Rdh10 retinol dehydrogenase 10 (all-trans) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rdh10provided by MGI
Official Full Name: retinol dehydrogenase 10 (all-trans)provided by MGI
Primary source: MGI:MGI:1924238
See related: Ensembl:ENSMUSG00000025921 AllianceGenome:MGI:1924238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: m366Asp; D1Ertd762e; 3110069K09Rik; 4921506A21Rik
Summary: Enables NAD-retinol dehydrogenase activity. Acts upstream of or within several processes, including animal organ development; embryonic forelimb morphogenesis; and retinoic acid biosynthetic process. Located in membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 15.9), duodenum adult (RPKM 10.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 A3; 1 4.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (16176106..16202774)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (16105882..16132550)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function.
Title: Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function.
Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Title: Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
Embryos with deficient retinoid signaling were generated by stage-specific inactivation of retinol dehydrogenase 10 (Rdh10), a gene crucial for the production of RA during embryogenesis. The finding that cleft palate in retinoid deficiency results from a lack of fetal mouth movement might help elucidate cleft palate etiology and improve early diagnosis in human disorders involving defects of pharyngeal development
Title: RDH10 function is necessary for spontaneous fetal mouth movement that facilitates palate shelf elevation.
11-cis-retinol is oxidized selectively in cones to the 11-cis-retinal used for pigment regeneration; RDH10 is not the enzyme responsible for this oxidation.
Title: The role of retinol dehydrogenase 10 in the cone visual cycle.
RDH10 and Retinoic acid are required for salivary gland initiation.
Title: RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation.
Embryonic fibroblasts from Rdh10 heterozygote hypomorphs or with a total Rdh10 knockout exhibit decreased all-trans-retinoic acid biosynthesis and escalated adipogenesis.
Title: Modest Decreases in Endogenous All-trans-Retinoic Acid Produced by a Mouse Rdh10 Heterozygote Provoke Major Abnormalities in Adipogenesis and Lipid Metabolism.
Rdh10 null mutant mouse embryos exhibited dorsal pancreas agenesis and a hypoplastic ventral pancreas with retarded tubulogenesis and branching. Conditional disruption of Rdh10 from the endoderm caused increased mortality, reduced body weight, and lowered blood glucose levels after birth. Endodermal Rdh10 deficiency led to a smaller dorsal pancreas with a reduced density of early glucagon(+) and insulin(+) cells.
Title: Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.
Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study choanal atresia (CA)
Title: Rdh10 loss-of-function and perturbed retinoid signaling underlies the etiology of choanal atresia.
RDH10 acts in cooperation with other RDH isoforms to produce the 11-cis-retinal chromophore needed for vision.
Title: Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice.
Insulin inhibits retinoic acid biosynthesis through inhibition of FoxO1-induced Rdh10 gene expression.
Title: Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548373

D1Ertd762e (e-PCR), detects polymorphism
- UniSTS:167295

Rdh10 (e-PCR), detects polymorphism
- UniSTS:474758

AI875664 (e-PCR)
- UniSTS:165066

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info	PubMed
enables all-trans-retinol dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bud elongation involved in lung branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic forelimb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nose development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within primary lung bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: retinol dehydrogenase 10

NP_598593.1

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133832.3 → NP_598593.1 retinol dehydrogenase 10

See identical proteins and their annotated locations for NP_598593.1

Status: PROVISIONAL

Source sequence(s)

AC162442

Consensus CDS

CCDS14830.1

UniProtKB/Swiss-Prot

Q8CJ68, Q8VCH7

Related

ENSMUSP00000027053.8, ENSMUST00000027053.8

Conserved Domains (2) summary

cd05339
Location:38 → 307

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

pfam00106
Location:37 → 252

adh_short; short chain dehydrogenase