U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnb2 potassium voltage gated channel, Shab-related subfamily, member 2 [ Mus musculus (house mouse) ]

Gene ID: 98741, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Kcnb2provided by MGI
Official Full Name
potassium voltage gated channel, Shab-related subfamily, member 2provided by MGI
Primary source
MGI:MGI:99632
See related
Ensembl:ENSMUSG00000092083 AllianceGenome:MGI:99632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv2.2; 9630047L19Rik
Summary
Predicted to enable delayed rectifier potassium channel activity; protein heterodimerization activity; and transmembrane transporter binding activity. Predicted to be involved in potassium ion transmembrane transport and protein localization to plasma membrane. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in neuronal cell body membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in dendrite and neuronal cell body. Predicted to be integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; lung; primitive bladder; and sensory organ. Orthologous to human KCNB2 (potassium voltage-gated channel subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.3), cortex adult (RPKM 1.1) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 A3; 1 4.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (15357149..15793975)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (15286925..15723751)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00317 Neighboring gene predicted gene 5048 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 51616 Neighboring gene predicted gene, 51617 Neighboring gene STARR-seq mESC enhancer starr_00321 Neighboring gene STARR-seq mESC enhancer starr_00322 Neighboring gene predicted gene, 25227 Neighboring gene predicted gene, 25168 Neighboring gene peptidylprolyl isomerase A pseudogene 1_109.1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons. Regnier G, et al. Physiol Rep, 2016 Mar. PMID 27033450, Free PMC Article
  2. Kv2.2: a novel molecular target to study the role of basal forebrain GABAergic neurons in the sleep-wake cycle. Hermanstyne TO, et al. Sleep, 2013 Dec 1. PMID 24293758, Free PMC Article
  3. Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system. Tong H, et al. J Neurosci, 2013 May 22. PMID 23699522, Free PMC Article
  4. Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. Johnston J, et al. J Physiol, 2008 Jul 15. PMID 18511484, Free PMC Article
  5. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons. Bishop HI, et al. Front Mol Neurosci, 2018. PMID 29403353, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings demonstrate a conserved in vivo function for Kv2 family members in remodeling neuronal endoplasmic reticulum-plasma membrane junctions.
    Title: Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels.
  2. The fractional contribution of Kv2.2-mediated currents relative to IK decreases during the postnatal maturation of dorsal root ganglion neurons.
    Title: The contribution of Kv2.2-mediated currents decreases during the postnatal development of mouse dorsal root ganglion neurons.
  3. The protein levels of KV4.3 and KV2.2 were up-regulated in the hypertrophic smooth muscle cell membrane.
    Title: Voltage dependent potassium channel remodeling in murine intestinal smooth muscle hypertrophy induced by partial obstruction.
  4. This study demonistrated that the contribution of Kv2.2 potassium channels in regulating neuronal excitability and a specific role in hearing protection after an acoustic insult. Kv2.2 is expressed in two nuclei of the superior olivary complex.
    Title: Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system.
  5. Kv2.2 modulates somatostatin release in delta-cells.
    Title: The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
  6. These data offer Kv2.2 as a molecular target to study the role of the specific subpopulation of basal forebrain GABAergic neurons.
    Title: Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.
  7. It was concluded that Kv2.2-containing channels have a distinctive initial segment location and crucial function in maintaining AP amplitude by regulating the interspike potential during high frequency firing.
    Title: Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
potassium voltage-gated channel subfamily B member 2
Names
voltage-gated potassium channel subunit Kv2.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098528.3 → NP_001091998.1  potassium voltage-gated channel subfamily B member 2

    See identical proteins and their annotated locations for NP_001091998.1

    Status: VALIDATED

    Source sequence(s)
    AC126049, AC166075
    Consensus CDS
    CCDS48222.1
    UniProtKB/Swiss-Prot
    A6H8H5, E9Q5T7
    Related
    ENSMUSP00000135382.2, ENSMUST00000175681.3
    Conserved Domains (5) summary
    smart00225
    Location:37 → 143
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:230 → 428
    Ion_trans; Ion transport protein
    pfam02214
    Location:37 → 136
    BTB_2; BTB/POZ domain
    pfam03521
    Location:471 → 755
    Kv2channel; Kv2 voltage-gated K+ channel
    pfam07885
    Location:341 → 422
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    15357149..15793975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495597.5 → XP_006495660.1  potassium voltage-gated channel subfamily B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006495660.1

    Conserved Domains (2) summary
    pfam00520
    Location:1 → 183
    Ion_trans; Ion transport protein
    pfam03521
    Location:226 → 510
    Kv2channel; Kv2 voltage-gated K+ channel

  2. XM_006495596.3 → XP_006495659.1  potassium voltage-gated channel subfamily B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006495659.1

    Conserved Domains (2) summary
    pfam00520
    Location:1 → 183
    Ion_trans; Ion transport protein
    pfam03521
    Location:226 → 510
    Kv2channel; Kv2 voltage-gated K+ channel

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033195.1: Suppressed sequence

    Description
    NM_001033195.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6H8H5.2 GenPept UniProtKB/Swiss-Prot:A6H8H5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous