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Cep152 centrosomal protein 152 [ Mus musculus (house mouse) ]

Gene ID: 99100, updated on 18-Apr-2024

Summary

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Official Symbol
Cep152provided by MGI
Official Full Name
centrosomal protein 152provided by MGI
Primary source
MGI:MGI:2139083
See related
Ensembl:ENSMUSG00000068394 AllianceGenome:MGI:2139083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0912
Summary
Predicted to enable protein kinase binding activity. Involved in centriole replication and de novo centriole assembly involved in multi-ciliated epithelial cell differentiation. Located in centrosome and deuterosome. Is expressed in brain; pharynx epithelium; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in Seckel syndrome 5 and primary autosomal recessive microcephaly 9. Orthologous to human CEP152 (centrosomal protein 152). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.4), liver E14 (RPKM 3.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 61.76 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125391784..125467081, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125549864..125625174, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr2:125073047-125073348 Neighboring gene STARR-seq mESC enhancer starr_05587 Neighboring gene STARR-seq mESC enhancer starr_05588 Neighboring gene deoxyuridine triphosphatase Neighboring gene fibrillin 1 Neighboring gene STARR-seq mESC enhancer starr_05589 Neighboring gene STARR-positive B cell enhancer ABC_E1254 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9530 Neighboring gene SHC (Src homology 2 domain containing) family, member 4 Neighboring gene predicted gene, 35231 Neighboring gene EP300 interacting inhibitor of differentiation 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Guernsey DL, et al. Am J Hum Genet, 2010 Jul 9. PMID 20598275, Free PMC Article
  2. Cep63 and cep152 cooperate to ensure centriole duplication. Brown NJ, et al. PLoS One, 2013. PMID 23936128, Free PMC Article
  3. Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development. Hamada N, et al. Dev Neurosci, 2022. PMID 35259752
  4. The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis. Zhao H, et al. Nat Cell Biol, 2013 Dec. PMID 24240477
  5. Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Bazzi H, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706806, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in deuterosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
located_in procentriole ISO
Inferred from Sequence Orthology
more info
  
part_of procentriole replication complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein of 152 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081091.1 → NP_001074560.1  centrosomal protein of 152 kDa

    See identical proteins and their annotated locations for NP_001074560.1

    Status: VALIDATED

    Source sequence(s)
    AL928930, AL929166, BX321866
    Consensus CDS
    CCDS38229.1
    UniProtKB/Swiss-Prot
    A2AUM9, Q69ZV8, Q8R0X1
    Related
    ENSMUSP00000087208.3, ENSMUST00000089776.3
    Conserved Domains (5) summary
    COG1390
    Location:1298 → 1422
    NtpE; Archaeal/vacuolar-type H+-ATPase subunit E/Vma4 [Energy production and conversion]
    pfam07106
    Location:281 → 386
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:794 → 803
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:610 → 803
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:977 → 1085
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125391784..125467081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239870.3 → XP_011238172.1  centrosomal protein of 152 kDa isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:620 → 1272
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:238 → 812
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_036162757.1 → XP_036018650.1  centrosomal protein of 152 kDa isoform X6

    Conserved Domains (2) summary
    PTZ00121
    Location:565 → 1074
    PTZ00121; MAEBL; Provisional
    COG0419
    Location:276 → 803
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

  3. XM_036162756.1 → XP_036018649.1  centrosomal protein of 152 kDa isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:619 → 1271
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:235 → 811
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006500474.5 → XP_006500537.1  centrosomal protein of 152 kDa isoform X1

    Conserved Domains (2) summary
    PTZ00121
    Location:619 → 1271
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:237 → 811
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_017319354.3 → XP_017174843.1  centrosomal protein of 152 kDa isoform X5

    Conserved Domains (2) summary
    PTZ00121
    Location:566 → 1075
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:238 → 812
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_011239871.3 → XP_011238173.1  centrosomal protein of 152 kDa isoform X4

    Conserved Domains (2) summary
    PTZ00121
    Location:566 → 1075
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:238 → 812
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_036162760.1 → XP_036018653.1  centrosomal protein of 152 kDa isoform X9

    Conserved Domains (2) summary
    PTZ00121
    Location:358 → 845
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:6 → 582
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_036162758.1 → XP_036018651.1  centrosomal protein of 152 kDa isoform X8

    Conserved Domains (2) summary
    PTZ00121
    Location:390 → 1042
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:6 → 582
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_006500473.4 → XP_006500536.1  centrosomal protein of 152 kDa isoform X7

    Conserved Domains (2) summary
    PTZ00121
    Location:390 → 1042
    PTZ00121; MAEBL; Provisional
    TIGR02168
    Location:8 → 582
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_001783212.3 RNA Sequence

  2. XR_001783214.3 RNA Sequence

  3. XR_001783213.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AUM9.1 GenPept UniProtKB/Swiss-Prot:A2AUM9

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