MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAGI2provided by HGNC
Official Full Name: membrane associated guanylate kinase, WW and PDZ domain containing 2provided by HGNC
Primary source: HGNC:HGNC:18957
See related: Ensembl:ENSG00000187391 MIM:606382; AllianceGenome:HGNC:18957
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AIP1; AIP-1; ARIP1; SSCAM; MAGI-2; NPHS15; ACVRIP1
Summary: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
Expression: Broad expression in brain (RPKM 4.1), thyroid (RPKM 1.2) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.11

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (78017055..79453667, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (79268893..80705470, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (77646372..79082983, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-beta-Smad3/nephrin pathway.
Title: MAGI2 ameliorates podocyte apoptosis of diabetic kidney disease through communication with TGF-β-Smad3/nephrin pathway.
The TLR4/NF-kappaB/MAGI-2 signaling pathway mediates postoperative delirium.
Title: The TLR4/NF-κB/MAGI-2 signaling pathway mediates postoperative delirium.
Comparative study of immunohistochemical expression of ERG and MAGI2 in prostatic carcinoma.
Title: Comparative study of immunohistochemical expression of ERG and MAGI2 in prostatic carcinoma.
HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.
Title: HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.
Polymorphism in the MAGI2 Gene Modifies the Effect of Amyloid beta on Neurodegeneration.
Title: Polymorphism in the MAGI2 Gene Modifies the Effect of Amyloid β on Neurodegeneration.
GLIDR promotes the progression of glioma by regulating the miR-4677-3p/MAGI2 axis.
Title: GLIDR promotes the progression of glioma by regulating the miR-4677-3p/MAGI2 axis.
Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.
Title: Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.
MAGI-2 downregulation: a potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer.
Title: MAGI-2 downregulation: a potential predictor of tumor progression and early recurrence in Han Chinese patients with prostate cancer.
MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2.
Title: MAGI2-AS3 inhibits breast cancer by downregulating DNA methylation of MAGI2.
Novel insights for lncRNA MAGI2-AS3 in solid tumors.
Title: Novel insights for lncRNA MAGI2-AS3 in solid tumors.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Nephrotic syndrome 15 MedGen: C4539896 OMIM: 617609 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study (GWAS) for bronchopulmonary dysplasia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:4585245 (e-PCR)
- UniSTS:37632

SHGC-60231 (e-PCR)
- UniSTS:22535

WI-22277 (e-PCR)
- UniSTS:53529

G32958 (e-PCR)
- UniSTS:117535

GDB:1317710 (e-PCR)
- UniSTS:551

AFM312xb5 (e-PCR)
- UniSTS:32808

SHGC-81349 (e-PCR)
- UniSTS:102709

GDB:1318152 (e-PCR)
- UniSTS:54581

SHGC-60232 (e-PCR)
- UniSTS:70455

SHGC-79837 (e-PCR)
- UniSTS:101431

SHGC-132385 (e-PCR)
- UniSTS:170809

RH120526 (e-PCR)
- UniSTS:133691

GDB:1317844 (e-PCR)
- UniSTS:18495

GDB:1317838 (e-PCR)
- UniSTS:20031

G17176 (e-PCR)
- UniSTS:2370

G17119 (e-PCR)
- UniSTS:41306

SHGC-79835 (e-PCR)
- UniSTS:101724

D7S2135E (e-PCR)
- UniSTS:151133

GDB:1318164 (e-PCR)
- UniSTS:37727

GDB:1317902 (e-PCR)
- UniSTS:58208

D7S2526 (e-PCR), detects polymorphism
- UniSTS:65129

GDB:1318491 (e-PCR)
- UniSTS:23407

D7S2421 (e-PCR)
- UniSTS:71799

GDB:1317594 (e-PCR)
- UniSTS:83068

CHLC.GATA8G02 (e-PCR)
- UniSTS:28284

D7S1446 (e-PCR)
- UniSTS:41853

D7S2517 (e-PCR), detects polymorphism
- UniSTS:25479

SHGC-82131 (e-PCR)
- UniSTS:103051

AFMb281wd5 (e-PCR)
- UniSTS:28300

D7S2815 (e-PCR)
- UniSTS:40082

WI-18076 (e-PCR)
- UniSTS:1171

D7S1859 (e-PCR)
- UniSTS:37787

D7S2421 (e-PCR)
- UniSTS:28829

RH118918 (e-PCR)
- UniSTS:138910

SHGC-31136 (e-PCR)
- UniSTS:20133

D7S1950 (e-PCR)
- UniSTS:24746

SHGC-85234 (e-PCR)
- UniSTS:104368

SHGC-53900 (e-PCR)
- UniSTS:37299

GDB:1317842 (e-PCR)
- UniSTS:5049

RH119987 (e-PCR)
- UniSTS:133311

GDB:1318088 (e-PCR)
- UniSTS:4801

SHGC-31005 (e-PCR)
- UniSTS:80072

A009X37 (e-PCR)
- UniSTS:80584

SHGC-84053 (e-PCR)
- UniSTS:104648

D7S669 (e-PCR), detects polymorphism
- UniSTS:19410

D7S2204 (e-PCR)
- UniSTS:65492

GDB:1317846 (e-PCR)
- UniSTS:8921

GDB:1317832 (e-PCR)
- UniSTS:12009

D7S669 (e-PCR), detects polymorphism
- UniSTS:3053

SHGC-82461 (e-PCR)
- UniSTS:104429

MAGI2 (e-PCR)
- UniSTS:503538

SHGC-83003 (e-PCR)
- UniSTS:101880

SGC30594 (e-PCR)
- UniSTS:29945

SHGC-80080 (e-PCR)
- UniSTS:102137

D7S1885 (e-PCR)
- UniSTS:41470

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables SMAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables beta-1 adrenergic receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1 adrenergic receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor complex adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables type II activin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type II activin receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in clathrin-dependent endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of activin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in nerve growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in axis elongation	NAS Non-traceable Author Statement more info	PubMed
involved_in podocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor outer segment	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in slit diaphragm	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

Names: activin receptor interacting protein 1; atrophin-1-interacting protein 1; atrophin-1-interacting protein A; membrane-associated guanylate kinase inverted 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011487.2 RefSeqGene

Range

4908..1441520

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001301128.2 → NP_001288057.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001288057.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AA448362, AA890379, AB014605, AC004808, AC004945, AC004990, AF038563, AK297353, Z19922

Consensus CDS

CCDS75623.1

UniProtKB/TrEMBL

B7Z4H4

Related

ENSP00000405766.1, ENST00000419488.5

Conserved Domains (6) summary

smart00072
Location:118 → 291

GuKc; Guanylate kinase homologues

smart00228
Location:761 → 847

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:305 → 335

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1132 → 1212

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:350 → 379

WW; WW domain

pfam16666
Location:682 → 756

MAGI_u5; Unstructured region on MAGI
NM_012301.4 → NP_036433.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_036433.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AA448362, AB014605, AC004808, AC004945, AC004990, AC007237, AF038563

Consensus CDS

CCDS5594.1

UniProtKB/Swiss-Prot

A4D1C1, A7E2C3, O60434, O60510, Q86UI7, Q86UL8, Q9NP44, Q9UDQ5, Q9UDU1

UniProtKB/TrEMBL

B7Z4H4

Related

ENSP00000346151.4, ENST00000354212.9

Conserved Domains (6) summary

smart00072
Location:118 → 291

GuKc; Guanylate kinase homologues

smart00228
Location:775 → 861

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:305 → 335

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1146 → 1226

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:350 → 379

WW; WW domain

pfam16666
Location:682 → 756

MAGI_u5; Unstructured region on MAGI

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

78017055..79453667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421093.1 → XP_047277049.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10
XM_017012845.3 → XP_016868334.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7

UniProtKB/TrEMBL

B7Z4H4
XM_017012846.3 → XP_016868335.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X9

UniProtKB/TrEMBL

B7Z4H4
XM_011516718.3 → XP_011515020.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6

UniProtKB/TrEMBL

B7Z4H4

Related

ENSP00000428389.1, ENST00000522391.3

Conserved Domains (6) summary

smart00072
Location:118 → 291

GuKc; Guanylate kinase homologues

smart00228
Location:775 → 861

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:305 → 335

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1146 → 1226

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:350 → 379

WW; WW domain

pfam16666
Location:682 → 756

MAGI_u5; Unstructured region on MAGI
XM_017012841.3 → XP_016868330.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2

UniProtKB/TrEMBL

B7Z4H4
XM_017012842.3 → XP_016868331.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3

UniProtKB/TrEMBL

B7Z4H4
XM_047421092.1 → XP_047277048.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8
XM_017012843.3 → XP_016868332.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4

UniProtKB/TrEMBL

B7Z4H4
XM_017012844.3 → XP_016868333.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5

UniProtKB/TrEMBL

B7Z4H4
XM_017012840.3 → XP_016868329.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1

UniProtKB/TrEMBL

B7Z4H4
XM_017012847.3 → XP_016868336.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11

UniProtKB/TrEMBL

A0A0D9SEY4

Conserved Domains (7) summary

smart00228
Location:655 → 741

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:142 → 172

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1026 → 1106

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:187 → 216

WW; WW domain

pfam16663
Location:35 → 96

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:562 → 636

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 128

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_011516720.4 → XP_011515022.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11

See identical proteins and their annotated locations for XP_011515022.1

UniProtKB/TrEMBL

A0A0D9SEY4

Related

ENSP00000486131.1, ENST00000626691.2

Conserved Domains (7) summary

smart00228
Location:655 → 741

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00201
Location:142 → 172

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd00992
Location:1026 → 1106

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00397
Location:187 → 216

WW; WW domain

pfam16663
Location:35 → 96

MAGI_u1; Unstructured region on MAGI

pfam16666
Location:562 → 636

MAGI_u5; Unstructured region on MAGI

cl17190
Location:1 → 128

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
XM_011516728.2 → XP_011515030.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X12

Conserved Domains (3) summary

smart00228
Location:384 → 470

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:755 → 835

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam16666
Location:291 → 365

MAGI_u5; Unstructured region on MAGI

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

79268893..80705470 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054359444.1 → XP_054215419.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X10
XM_054359441.1 → XP_054215416.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X7
XM_054359443.1 → XP_054215418.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X9
XM_054359440.1 → XP_054215415.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X6
XM_054359436.1 → XP_054215411.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X2
XM_054359437.1 → XP_054215412.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X3
XM_054359442.1 → XP_054215417.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X8
XM_054359438.1 → XP_054215413.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X4
XM_054359439.1 → XP_054215414.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X5
XM_054359435.1 → XP_054215410.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1
XM_054359446.1 → XP_054215421.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11
XM_054359445.1 → XP_054215420.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X11