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Cercam cerebral endothelial cell adhesion molecule [ Mus musculus (house mouse) ]

Gene ID: 99151, updated on 5-Mar-2024

Summary

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Official Symbol
Cercamprovided by MGI
Official Full Name
cerebral endothelial cell adhesion moleculeprovided by MGI
Primary source
MGI:MGI:2139134
See related
Ensembl:ENSMUSG00000039787 AllianceGenome:MGI:2139134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ceecam1; 2600006K01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within cell adhesion. Predicted to be located in endoplasmic reticulum. Is expressed in brain ventricular layer; clavicle; craniocervical region bone; and ventral grey horn. Orthologous to human CERCAM (cerebral endothelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 10.7), limb E14.5 (RPKM 10.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 20.76 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29735442..29772857)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (29845094..29882840)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 (fatty acid transporter), member 4 Neighboring gene STARR-seq mESC enhancer starr_04075 Neighboring gene STARR-positive B cell enhancer ABC_E224 Neighboring gene ubiquitin related modifier 1 Neighboring gene microRNA 219a-2 Neighboring gene predicted gene, 54109 Neighboring gene microRNA 219b Neighboring gene RIKEN cDNA 2600006K01 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29724576-29724685 Neighboring gene STARR-positive B cell enhancer ABC_E1583 Neighboring gene outer dense fiber of sperm tails 2 Neighboring gene STARR-positive B cell enhancer ABC_E4425 Neighboring gene GLE1 RNA export mediator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development. Moulson CL, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12697906, Free PMC Article
  2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables procollagen galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive glycosyltransferase 25 family member 3
Names
cerebral endothelial cell adhesion molecule 1
glycosyltransferase 25 family member 3
probable inactive glycosyltransferase 25 family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207298.2 → NP_997181.1  inactive glycosyltransferase 25 family member 3 precursor

    See identical proteins and their annotated locations for NP_997181.1

    Status: VALIDATED

    Source sequence(s)
    AL928926
    Consensus CDS
    CCDS15860.1
    UniProtKB/Swiss-Prot
    A3KGW5
    UniProtKB/TrEMBL
    B2RSF7
    Related
    ENSMUSP00000041622.7, ENSMUST00000047521.7
    Conserved Domains (2) summary
    cd00761
    Location:34 → 157
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cd06532
    Location:318 → 500
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29735442..29772857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498476.5 → XP_006498539.1  inactive glycosyltransferase 25 family member 3 isoform X2

    See identical proteins and their annotated locations for XP_006498539.1

    Conserved Domains (1) summary
    cd06532
    Location:249 → 431
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  2. XM_006498475.5 → XP_006498538.1  inactive glycosyltransferase 25 family member 3 isoform X1

    Conserved Domains (1) summary
    cd06532
    Location:283 → 465
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  3. XM_006498478.3 → XP_006498541.1  inactive glycosyltransferase 25 family member 3 isoform X3

    Conserved Domains (1) summary
    cd06532
    Location:63 → 245
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...

  4. XM_017319356.3 → XP_017174845.1  inactive glycosyltransferase 25 family member 3 isoform X3

    Conserved Domains (1) summary
    cd06532
    Location:63 → 245
    Glyco_transf_25; Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A3KGW5.1 GenPept UniProtKB/Swiss-Prot:A3KGW5

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