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Rab3gap2 RAB3 GTPase activating protein subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 98732, updated on 11-Apr-2024

Summary

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Official Symbol
Rab3gap2provided by MGI
Official Full Name
RAB3 GTPase activating protein subunit 2provided by MGI
Primary source
MGI:MGI:1916043
See related
Ensembl:ENSMUSG00000039318 AllianceGenome:MGI:1916043
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0839; 5830469C09; RAB3-GAP150; 1110059F07Rik; 2010002H18Rik
Summary
Predicted to enable enzyme regulator activity and small GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including establishment of protein localization to endoplasmic reticulum membrane; positive regulation of organelle organization; and positive regulation of protein lipidation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in alimentary system; genitourinary system; skin; and vascular system. Human ortholog(s) of this gene implicated in Martsolf syndrome and Warburg micro syndrome 2. Orthologous to human RAB3GAP2 (RAB3 GTPase activating non-catalytic protein subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 9.3), cortex adult (RPKM 8.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H5; 1 89.45 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (184936287..185018953)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185204088..185286756)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03322 Neighboring gene predicted gene, 37662 Neighboring gene predicted gene, 34797 Neighboring gene STARR-seq mESC enhancer starr_03323 Neighboring gene STARR-positive B cell enhancer ABC_E10074 Neighboring gene STARR-positive B cell enhancer ABC_E3348 Neighboring gene predicted gene, 53487 Neighboring gene small nucleolar RNA, H/ACA box 36B Neighboring gene predicted gene, 34882 Neighboring gene microRNA 664 Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene microRNA 194-1 Neighboring gene microRNA 215

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, et al. J Pineal Res, 2016 Jan. PMID 26514267
  2. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in establishment of protein localization to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein lipidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rab3 GTPase-activating protein non-catalytic subunit
Names
Rab3 GTPase-activating protein 150 kDa subunit
Rab3-GAP regulatory subunit
rab3-GAP p150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163754.2 → NP_001157226.1  rab3 GTPase-activating protein non-catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    AC129195, AC131084, AC158963
    Consensus CDS
    CCDS48478.1
    UniProtKB/Swiss-Prot
    Q6PEU0, Q80TQ6, Q8BMG7, Q8BX72
    UniProtKB/TrEMBL
    E9QKE4
    Related
    ENSMUSP00000066325.7, ENSMUST00000069652.8
    Conserved Domains (2) summary
    pfam14655
    Location:73 → 497
    RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
    pfam14656
    Location:779 → 1365
    RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

RNA

  1. NR_175935.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129195, AC131084, AC158963

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    184936287..185018953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497216.5 → XP_006497279.1  rab3 GTPase-activating protein non-catalytic subunit isoform X1

    UniProtKB/Swiss-Prot
    Q6PEU0, Q80TQ6, Q8BMG7, Q8BX72
    UniProtKB/TrEMBL
    A0A0A6YWM5
    Related
    ENSMUSP00000141608.2, ENSMUST00000194740.6
    Conserved Domains (2) summary
    pfam14655
    Location:73 → 497
    RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
    pfam14656
    Location:779 → 1345
    RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

RNA

  1. XR_004935356.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172649.1: Suppressed sequence

    Description
    NM_172649.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: RAB3GAP2 (GeneID:25782).
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMG7.2 GenPept UniProtKB/Swiss-Prot:Q8BMG7

Gene LinkOut

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