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Taf13 TATA-box binding protein associated factor 13 [ Mus musculus (house mouse) ]

Gene ID: 99730, updated on 11-Apr-2024

Summary

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Official Symbol
Taf13provided by MGI
Official Full Name
TATA-box binding protein associated factor 13provided by MGI
Primary source
MGI:MGI:1913500
See related
Ensembl:ENSMUSG00000048100 AllianceGenome:MGI:1913500
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TAFII18; 1810004N01Rik; 2010309N11Rik
Summary
Enables DNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Located in nucleus. Is expressed in cranial ganglion; limb mesenchyme; sensory organ; submandibular gland primordium; and tail dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 19.4), bladder adult (RPKM 12.3) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Taf13 in Genome Data Viewer
Location:
3 F3; 3 47.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108479015..108489384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108571699..108582068)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:108365309-108365496 Neighboring gene STARR-positive B cell enhancer ABC_E3459 Neighboring gene transmembrane protein 167B Neighboring gene small Cajal body-specific RNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E1629 Neighboring gene STARR-positive B cell enhancer ABC_E6105 Neighboring gene WD repeat domain 47 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene chloride channel CLIC-like 1 Neighboring gene G-protein signalling modulator 2 (AGS3-like, C. elegans)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
  2. Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Langer D, et al. Nat Commun, 2016 Mar 30. PMID 27026076, Free PMC Article
  3. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article
  4. Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Tatarakis A, et al. Mol Cell, 2008 Aug 22. PMID 18722179
  5. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 13
Names
TAF(II)18
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAF13 RNA polymerase II, TATA box-binding protein-associated factor
TAFII-18
TBP-associated factor, RNA polymerase II, K, 18kD
transcription initiation factor TFIID 18 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025444.2 → NP_079720.1  transcription initiation factor TFIID subunit 13

    See identical proteins and their annotated locations for NP_079720.1

    Status: PROVISIONAL

    Source sequence(s)
    AK007339
    Consensus CDS
    CCDS17764.1
    UniProtKB/Swiss-Prot
    P61216, Q3TVE8
    Related
    ENSMUSP00000121346.2, ENSMUST00000143054.2
    Conserved Domains (1) summary
    cd07978
    Location:29 → 118
    TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108479015..108489384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61216.1 GenPept UniProtKB/Swiss-Prot:P61216

Gene LinkOut

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