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Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 [ Mus musculus (house mouse) ]

Gene ID: 99371, updated on 25-Apr-2024

Summary

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Official Symbol
Arfgef2provided by MGI
Official Full Name
ADP ribosylation factor guanine nucleotide exchange factor 2provided by MGI
Primary source
MGI:MGI:2139354
See related
Ensembl:ENSMUSG00000074582 AllianceGenome:MGI:2139354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIG2; E230011G24Rik
Summary
Predicted to enable several functions, including GABA receptor binding activity; guanyl-nucleotide exchange factor activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; positive regulation of tumor necrosis factor production; and receptor recycling. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and recycling endosome. Is expressed in brown fat; central nervous system; duodenum; thymus; and trunk. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 9.9), lung adult (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 87.22 cM
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (166647371..166739972)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (166805451..166898052)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31117 Neighboring gene STARR-positive B cell enhancer ABC_E6021 Neighboring gene transformation related protein 53 regulating kinase B Neighboring gene STARR-positive B cell enhancer ABC_E10161 Neighboring gene STARR-positive B cell enhancer ABC_E2654 Neighboring gene STARR-seq mESC enhancer starr_06416 Neighboring gene STARR-positive B cell enhancer ABC_E2655 Neighboring gene predicted gene, 31204 Neighboring gene chromosome segregation 1 like Neighboring gene staufen double-stranded RNA binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9541

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene. Grzmil P, et al. Int J Dev Biol, 2010. PMID 20857375
  2. Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. Lu J, et al. J Comp Neurol, 2006 Jan 20. PMID 16320251
  3. Fas-associated factor (FAF1) is required for the early cleavage-stages of mouse embryo. Adham IM, et al. Mol Hum Reprod, 2008 Apr. PMID 18303090
  4. Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation. Zhang J, et al. J Neurosci, 2013 Oct 2. PMID 24089482, Free PMC Article
  5. The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN). Lowery J, et al. J Biol Chem, 2013 Apr 19. PMID 23386609, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.
    Title: Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.
  2. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.
    Title: The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
  3. Big2 inhibition promotes Filamin A phosphorylation, thereby disrupting cell intrinsic neuronal migration.
    Title: Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.
  4. Results indicate that murine BIG2 is essential for early embryonic development.
    Title: Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables myosin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endomembrane system organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in symmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
brefeldin A-inhibited guanine nucleotide-exchange protein 2
Names
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
brefeldin A-inhibited GEP 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085495.2 → NP_001078964.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2

    See identical proteins and their annotated locations for NP_001078964.1

    Status: VALIDATED

    Source sequence(s)
    AL591703, AL591911
    Consensus CDS
    CCDS38335.1
    UniProtKB/Swiss-Prot
    A2A5R2
    Related
    ENSMUSP00000096677.4, ENSMUST00000099078.10
    Conserved Domains (1) summary
    PLN03076
    Location:11 → 1718
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    166647371..166739972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500484.4 → XP_006500547.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X2

    Conserved Domains (1) summary
    PLN03076
    Location:11 → 1695
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

  2. XM_006500483.4 → XP_006500546.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1

    Conserved Domains (1) summary
    PLN03076
    Location:11 → 1717
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

  3. XM_036162763.1 → XP_036018656.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X3

    Conserved Domains (1) summary
    PLN03076
    Location:11 → 1694
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional

  4. XM_030252278.2 → XP_030108138.1  brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X4

    Conserved Domains (1) summary
    PLN03076
    Location:189 → 1530
    PLN03076; ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A5R2.1 GenPept UniProtKB/Swiss-Prot:A2A5R2

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