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    Fstl4 follistatin-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 320027, updated on 12-May-2024

    Summary

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    Official Symbol
    Fstl4provided by MGI
    Official Full Name
    follistatin-like 4provided by MGI
    Primary source
    MGI:MGI:2443199
    See related
    Ensembl:ENSMUSG00000036264 AllianceGenome:MGI:2443199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPIG1; mKIAA1061; B230374F23Rik
    Summary
    Enables brain-derived neurotrophic factor binding activity. Acts upstream of or within negative regulation of brain-derived neurotrophic factor receptor signaling pathway; negative regulation of collateral sprouting; and negative regulation of dendritic spine development. Located in secretory granule. Is expressed in medulla oblongata basal plate mantle layer; neural retina; olfactory cortex mantle layer; pons mantle layer; and telencephalon mantle layer. Orthologous to human FSTL4 (follistatin like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 3.4), cortex adult (RPKM 3.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fstl4 in Genome Data Viewer
    Location:
    11 B1.3; 11 31.86 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (52655320..53083277)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (52764489..53192450)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29466 Neighboring gene predicted gene, 30366 Neighboring gene STARR-seq mESC enhancer starr_29468 Neighboring gene predicted gene, 39823 Neighboring gene VISTA enhancer mm1724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52800603-52800790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52942269-52942487 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:52946269-52946452 Neighboring gene predicted gene 11186 Neighboring gene STARR-seq mESC enhancer starr_29473 Neighboring gene STARR-seq mESC enhancer starr_29474 Neighboring gene TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_29475 Neighboring gene STARR-seq mESC enhancer starr_29476 Neighboring gene STARR-positive B cell enhancer ABC_E2987 Neighboring gene heat shock protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4). Suzuki R, et al. Neurobiol Learn Mem, 2018 Jul. PMID 29783061
    2. Identification of retinal ganglion cells and their projections involved in central transmission of information about upward and downward image motion. Yonehara K, et al. PLoS One, 2009. PMID 19177171, Free PMC Article
    3. Expression of SPIG1 reveals development of a retinal ganglion cell subtype projecting to the medial terminal nucleus in the mouse. Yonehara K, et al. PLoS One, 2008 Feb 6. PMID 18253481, Free PMC Article
    4. Receptive Field Sizes of Nyx(nob) Mouse Retinal Ganglion Cells. Hölzel MB, et al. Int J Mol Sci, 2022 Mar 16. PMID 35328623, Free PMC Article
    5. Nystagmus in patients with congenital stationary night blindness (CSNB) originates from synchronously firing retinal ganglion cells. Winkelman BHJ, et al. PLoS Biol, 2019 Sep. PMID 31513577, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study showed enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4).
      Title: Enhanced extinction of aversive memories in mice lacking SPARC-related protein containing immunoglobulin domains 1 (SPIG1/FSTL4).
    2. This study demonistrated that SPIG1 negatively regulates BDNF maturation.
      Title: SPIG1 negatively regulates BDNF maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1061

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables brain-derived neurotrophic factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT acts_upstream_of_or_within negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of brain-derived neurotrophic factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of collateral sprouting IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of collateral sprouting IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    follistatin-related protein 4
    Names
    follistatin-like protein 4
    m-D/Bsp120I 1-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177059.4 → NP_796033.2  follistatin-related protein 4 precursor

      See identical proteins and their annotated locations for NP_796033.2

      Status: VALIDATED

      Source sequence(s)
      AL596382, AL604002, AL662836, AL662855
      Consensus CDS
      CCDS24673.1
      UniProtKB/Swiss-Prot
      A2RT35, Q5DU03, Q5STE3
      Related
      ENSMUSP00000042007.8, ENSMUST00000036796.8
      Conserved Domains (7) summary
      cd00096
      Location:266 → 322
      Ig; Immunoglobulin domain
      cd05736
      Location:357 → 432
      Ig2_Follistatin_like; Second immunoglobulin (Ig)-like domain of a follistatin-like molecule encoded by the Mahya gene and similar proteins
      smart00410
      Location:255 → 322
      IG_like; Immunoglobulin like
      cd00104
      Location:92 → 132
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
      pfam07679
      Location:340 → 429
      I-set; Immunoglobulin I-set domain
      pfam13499
      Location:178 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:178 → 242
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      52655320..53083277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533539.5 → XP_006533602.1  follistatin-related protein 4 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:1 → 55
      Ig; Immunoglobulin domain

    RNA

    1. XR_388477.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5STE3.1 GenPept UniProtKB/Swiss-Prot:Q5STE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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