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Arfip1 ADP-ribosylation factor interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 99889, updated on 5-Mar-2024

Summary

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Official Symbol
Arfip1provided by MGI
Official Full Name
ADP-ribosylation factor interacting protein 1provided by MGI
Primary source
MGI:MGI:1277120
See related
Ensembl:ENSMUSG00000074513 Ensembl:ENSMUSG00000102805 AllianceGenome:MGI:1277120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arfaptin; D3Ertd598e; 2310030I10Rik
Summary
Predicted to enable phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in intracellular protein transport; negative regulation of retrograde transport, endosome to Golgi; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of protein secretion. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in trans-Golgi network membrane. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 12.6), placenta adult (RPKM 11.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F1; 3 37.7 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84403400..84490075, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84496093..84582751, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene FH2 domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:84346416-84346716 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 35410 Neighboring gene tigger transposable element derived 4 Neighboring gene predicted gene, 46836

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arfaptin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081093.2 → NP_001074562.1  arfaptin-1 isoform 1

    See identical proteins and their annotated locations for NP_001074562.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102224
    Consensus CDS
    CCDS38466.1
    UniProtKB/Swiss-Prot
    A2RSX9, E9Q3G5, G5E8V9
    Related
    ENSMUSP00000122964.2, ENSMUST00000143514.3
    Conserved Domains (1) summary
    cd07660
    Location:155 → 355
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  2. NM_001293801.1 → NP_001280730.1  arfaptin-1 isoform 2

    See identical proteins and their annotated locations for NP_001280730.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102224
    Consensus CDS
    CCDS79931.1
    UniProtKB/TrEMBL
    A2RSX9
    Related
    ENSMUSP00000096588.4, ENSMUST00000098990.10
    Conserved Domains (1) summary
    cd07660
    Location:123 → 323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    84403400..84490075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502484.4 → XP_006502547.1  arfaptin-1 isoform X3

    UniProtKB/TrEMBL
    E9QAY5, Q3TVE1
    Related
    ENSMUSP00000116393.2, ENSMUST00000154148.8
    Conserved Domains (1) summary
    cd07660
    Location:34 → 234
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  2. XM_036163483.1 → XP_036019376.1  arfaptin-1 isoform X2

    Conserved Domains (1) summary
    cd07660
    Location:123 → 323
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

  3. XM_006502482.4 → XP_006502545.1  arfaptin-1 isoform X1

    See identical proteins and their annotated locations for XP_006502545.1

    UniProtKB/Swiss-Prot
    A2RSX9, E9Q3G5, G5E8V9
    Conserved Domains (1) summary
    cd07660
    Location:155 → 355
    BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8V9.1 GenPept UniProtKB/Swiss-Prot:G5E8V9

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