NP_780433.1 methionine aminopeptidase 1

See identical proteins and their annotated locations for NP_780433.1

Status: PROVISIONAL

Source sequence(s)

AC079845

Consensus CDS

CCDS17869.1

UniProtKB/Swiss-Prot

Q8BP48

UniProtKB/TrEMBL

Q4VAA9

Related

ENSMUSP00000029804.9, ENSMUST00000029804.13

Conserved Domains (1) summary

cl00279
Location:14 → 382

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...