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Dnajc24 DnaJ heat shock protein family (Hsp40) member C24 [ Mus musculus (house mouse) ]

Gene ID: 99349, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc24provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C24provided by MGI
Primary source
MGI:MGI:1919522
See related
Ensembl:ENSMUSG00000027166 AllianceGenome:MGI:1919522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dph4; Zcsl3; MmDjC7; 1700030A21Rik; 2610027M02Rik
Summary
Predicted to enable ATPase activator activity; ferrous iron binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of ATPase activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human DNAJC24 (DnaJ heat shock protein family (Hsp40) member C24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.3), CNS E14 (RPKM 6.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E3; 2 55.46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (105797053..105833894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (105966708..106003549, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene paired box 6 Neighboring gene STARR-seq mESC enhancer starr_05317 Neighboring gene elongator acetyltransferase complex subunit 4 Neighboring gene Pax6 downstream regulatory region Neighboring gene RB enhancer downstream of Pax6 Neighboring gene STARR-seq mESC enhancer starr_05318 Neighboring gene STARR-seq mESC enhancer starr_05319 Neighboring gene STARR-positive B cell enhancer ABC_E639 Neighboring gene IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:105843384-105843567 Neighboring gene STARR-seq mESC enhancer starr_05320 Neighboring gene doublecortin domain containing 5 Neighboring gene 60S ribosomal protein L39 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05321 Neighboring gene STARR-seq mESC enhancer starr_05322 Neighboring gene predicted gene, 46755

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a new soluble murine J-domain protein that stimulates BiP, Hsc70 and DnaK ATPase activity with different efficiencies. Kroczynska B, et al. Gene, 2001 Aug 8. PMID 11595173
  2. Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. Webb TR, et al. J Cell Sci, 2008 Oct 1. PMID 18765564, Free PMC Article
  3. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mouse that was mutant for the gene, Dph4, was identified.
    Title: Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ATP-dependent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 24
Names
CSL-type zinc finger-containing protein 3
DPH4 homolog (JJJ3, S. cerevisiae)
DnaJ (Hsp40) homolog, subfamily C, member 24
diphthamide biosynthesis protein 4
j domain protein DjC7
zinc finger, CSL-type containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026992.3 → NP_081268.1  dnaJ homolog subfamily C member 24

    See identical proteins and their annotated locations for NP_081268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AK006521, AV331303
    Consensus CDS
    CCDS16501.1
    UniProtKB/Swiss-Prot
    Q91ZF0, Q9D9S7
    Related
    ENSMUSP00000099615.5, ENSMUST00000102555.11
    Conserved Domains (2) summary
    pfam00226
    Location:10 → 78
    DnaJ; DnaJ domain
    pfam05207
    Location:94 → 147
    zf-CSL; CSL zinc finger

RNA

  1. NR_033993.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK006521, AK011571, AV331303

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    105797053..105833894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZF0.4 GenPept UniProtKB/Swiss-Prot:Q91ZF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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