Trmt1l tRNA methyltransferase 1 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trmt1lprovided by MGI
Official Full Name: tRNA methyltransferase 1 likeprovided by MGI
Primary source: MGI:MGI:1916185
See related: Ensembl:ENSMUSG00000053286 AllianceGenome:MGI:1916185
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trm1l; C1orf25; Trm1-like; 1190005F20Rik
Summary: Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Acts upstream of or within adult locomotory behavior. Predicted to be active in nucleus. Is expressed in several structures, including axial skeleton; brown fat; nervous system; olfactory epithelium; and respiratory system. Orthologous to human TRMT1L (tRNA methyltransferase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 11.6), CNS E14 (RPKM 10.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G1; 1 64.12 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (151304293..151333934)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (151428542..151458183)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trm1-like deficient mice are viable and show no anatomical defects; behavioural tests, however, revealed significantly altered motor coordination and aberrant exploratory behaviour thus, Trm1 plays a role in modulating postnatal neuronal functions.
Title: The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

1190005F20Rik (e-PCR), detects polymorphism
- UniSTS:499062

1190005F20Rik (e-PCR), detects polymorphism
- UniSTS:499063

1190005F20Rik (e-PCR), detects polymorphism
- UniSTS:499064

1190005F20Rik (e-PCR), detects polymorphism
- UniSTS:499065

AW226554 (e-PCR)
- UniSTS:165108

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA (guanine(10)-N2)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA N2-guanine methylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TRMT1-like protein

NP_001344498.1

EC 2.1.1.-

NP_001344499.1

EC 2.1.1.-

NP_081152.2

EC 2.1.1.-

XP_030099757.1

EC 2.1.1.-

XP_036010624.1

EC 2.1.1.-

XP_036010625.1

EC 2.1.1.-

XP_036010628.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357569.1 → NP_001344498.1 TRMT1-like protein isoform 2

Status: VALIDATED

Source sequence(s)

AC165946

UniProtKB/Swiss-Prot

A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68

Conserved Domains (2) summary

cl17173
Location:225 → 666

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

cl22851
Location:157 → 202

PHD_SF; PHD finger superfamily
NM_001357570.1 → NP_001344499.1 TRMT1-like protein isoform 3

Status: VALIDATED

Source sequence(s)

AI853808, AK148524, BC064024

Conserved Domains (1) summary

cl17173
Location:16 → 419

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_026876.4 → NP_081152.2 TRMT1-like protein isoform 1

See identical proteins and their annotated locations for NP_081152.2

Status: VALIDATED

Source sequence(s)

AI853808, AK148524, BC110425

Consensus CDS

CCDS15361.1

UniProtKB/Swiss-Prot

A2RSY6, Q0VGB9, Q3UFG1, Q3UKB0, Q8C2S4, Q8CI50, Q8R203, Q9CT68

UniProtKB/TrEMBL

A0A0R4J0U8

Related

ENSMUSP00000068309.6, ENSMUST00000065625.12

Conserved Domains (2) summary

cl17173
Location:225 → 687

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

cl22851
Location:157 → 202

PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

151304293..151333934

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154732.1 → XP_036010625.1 TRMT1-like protein isoform X3

Conserved Domains (1) summary

cl17173
Location:225 → 425

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036154731.1 → XP_036010624.1 TRMT1-like protein isoform X1

Conserved Domains (1) summary

cl17173
Location:72 → 534

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_030243897.2 → XP_030099757.1 TRMT1-like protein isoform X2

Conserved Domains (1) summary

cl17173
Location:16 → 419

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
XM_036154735.1 → XP_036010628.1 TRMT1-like protein isoform X4

Conserved Domains (1) summary

cl17173
Location:16 → 398

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...