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Nat10 N-acetyltransferase 10 [ Mus musculus (house mouse) ]

Gene ID: 98956, updated on 13-Apr-2024

Summary

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Official Symbol
Nat10provided by MGI
Official Full Name
N-acetyltransferase 10provided by MGI
Primary source
MGI:MGI:2138939
See related
Ensembl:ENSMUSG00000027185 AllianceGenome:MGI:2138939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA polymerase binding activity; N-acetyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including rRNA acetylation involved in maturation of SSU-rRNA; regulation of cellular macromolecule biosynthetic process; and regulation of centrosome duplication. Predicted to act upstream of or within rRNA processing and tRNA processing. Predicted to be located in midbody. Predicted to be part of telomerase holoenzyme complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; clavicle; cranium bone primordium; early conceptus; and skeletal musculature. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 9.4), CNS E11.5 (RPKM 8.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E2; 2 54.43 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103551603..103593292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103721258..103762954, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103502331-103502560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103522571-103522790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103543647-103543756 Neighboring gene STARR-positive B cell enhancer ABC_E11149 Neighboring gene STARR-positive B cell enhancer ABC_E4483 Neighboring gene STARR-positive B cell enhancer mm9_chr2:103625945-103626245 Neighboring gene cell cycle associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_05272 Neighboring gene STARR-seq mESC enhancer starr_05273 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene 13880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure. Shenshen Wu, et al. Environ Pollut, 2023 Apr 1. PMID 36731737
  2. NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway. Zhang H, et al. Commun Biol, 2022 Sep 6. PMID 36068299, Free PMC Article
  3. NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells. Chen L, et al. Nucleic Acids Res, 2022 Oct 28. PMID 35801907, Free PMC Article
  4. NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression. Wang G, et al. Clin Transl Med, 2022 May. PMID 35522942, Free PMC Article
  5. The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons. Zhang M, et al. J Neurosci, 2023 Apr 26. PMID 36898834, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
    Title: NAT10-mediated ac(4)C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1.
  2. N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
    Title: N-Acetyltransferase 10 represses Uqcr11 and Uqcrb independently of ac4C modification to promote heart regeneration.
  3. NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
    Title: NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
  4. NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.
    Title: NAT10 regulates the repair of UVB-induced DNA damage and tumorigenicity.
  5. NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
    Title: NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer.
  6. Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3.
    Title: Targeting NAT10 protects against sepsis-induced skeletal muscle atrophy by inhibiting ROS/NLRP3.
  7. NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-kappaB pathway in macrophages.
    Title: NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-κB pathway in macrophages.
  8. Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.
    Title: Maternal NAT10 orchestrates oocyte meiotic cell-cycle progression and maturation in mice.
  9. The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
    Title: The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
  10. NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure.
    Title: NAT10 accelerates pulmonary fibrosis through N4-acetylated TGFB1-initiated epithelial-to-mesenchymal transition upon ambient fine particulate matter exposure.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC25461

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables mRNA N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA cytidine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ncRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA cytidine acetyltransferase
Names
18S rRNA cytosine acetyltransferase
novel putative ATPase domain containing protein
NP_001411642.1
NP_694766.1
XP_006500518.1
XP_036018634.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424713.1 → NP_001411642.1  RNA cytidine acetyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX537331

  2. NM_153126.4 → NP_694766.1  RNA cytidine acetyltransferase

    See identical proteins and their annotated locations for NP_694766.1

    Status: VALIDATED

    Source sequence(s)
    BX537331
    Consensus CDS
    CCDS16480.1
    UniProtKB/Swiss-Prot
    Q3UE04, Q6ZPJ7, Q80VD3, Q8BW78, Q8K224
    Related
    ENSMUSP00000028608.7, ENSMUST00000028608.13
    Conserved Domains (6) summary
    COG1444
    Location:20 → 901
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
    pfam05127
    Location:281 → 480
    Helicase_RecD; Helicase
    pfam08351
    Location:107 → 201
    DUF1726; Domain of unknown function (DUF1726)
    pfam09074
    Location:855 → 1005
    Mer2; Mer2
    pfam13718
    Location:528 → 752
    GNAT_acetyltr_2; GNAT acetyltransferase 2
    pfam13725
    Location:775 → 892
    tRNA_bind_2; Possible tRNA binding domain

RNA

  1. NR_188870.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX537331

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103551603..103593292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162741.1 → XP_036018634.1  RNA cytidine acetyltransferase isoform X1

  2. XM_006500455.5 → XP_006500518.1  RNA cytidine acetyltransferase isoform X2

    Conserved Domains (1) summary
    COG1444
    Location:20 → 851
    TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K224.1 GenPept UniProtKB/Swiss-Prot:Q8K224

Gene LinkOut

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