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Mfsd6 major facilitator superfamily domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 98682, updated on 5-Mar-2024

Summary

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Official Symbol
Mfsd6provided by MGI
Official Full Name
major facilitator superfamily domain containing 6provided by MGI
Primary source
MGI:MGI:1922925
See related
Ensembl:ENSMUSG00000041439 AllianceGenome:MGI:1922925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMR2; 2210010L05Rik; 9630025I22Rik
Summary
Enables MHC class I protein binding activity and MHC class I receptor activity. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in plasma membrane. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 15.1), cerebellum adult (RPKM 7.8) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.1; 1 26.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52695463..52766495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52656286..52727358, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00902 Neighboring gene STARR-seq mESC enhancer starr_00903 Neighboring gene predicted gene 5527 Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E3275 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma. Tashiro-Yamaji J, et al. Transplantation, 2013 Aug 15. PMID 23836286
  2. HLA-B62 as a possible ligand for the human homologue of mouse macrophage MHC receptor 2 (MMR2) on monocytes. Shimizu T, et al. Gene, 2010 Apr 1. PMID 20123006
  3. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption. Bagchi S, et al. Int J Neurosci, 2020 May. PMID 31906755
  4. Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice. Tashiro-Yamaji J, et al. Gene, 2006 Dec 15. PMID 17010536
  5. NOVA2 regulates neural circRNA biogenesis. Knupp D, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34157123, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
    Title: Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption.
  2. MMRs on monocytes/macrophages and TCRs on cytotoxic T lymphocytes in mice were essential for recognition and rejection of allografted skin and lymphoma, respectively.
    Title: Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma.
  3. isolation of a cDNA clone encoding a novel receptor (MMR2) on allograft (H-2D(d)K(d))-induced macrophages (AIM) recognizing another MHC class I molecule, H-2K(d), by the expression cloning method
    Title: Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class I protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables MHC class I receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
major facilitator superfamily domain-containing protein 6
Names
macrophage MHC class I receptor 2
macrophage MHC receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357464.2 → NP_001344393.1  major facilitator superfamily domain-containing protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139299, AC161876
    Conserved Domains (1) summary
    cd17335
    Location:71 → 625
    MFS_MFSD6; Major facilitator superfamily domain-containing protein 6

  2. NM_001403607.1 → NP_001390536.1  major facilitator superfamily domain-containing protein 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139299, AC161876

  3. NM_001403611.1 → NP_001390540.1  major facilitator superfamily domain-containing protein 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC139299, AC161876
    UniProtKB/TrEMBL
    D3Z183

  4. NM_133829.3 → NP_598590.2  major facilitator superfamily domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_598590.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139299, AC161876
    Consensus CDS
    CCDS14945.2
    UniProtKB/TrEMBL
    D3Z183
    Related
    ENSMUSP00000122881.2, ENSMUST00000156876.8
    Conserved Domains (2) summary
    PHA03381
    Location:666 → 779
    PHA03381; tegument protein VP22; Provisional
    cd17335
    Location:71 → 625
    MFS_MFSD6; Major facilitator superfamily domain-containing protein 6

  5. NM_178081.5 → NP_835182.1  major facilitator superfamily domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_835182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC139299, AC161876
    Consensus CDS
    CCDS14946.1
    UniProtKB/Swiss-Prot
    Q8C8K4, Q8CBH5, Q8VIG4
    Related
    ENSMUSP00000084991.4, ENSMUST00000087701.4
    Conserved Domains (4) summary
    cd06174
    Location:453 → 623
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:453 → 651
    MFS_1; Major Facilitator Superfamily
    pfam12832
    Location:68 → 143
    MFS_1_like; MFS_1 like family
    pfam16038
    Location:366 → 395
    TMIE; TMIE protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52695463..52766495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CBH5.1 GenPept UniProtKB/Swiss-Prot:Q8CBH5

Gene LinkOut

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