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    Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 [ Mus musculus (house mouse) ]

    Gene ID: 74519, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Cyp2j9provided by MGI
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 9provided by MGI
    Primary source
    MGI:MGI:1921769
    See related
    Ensembl:ENSMUSG00000015224 AllianceGenome:MGI:1921769
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8430417E17Rik
    Summary
    Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Predicted to be involved in epoxygenase P450 pathway; linoleic acid metabolic process; and xenobiotic metabolic process. Located in endoplasmic reticulum. Is expressed in alimentary system; ductus arteriosus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 8.9), cortex adult (RPKM 7.7) and 20 other tissues See more
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    Genomic context

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    See Cyp2j9 in Genome Data Viewer
    Location:
    4 C5; 4 44.66 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (96456661..96480748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (96568424..96592523, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10825 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 8 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 6 Neighboring gene STARR-seq mESC enhancer starr_10826 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 5 Neighboring gene predicted gene 12695

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain. Qu W, et al. J Biol Chem, 2001 Jul 6. PMID 11328810
    2. EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid. Baragatti B, et al. Am J Physiol Heart Circ Physiol, 2009 Dec. PMID 19801493, Free PMC Article
    3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141274

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonic acid 11,12-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid 14,15-epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables arachidonic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables linoleic acid epoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in epoxygenase P450 pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in icosanoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily j, polypeptide 9
    Names
    cytochrome P450, 2j9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419233.1 → NP_001406162.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683816
      Related
      ENSMUST00000126509.2

    2. NM_001419234.1 → NP_001406163.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL683816

    3. NM_001419236.1 → NP_001406165.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683816

    4. NM_028979.3 → NP_083255.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform 1

      See identical proteins and their annotated locations for NP_083255.1

      Status: VALIDATED

      Source sequence(s)
      AL683816
      Consensus CDS
      CCDS18370.1
      UniProtKB/TrEMBL
      Q924D1, Q9CRQ9
      Related
      ENSMUSP00000050464.9, ENSMUST00000055693.9
      Conserved Domains (1) summary
      pfam00067
      Location:44 → 497
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      96456661..96480748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253853.2 → XP_030109713.1  cytochrome P450, family 2, subfamily j, polypeptide 9 isoform X1

      UniProtKB/TrEMBL
      Q9CRQ9
      Conserved Domains (1) summary
      pfam00067
      Location:32 → 440
      p450; Cytochrome P450
    Nucleotide Protein Strain
    Heading Accession and Version

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