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Cept1 choline/ethanolaminephosphotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 99712, updated on 21-Apr-2024

Summary

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Official Symbol
Cept1provided by MGI
Official Full Name
choline/ethanolaminephosphotransferase 1provided by MGI
Primary source
MGI:MGI:2139793
See related
Ensembl:ENSMUSG00000040774 AllianceGenome:MGI:2139793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mCEPT1; 9930118K05Rik
Summary
Enables phosphotransferase activity, for other substituted phosphate groups. Acts upstream of or within phosphatidylcholine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in alimentary system; cranium; nervous system; nose; and urinary system. Orthologous to human CEPT1 (choline/ethanolamine phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.4), liver E18 (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.3; 3 46.49 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106409576..106455118, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106502260..106547802, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene chitinase-like 6 Neighboring gene STARR-seq mESC enhancer starr_08648 Neighboring gene STARR-positive B cell enhancer ABC_E6101 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106252568-106252751 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:106264918-106265101 Neighboring gene RIKEN cDNA 2010016I18 gene Neighboring gene STARR-seq mESC enhancer starr_08649 Neighboring gene DENN domain containing 2D Neighboring gene STARR-seq mESC enhancer starr_08650 Neighboring gene STARR-positive B cell enhancer ABC_E6102 Neighboring gene DNA-damage regulated autophagy modulator 2 Neighboring gene STARR-seq mESC enhancer starr_08651 Neighboring gene STARR-seq mESC enhancer starr_08652 Neighboring gene STARR-seq mESC enhancer starr_08653 Neighboring gene ligand dependent nuclear receptor interacting factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E10205 Neighboring gene CD53 antigen

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function. Funai K, et al. Diabetes, 2016 Feb. PMID 26512026, Free PMC Article
  2. Cross-talk between remodeling and de novo pathways maintains phospholipid balance through ubiquitination. Butler PL, et al. J Biol Chem, 2010 Feb 26. PMID 20018880, Free PMC Article
  3. Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. Kulinski A, et al. J Biol Chem, 2002 Aug 30. PMID 12072432
  4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-alkenyl-2-acylglycerol choline phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
choline/ethanolaminephosphotransferase 1
Names
1-alkenyl-2-acylglycerol choline phosphotransferase
NP_001280623.1
NP_001344747.1
NP_001344748.1
NP_598630.2
XP_006502534.1
XP_011238638.1
XP_036019375.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293694.1 → NP_001280623.1  choline/ethanolaminephosphotransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001280623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and contains an alternate exon but maintains the reading frame compared to variant 1. The encoded isoform (4) is the same length as isoform 1, but contains a distinct internal segment.
    Source sequence(s)
    AC117200, AC140380
    Consensus CDS
    CCDS79995.1
    UniProtKB/Swiss-Prot
    Q8BGS7
    Related
    ENSMUSP00000037277.8, ENSMUST00000039153.14
    Conserved Domains (1) summary
    cl00453
    Location:43 → 407
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. NM_001357818.1 → NP_001344747.1  choline/ethanolaminephosphotransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117200, AC140380, CO425529, CX223901
    Consensus CDS
    CCDS17723.1
    UniProtKB/Swiss-Prot
    Q8BGS7, Q8VC64
    Conserved Domains (1) summary
    cl00453
    Location:43 → 407
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. NM_001357819.1 → NP_001344748.1  choline/ethanolaminephosphotransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117200, AC140380
    Consensus CDS
    CCDS17723.1
    UniProtKB/Swiss-Prot
    Q8BGS7, Q8VC64
    Conserved Domains (1) summary
    cl00453
    Location:43 → 407
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  4. NM_133869.4 → NP_598630.2  choline/ethanolaminephosphotransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_598630.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AK037116, BY226430
    Consensus CDS
    CCDS17723.1
    UniProtKB/Swiss-Prot
    Q8BGS7, Q8VC64
    Related
    ENSMUSP00000065743.5, ENSMUST00000068301.11
    Conserved Domains (1) summary
    cl00453
    Location:43 → 407
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106409576..106455118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502471.5 → XP_006502534.1  choline/ethanolaminephosphotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006502534.1

    UniProtKB/Swiss-Prot
    Q8BGS7, Q8VC64
    Related
    ENSMUSP00000112509.2, ENSMUST00000121231.8
    Conserved Domains (1) summary
    cl00453
    Location:43 → 407
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  2. XM_011240336.3 → XP_011238638.1  choline/ethanolaminephosphotransferase 1 isoform X2

    Conserved Domains (1) summary
    cl00453
    Location:43 → 209
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

  3. XM_036163482.1 → XP_036019375.1  choline/ethanolaminephosphotransferase 1 isoform X2

    Conserved Domains (1) summary
    cl00453
    Location:43 → 209
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

RNA

  1. XR_375610.4 RNA Sequence

  2. XR_001783787.3 RNA Sequence

  3. XR_003954431.2 RNA Sequence

  4. XR_001783786.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGS7.1 GenPept UniProtKB/Swiss-Prot:Q8BGS7

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