Adrb1 adrenergic receptor, beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adrb1provided by MGI
Official Full Name: adrenergic receptor, beta 1provided by MGI
Primary source: MGI:MGI:87937
See related: Ensembl:ENSMUSG00000035283 AllianceGenome:MGI:87937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adrb-1; beta-AR
Summary: Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in positive regulation of cold-induced thermogenesis and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Located in membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including brain; exocrine gland; hemolymphoid system gland; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 51.96 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (56710549..56713582)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (56722117..56725150)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protective effects of Galphai3 deficiency in a murine heart-failure model of beta1-adrenoceptor overexpression.
Title: Protective effects of Gα(i3) deficiency in a murine heart-failure model of β(1)-adrenoceptor overexpression.
Epac1 participates in beta1-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes.
Title: Epac1 participates in β(1)-adrenoreceptor autoantibody-mediated decreased autophagic flux in cardiomyocytes.
Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice.
Title: Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice.
Pharmacological activation of the C5a receptor leads to stimulation of the beta-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Title: Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes.
Title: N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes.
Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute beta-Adrenergic Receptor Stimulation In Vivo.
Title: Quantitative Analysis of the Cardiac Phosphoproteome in Response to Acute β-Adrenergic Receptor Stimulation In Vivo.
Intracellular beta1-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility.
Title: Intracellular β(1)-Adrenergic Receptors and Organic Cation Transporter 3 Mediate Phospholamban Phosphorylation to Enhance Cardiac Contractility.
Data indicate that G protein-coupled estrogen receptor 1 (GPER) functions as an intrinsic component of adrenergic receptor beta 1 (beta1AR) signaling to moderate myocardial Ca(2+) dynamics and contraction.
Title: Regulation of beta adrenoceptor-mediated myocardial contraction and calcium dynamics by the G protein-coupled estrogen receptor 1.
the findings of the present study indicate that stimulation of a1 - and b1/2 -ARs markedly reduced serum TG steady-state levels as a result of alterations in TG synthesis, uptake, transport, hydrolysis, metabolism and clearance, an effect induced by PPARa independent mechanisms
Title: Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.
Mice carrying the beta1AR A187V mutation demonstrated short sleep behavior. This receptor is highly expressed in the dorsal pons and that these ADRB1(+) neurons are active during rapid eye movement (REM) sleep and wakefulness.
Title: A Rare Mutation of β(1)-Adrenergic Receptor Affects Sleep/Wake Behaviors.

Submit: New GeneRIF Correction See all GeneRIFs (83)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Adrb1 (e-PCR), detects polymorphism
- UniSTS:471068

Adrb1 (e-PCR), detects polymorphism
- UniSTS:256461

UniSTS:141043 (e-PCR)
- UniSTS:141043

Adrb1 (e-PCR), detects polymorphism
- UniSTS:141043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha-2A adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables amine binding	ISO Inferred from Sequence Orthology more info
enables beta1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables beta1-adrenergic receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables beta1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brown fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within diet induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heat generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of heart contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of heart rate by epinephrine-norepinephrine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of the force of heart contraction by epinephrine-norepinephrine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of the force of heart contraction by norepinephrine	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cold	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuronal dense core vesicle	EXP Inferred from Experiment more info	PubMed
is_active_in neuronal dense core vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-1 adrenergic receptor

Names: beta 1-AR; beta-1 adrenoceptor; beta-1 adrenoreceptor; cardiac beta adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007419.3 → NP_031445.2 beta-1 adrenergic receptor

See identical proteins and their annotated locations for NP_031445.2

Status: VALIDATED

Source sequence(s)

AC158549

Consensus CDS

CCDS29919.1

UniProtKB/Swiss-Prot

B2RVY4, P34971

UniProtKB/TrEMBL

Q9CRR2

Related

ENSMUSP00000040847.5, ENSMUST00000038949.6

Conserved Domains (1) summary

cd15958
Location:59 → 376

7tmA_Beta1_AR; beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors