Sycp3 synaptonemal complex protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sycp3provided by MGI
Official Full Name: synaptonemal complex protein 3provided by MGI
Primary source: MGI:MGI:109542
See related: Ensembl:ENSMUSG00000020059 AllianceGenome:MGI:109542
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cor1; Scp3
Summary: Predicted to enable DNA binding activity. Involved in meiotic chromosome segregation and spermatogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; meiosis I cell cycle process; and sperm chromatin condensation. Located in condensed chromosome and male germ cell nucleus. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and primordial germ cell. Used to study azoospermia. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 5.3), kidney adult (RPKM 2.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 43.94 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (88295449..88309098)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88459587..88473236)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes.
Title: Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes.
Unlike other vertebrates, rat and mouse SYCP3 exists in 2 isoforms; the short isoform is conserved in vertebrates and the longer isoform, appeared 15 million years ago in a common ancestor of rat and mouse and after separation from the hamster branch.
Title: Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution.
X-linked lymphocyte-regulated protein pM1 (XMR), XLR, and SCP3 render tumor cells resistant to antitumor immunity
Title: Ectopic expression of X-linked lymphocyte-regulated protein pM1 renders tumor cells resistant to antitumor immunity.
The SYCP3 is expressed in germ cell-like cells. The nuclear distribution of SYCP3 in the germ cell-like cells is highly abnormal and not associated with the chromosomes of these cells.
Title: Mouse embryonic stem cells form follicle-like ovarian structures but do not progress through meiosis.
In Scp3-deficient (knockout) mice, spermatogenesis and testicular degeneration are augmented when E2F1 is also deficient.
Title: E2F1 deficiency impairs murine spermatogenesis and augments testicular degeneration in SCP3-nullizygous mice.
SYCP3 has a temporally restricted role in maintaining, but not establishing, cohesin-core organization during prophase I.
Title: SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division.
Rad21, and the superimposed SCP3 and SCP2, are involved in the monopolar attachment of sister kinetochores during meiosis I
Title: Involvement of the cohesin Rad21 and SCP3 in monopolar attachment of sister kinetochores during mouse meiosis I.
absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation
Title: Female germ cell aneuploidy and embryo death in mice lacking the meiosis-specific protein SCP3.
SYCP2 and SYCP3 proteins function in the specificity of chromatin attachment to the chromosome core
Title: Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment.
DNA double-stranded breaks are inefficiently repaired in Sycp3(-)(/)(-) oocytes, thereby generating a temporal spectrum of recombination errors. T
Title: Structural damage to meiotic chromosomes impairs DNA recombination and checkpoint control in mammalian oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mScp3 (e-PCR)
- UniSTS:514592

Sycp3 (e-PCR), detects polymorphism
- UniSTS:461899

G65198 (e-PCR)
- UniSTS:225879

Y08485 (e-PCR)
- UniSTS:180098

Sycp3 (e-PCR), detects polymorphism
- UniSTS:471180

Sycp3 (e-PCR), detects polymorphism
- UniSTS:497294

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in chiasma assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chiasma assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female meiosis chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in female meiosis chromosome separation	NAS Non-traceable Author Statement more info	PubMed
involved_in female meiosis sister chromatid cohesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral element assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic DNA repair synthesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sperm DNA condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sperm DNA condensation	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptonemal complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in synaptonemal complex	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptonemal complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in transverse filament	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synaptonemal complex protein 3

Names: SCP-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.