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    GUCY1B2 guanylate cyclase 1 soluble subunit beta 2 (pseudogene) [ Homo sapiens (human) ]

    Gene ID: 2974, updated on 16-Jan-2024

    Summary

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    Official Symbol
    GUCY1B2provided by HGNC
    Official Full Name
    guanylate cyclase 1 soluble subunit beta 2 (pseudogene)provided by HGNC
    Primary source
    HGNC:HGNC:4686
    See related
    Ensembl:ENSG00000293412 MIM:603695; AllianceGenome:HGNC:4686
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GC-SB2
    Summary
    Predicted to enable several functions, including GTP binding activity; guanylate cyclase activity; and heme binding activity. Predicted to be involved in cGMP-mediated signaling. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See GUCY1B2 in Genome Data Viewer
    Location:
    13q14.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (50994511..51066157, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (50209471..50281130, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (51568647..51640293, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene deleted in lymphocytic leukemia 7 Neighboring gene DLEU7 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:51416758-51417684 Neighboring gene RNASEH2B antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:51467712-51468251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5361 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7771 Neighboring gene ribonuclease H2 subunit B Neighboring gene ReSE screen-validated silencer GRCh37_chr13:51575479-51575649 Neighboring gene RNA, 5S ribosomal pseudogene 29 Neighboring gene chromosome 13 open reading frame 42 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:51684668-51685867 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:51686552-51687751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5364 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:51722404-51723295 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:51742441-51743360 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:51743361-51744280 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:51744281-51745200 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:51747961-51748880 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:51748881-51749799 Neighboring gene uncharacterized LOC107984554 Neighboring gene ribosomal protein L5 pseudogene 31 Neighboring gene PRELI domain containing 3B pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase beta2 mRNA translation. Vazquez-Padron RI, et al. FEBS J, 2008 Jul. PMID 18565106
    2. The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. Behrends S, et al. Biochem Biophys Res Commun, 2000 Apr 29. PMID 10777682
    3. Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses. Bellamy TC, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10717006, Free PMC Article
    4. Expression of nitric oxide-sensitive guanylyl cyclase subunits in human corpus cavernosum. Behrends S, et al. Biochem Pharmacol, 2000 Mar 15. PMID 10677588
    5. Assignment of GUCY1B2, the human homologue of a candidate gene for hypertension, to chromosome bands 13q14.2-->q14.3 by in situ hybridization. Malterer A, et al. Cytogenet Cell Genet, 1999. PMID 10449911

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.
    2. Findings suggest that the soluble guanylyl cyclase (sGC) beta2 5'-UTRs have internal ribosome entry site activity that may permit sGC beta2 expression under conditions that are not optimal for scanning-dependent translation.
      Title: An internal ribosome entry site mediates the initiation of soluble guanylyl cyclase beta2 mRNA translation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
    EBI GWAS Catalog

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • guanylate cyclase 1 solube subunit beta 2 (pseudogene)
    • guanylate cyclase 1, soluble, beta 2 (pseudogene)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003923.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF038499, AI247180, AL160157
      Related
      ENST00000493639.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      50994511..51066157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      50209471..50281130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004129.2: Suppressed sequence

      Description
      NM_004129.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

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