Dpyd dihydropyrimidine dehydrogenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpydprovided by MGI
Official Full Name: dihydropyrimidine dehydrogenaseprovided by MGI
Primary source: MGI:MGI:2139667
See related: Ensembl:ENSMUSG00000033308 AllianceGenome:MGI:2139667
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DPD; DHPDHase; E330028L06Rik
Summary: Enables dihydropyrimidine dehydrogenase (NADP+) activity. Involved in pyrimidine nucleoside monophosphate catabolic process. Acts upstream of or within pyrimidine nucleobase catabolic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculature; and sensory organ. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 19.3), large intestine adult (RPKM 5.5) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 51.96 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (118355758..119226573)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (118562109..119432924)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice.
Title: The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice.
DPD gene expression is regulated first at the mRNA level when the hepatocytes enter the cell cycle. There is little regulation at the translational level. Cell proliferation rate is influences the enzyme activity modification.
Title: Regulation of dihydropyrimidine dehydrogenase gene expression in regenerating mouse liver.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)
Endonuclease-mediated (1)

General gene information

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Markers

mHAa23e6.seq (e-PCR)
- UniSTS:125957

mHAa23g10.seq (e-PCR)
- UniSTS:125959

D3Mit79 (e-PCR), detects polymorphism
- UniSTS:129849

NoName (e-PCR)
- UniSTS:494239

39.MMHAP58FRE12.seq (e-PCR)
- UniSTS:124326

AI315208 (e-PCR)
- UniSTS:159186

D3Mit344 (e-PCR), detects polymorphism
- UniSTS:129784

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables dihydropyrimidine dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidine dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydropyrimidine dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables uracil binding	IBA Inferred from Biological aspect of Ancestor more info
enables uracil binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in dCMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dTMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in dUMP catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleobase catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pyrimidine nucleobase catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleobase catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in thymidine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in thymine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thymine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in uracil catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in uracil catabolic process	ISO Inferred from Sequence Orthology more info
involved_in uracil metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydropyrimidine dehydrogenase [NADP(+)]

Names: dihydrothymine dehydrogenase; dihydrouracil dehydrogenase

NP_740748.1

EC 1.3.1.2

XP_011238620.1

EC 1.3.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_170778.3 → NP_740748.1 dihydropyrimidine dehydrogenase [NADP(+)]

See identical proteins and their annotated locations for NP_740748.1

Status: VALIDATED

Source sequence(s)

AC110513, AC115012, AC115017, AC115935, AC116409, AC121544, AC122183, AC152401, AC161223

Consensus CDS

CCDS17797.1

UniProtKB/Swiss-Prot

Q8CHR6

UniProtKB/TrEMBL

Q80XT4

Related

ENSMUSP00000039429.8, ENSMUST00000039177.12

Conserved Domains (6) summary

PRK08318
Location:532 → 1012

PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated

PRK11749
Location:53 → 511

PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional

cd02940
Location:532 → 834

DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...

pfam13187
Location:953 → 997

Fer4_9; 4Fe-4S dicluster domain

pfam13450
Location:194 → 238

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam14691
Location:58 → 168

Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

118355758..119226573

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240318.2 → XP_011238620.1 dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

Conserved Domains (2) summary

PRK11749
Location:53 → 511

PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional

cl21457
Location:532 → 580

TIM; TIM-like beta/alpha barrel domains