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PPP1R26 protein phosphatase 1 regulatory subunit 26 [ Homo sapiens (human) ]

Gene ID: 9858, updated on 5-Mar-2024

Summary

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Official Symbol
PPP1R26provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 26provided by HGNC
Primary source
HGNC:HGNC:29089
See related
Ensembl:ENSG00000196422 MIM:614056; AllianceGenome:HGNC:29089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRBE3; KIAA0649
Summary
Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of phosphatase activity. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 4.1), kidney (RPKM 3.8) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
9q34.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (135479066..135488892)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (147707139..147716966)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (138371628..138380738)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene suppressor of cytokine signaling 5 pseudogene 2 Neighboring gene PPP1R26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138356815-138357468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20483 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138380833-138381544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382256-138382966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:138382967-138383677 Neighboring gene piercer of microtubule wall 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20487 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:138392753-138393377 Neighboring gene uncharacterized LOC101928525 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:138396029-138396183 Neighboring gene mitochondrial ribosomal protein S2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression. Zheng T, et al. Biochim Biophys Acta Mol Cell Res, 2018 Dec. PMID 30262434
  2. A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor. Wang Y, et al. J Biol Chem, 2015 Nov 20. PMID 26442585, Free PMC Article
  3. KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential. Yang L, et al. Biochem Biophys Res Commun, 2005 Sep 2. PMID 16053918
  4. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Ishikawa K, et al. DNA Res, 1998 Jun 30. PMID 9734811
  5. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Nakayama M, et al. Genome Res, 2002 Nov. PMID 12421765, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that up-regulation of NRBE3 is correlated with lymphatic metastasis in human breast cancer (BC) tissues. Ectopic expression of NRBE3 promotes migration and invasion in BC cells. Accordingly, its knockdown inhibits migration and invasion in BC cells and lung metastasis in vivo.
    Title: NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression.
  2. identified NRBE3 as a novel ubiquitin E3 ligase for RB that might play a role as a potential oncoprotein in human cancers
    Title: A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor.
  3. we showed that KIAA0649 mRNA is widely expressed in human multiple tissues and cell lines. We have also demonstrated that KIAA0649 has oncogenic characteristics: it enhances colony formation, allows anchorage-independent growth.
    Title: KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 26
Names
1A6/DRIM (down-regulated in metastasis) interacting protein
DRIM/UTP20 interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014811.5 → NP_055626.3  protein phosphatase 1 regulatory subunit 26

    See identical proteins and their annotated locations for NP_055626.3

    Status: VALIDATED

    Source sequence(s)
    AL161452
    Consensus CDS
    CCDS6988.1
    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Related
    ENSP00000349274.2, ENST00000356818.7
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    135479066..135488892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424216.1 → XP_047280172.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Related
    ENSP00000385826.3, ENST00000401470.3

  2. XM_017015358.2 → XP_016870847.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Related
    ENSP00000474807.1, ENST00000605286.5
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  3. XM_017015360.3 → XP_016870849.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  4. XM_047424222.1 → XP_047280178.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  5. XM_017015361.3 → XP_016870850.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  6. XM_047424220.1 → XP_047280176.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  7. XM_047424224.1 → XP_047280180.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  8. XM_024447721.2 → XP_024303489.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  9. XM_047424210.1 → XP_047280166.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  10. XM_017015362.3 → XP_016870851.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  11. XM_005263411.3 → XP_005263468.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    See identical proteins and their annotated locations for XP_005263468.1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Related
    ENSP00000473820.1, ENST00000604351.5
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  12. XM_047424217.1 → XP_047280173.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  13. XM_047424223.1 → XP_047280179.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  14. XM_047424218.1 → XP_047280174.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  15. XM_047424221.1 → XP_047280177.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  16. XM_047424212.1 → XP_047280168.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  17. XM_047424219.1 → XP_047280175.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  18. XM_017015357.2 → XP_016870846.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  19. XM_047424213.1 → XP_047280169.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  20. XM_017015356.3 → XP_016870845.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

  21. XM_047424214.1 → XP_047280170.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  22. XM_047424209.1 → XP_047280165.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  23. XM_047424215.1 → XP_047280171.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  24. XM_047424211.1 → XP_047280167.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  25. XM_017015355.3 → XP_016870844.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
    Conserved Domains (2) summary
    pfam15740
    Location:1 → 852
    PPP1R26_N; Protein phosphatase 1 regulatory subunit 26 N-terminus
    cl26386
    Location:762 → 1040
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    147707139..147716966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364353.1 → XP_054220328.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  2. XM_054364345.1 → XP_054220320.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  3. XM_054364363.1 → XP_054220338.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  4. XM_054364359.1 → XP_054220334.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  5. XM_054364365.1 → XP_054220340.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  6. XM_054364358.1 → XP_054220333.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  7. XM_054364354.1 → XP_054220329.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  8. XM_054364356.1 → XP_054220331.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  9. XM_054364347.1 → XP_054220322.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  10. XM_054364342.1 → XP_054220317.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  11. XM_054364364.1 → XP_054220339.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  12. XM_054364361.1 → XP_054220336.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  13. XM_054364360.1 → XP_054220335.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  14. XM_054364355.1 → XP_054220330.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  15. XM_054364357.1 → XP_054220332.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  16. XM_054364349.1 → XP_054220324.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  17. XM_054364362.1 → XP_054220337.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  18. XM_054364350.1 → XP_054220325.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  19. XM_054364344.1 → XP_054220319.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  20. XM_054364351.1 → XP_054220326.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  21. XM_054364346.1 → XP_054220321.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  22. XM_054364352.1 → XP_054220327.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  23. XM_054364348.1 → XP_054220323.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3

  24. XM_054364343.1 → XP_054220318.1  protein phosphatase 1 regulatory subunit 26 isoform X1

    UniProtKB/Swiss-Prot
    Q5T8A7, Q86WU0, Q8WVV0, Q9Y4D3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T8A7.1 GenPept UniProtKB/Swiss-Prot:Q5T8A7

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