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Fcrla Fc receptor-like A [ Mus musculus (house mouse) ]

Gene ID: 98752, updated on 5-Mar-2024

Summary

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Official Symbol
Fcrlaprovided by MGI
Official Full Name
Fc receptor-like Aprovided by MGI
Primary source
MGI:MGI:2138647
See related
Ensembl:ENSMUSG00000038421 AllianceGenome:MGI:2138647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FCRL; FREB; Fcrx; FCRL1; Freb1; mFREB; mFcrX; Fcrlm1
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human FCRLA (Fc receptor like A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 43.6), mammary gland adult (RPKM 10.0) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 77.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170745163..170755169, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170917594..170932216, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene STARR-positive B cell enhancer ABC_E5844 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9496 Neighboring gene STARR-positive B cell enhancer ABC_E4384 Neighboring gene STARR-seq mESC enhancer starr_03000 Neighboring gene predicted gene, 39701 Neighboring gene STARR-seq mESC enhancer starr_03002 Neighboring gene Fc receptor, IgG, low affinity IIb Neighboring gene STARR-positive B cell enhancer ABC_E2584

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential expression of FCRLA in naïve and activated mouse B cells. Reshetnikova ES, et al. Cell Immunol, 2012. PMID 22078318, Free PMC Article
  2. Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma. Inozume T, et al. J Invest Dermatol, 2007 Dec. PMID 17625599
  3. Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses. Wilson TJ, et al. J Immunol, 2010 Sep 1. PMID 20668221
  4. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. Davis RS, et al. Int Immunol, 2002 Sep. PMID 12202404
  5. An unusual Fc receptor-related protein expressed in human centroblasts. Facchetti F, et al. Proc Natl Acad Sci U S A, 2002 Mar 19. PMID 11891275, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion.
    Title: Differential expression of FCRLA in naïve and activated mouse B cells.
  2. FcRLA protein is expressed exclusively in all mouse B cells, where it plays a role in immunoglobulin assembly that can be compensated for by other proteins.
    Title: Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.
  3. murine FCRLA (mFCRLA) is expressed and distributed in murine tissues similar to hFCRLA
    Title: Dendritic cells transduced with autoantigen FCRLA induce cytotoxic lymphocytes and vaccinate against murine B-cell lymphoma.
  4. may function as a secreted or intracellular protein in normal and neoplastic B cells
    Title: Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fc receptor-like A
Names
Fc receptor related X
Fc receptor related protein X
Fc receptor-like mucin-like 1
fc receptor homolog expressed in B-cells
fc receptor-like and mucin-like protein 1
fc receptor-like protein
fc receptor-related protein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160215.1 → NP_001153687.1  Fc receptor-like A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001153687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BB219290, BC064708
    Consensus CDS
    CCDS48440.1
    UniProtKB/Swiss-Prot
    Q920A9
    Related
    ENSMUSP00000036380.8, ENSMUST00000046322.14
    Conserved Domains (3) summary
    smart00410
    Location:189 → 262
    IG_like; Immunoglobulin like
    pfam13927
    Location:182 → 253
    Ig_3; Immunoglobulin domain
    cl11960
    Location:90 → 176
    Ig; Immunoglobulin domain

  2. NM_145141.2 → NP_660123.1  Fc receptor-like A isoform 2 precursor

    See identical proteins and their annotated locations for NP_660123.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    BB219290, BB637253, BC064708
    Consensus CDS
    CCDS48439.1
    UniProtKB/Swiss-Prot
    Q3T9Q2, Q8K3U9, Q8VHP5, Q920A9
    Related
    ENSMUSP00000124853.2, ENSMUST00000159171.2
    Conserved Domains (3) summary
    smart00410
    Location:188 → 261
    IG_like; Immunoglobulin like
    pfam13927
    Location:181 → 252
    Ig_3; Immunoglobulin domain
    cl11960
    Location:89 → 175
    Ig; Immunoglobulin domain

RNA

  1. NR_027666.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This creates an in-frame stop codon and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to encode a protein.
    Source sequence(s)
    BB219290, BC064708, CJ080700

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170745163..170755169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497072.4 → XP_006497135.1  Fc receptor-like A isoform X1

    Conserved Domains (2) summary
    pfam13927
    Location:121 → 191
    Ig_3; Immunoglobulin domain
    cl11960
    Location:28 → 114
    Ig; Immunoglobulin domain

RNA

  1. XR_003947561.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920A9.1 GenPept UniProtKB/Swiss-Prot:Q920A9

Gene LinkOut

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