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Usp6nl USP6 N-terminal like [ Mus musculus (house mouse) ]

Gene ID: 98910, updated on 18-Apr-2024

Summary

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Official Symbol
Usp6nlprovided by MGI
Official Full Name
USP6 N-terminal likeprovided by MGI
Primary source
MGI:MGI:2138893
See related
Ensembl:ENSMUSG00000039046 AllianceGenome:MGI:2138893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RNTRE; TRE2NL; mKIAA0019
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; plasma membrane to endosome transport; and retrograde transport, plasma membrane to Golgi. Predicted to be located in plasma membrane. Predicted to be active in cytoplasmic vesicle. Orthologous to human USP6NL (USP6 N-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 3.1), CNS E11.5 (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 3.63 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (6327444..6453107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (6322757..6448296)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230108P19 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:6134393-6134502 Neighboring gene enoyl Coenzyme A hydratase domain containing 3 Neighboring gene predicted gene, 54100 Neighboring gene STARR-positive B cell enhancer ABC_E4414 Neighboring gene predicted gene 13383 Neighboring gene predicted gene, 46730 Neighboring gene STARR-positive B cell enhancer mm9_chr2:6297178-6297479 Neighboring gene STARR-seq mESC enhancer starr_03593 Neighboring gene predicted gene 13388 Neighboring gene predicted gene 13391 Neighboring gene predicted gene, 52546 Neighboring gene STARR-seq mESC enhancer starr_03597 Neighboring gene CUGBP, Elav-like family member 2 Neighboring gene STARR-seq mESC enhancer starr_03598 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:6628430-6628675 Neighboring gene STARR-seq mESC enhancer starr_03599 Neighboring gene STARR-seq mESC enhancer starr_03600 Neighboring gene STARR-seq mESC enhancer starr_03601 Neighboring gene RIKEN cDNA 5031426D15 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The GTPase-activating protein RN-tre controls focal adhesion turnover and cell migration. Palamidessi A, et al. Curr Biol, 2013 Dec 2. PMID 24239119
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane to endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, plasma membrane to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
USP6 N-terminal-like protein
Names
novel TBC domain containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080548.1 → NP_001074017.1  USP6 N-terminal-like protein isoform b

    See identical proteins and their annotated locations for NP_001074017.1

    Status: VALIDATED

    Source sequence(s)
    AK129037, AL845515, BE949333
    Consensus CDS
    CCDS38043.1
    UniProtKB/Swiss-Prot
    A2AR45, A2AR46, Q3U2W3, Q6ZQK8, Q80XC3
    Related
    ENSMUSP00000110587.2, ENSMUST00000114937.8
    Conserved Domains (2) summary
    PTZ00449
    Location:503 → 715
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:97 → 312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_181399.3 → NP_852064.2  USP6 N-terminal-like protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AL845515, BQ938063, CN455065
    Consensus CDS
    CCDS38044.1
    UniProtKB/Swiss-Prot
    Q80XC3
    Related
    ENSMUSP00000043178.9, ENSMUST00000042503.9
    Conserved Domains (2) summary
    smart00164
    Location:120 → 335
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam14820
    Location:590 → 642
    SPRR2; Small proline-rich 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    6327444..6453107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252265.2 → XP_030108125.1  USP6 N-terminal-like protein isoform X7

    Conserved Domains (2) summary
    PTZ00449
    Location:424 → 636
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:18 → 233
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. XM_030252264.1 → XP_030108124.1  USP6 N-terminal-like protein isoform X6

    Conserved Domains (2) summary
    PTZ00449
    Location:432 → 644
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:26 → 241
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  3. XM_036162740.1 → XP_036018633.1  USP6 N-terminal-like protein isoform X7

    Conserved Domains (2) summary
    PTZ00449
    Location:424 → 636
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:18 → 233
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  4. XM_006497570.4 → XP_006497633.1  USP6 N-terminal-like protein isoform X5

    Conserved Domains (2) summary
    PTZ00449
    Location:454 → 666
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:48 → 263
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  5. XM_036162739.1 → XP_036018632.1  USP6 N-terminal-like protein isoform X4

    Conserved Domains (2) summary
    PTZ00449
    Location:462 → 674
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:56 → 271
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  6. XM_006497569.5 → XP_006497632.1  USP6 N-terminal-like protein isoform X2

    See identical proteins and their annotated locations for XP_006497632.1

    UniProtKB/Swiss-Prot
    A2AR45, A2AR46, Q3U2W3, Q6ZQK8, Q80XC3
    Conserved Domains (2) summary
    PTZ00449
    Location:503 → 715
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:97 → 312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  7. XM_036162738.1 → XP_036018631.1  USP6 N-terminal-like protein isoform X3

    Conserved Domains (2) summary
    PTZ00449
    Location:479 → 691
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:73 → 288
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  8. XM_006497568.5 → XP_006497631.1  USP6 N-terminal-like protein isoform X1

    Conserved Domains (2) summary
    PTZ00449
    Location:520 → 732
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:114 → 329
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  9. XM_011238993.2 → XP_011237295.1  USP6 N-terminal-like protein isoform X6

    See identical proteins and their annotated locations for XP_011237295.1

    Conserved Domains (2) summary
    PTZ00449
    Location:432 → 644
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00164
    Location:26 → 241
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XC3.2 GenPept UniProtKB/Swiss-Prot:Q80XC3

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