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    Lmln leishmanolysin-like (metallopeptidase M8 family) [ Mus musculus (house mouse) ]

    Gene ID: 239833, updated on 12-May-2024

    Summary

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    Official Symbol
    Lmlnprovided by MGI
    Official Full Name
    leishmanolysin-like (metallopeptidase M8 family)provided by MGI
    Primary source
    MGI:MGI:2444736
    See related
    Ensembl:ENSMUSG00000022802 AllianceGenome:MGI:2444736
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5330415H22Rik
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within cell division. Predicted to be located in cytosol and focal adhesion. Predicted to be active in cytoplasm. Orthologous to human LMLN (leishmanolysin like peptidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 2.2), testis adult (RPKM 2.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmln in Genome Data Viewer
    Location:
    16 B3; 16 23.6 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32881974..32948065)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33061870..33127695)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_40679 Neighboring gene STARR-positive B cell enhancer ABC_E8628 Neighboring gene IQ motif containing G Neighboring gene STARR-positive B cell enhancer ABC_E2460 Neighboring gene ribosomal protein L35A Neighboring gene microRNA 1947 Neighboring gene predicted gene, 38540 Neighboring gene predicted gene, 41447 Neighboring gene predicted gene, 53950

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leishmanolysin-like peptidase
    NP_766411.1
    XP_030104970.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172823.2 → NP_766411.1  leishmanolysin-like peptidase precursor

      See identical proteins and their annotated locations for NP_766411.1

      Status: PROVISIONAL

      Source sequence(s)
      AK030463
      Consensus CDS
      CCDS28127.1
      UniProtKB/Swiss-Prot
      Q8BMN4
      Related
      ENSMUSP00000023497.3, ENSMUST00000023497.3
      Conserved Domains (1) summary
      cl19482
      Location:96 → 628
      Peptidase_M8; Leishmanolysin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32881974..32948065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249110.1 → XP_030104970.1  leishmanolysin-like peptidase isoform X1

      Conserved Domains (1) summary
      cl19482
      Location:2 → 385
      Peptidase_M8; Leishmanolysin

    RNA

    1. XR_384560.4 RNA Sequence

    2. XR_384561.4 RNA Sequence

    3. XR_384563.4 RNA Sequence

    4. XR_384562.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMN4.1 GenPept UniProtKB/Swiss-Prot:Q8BMN4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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